(20 nodes) Negative regulation of viral genome replication network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	N4BP1	NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Belongs to the N4BP1 family. (930 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (2027 aa)
	HMGA2	High mobility group protein I-C. (109 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	AICDA	CMP/dCMP-type deaminase domain-containing protein. (198 aa)
	RSAD2	Viperin. (354 aa)
	MPHOSPH8	Uncharacterized protein. (858 aa)
	OASL	Uncharacterized protein. (484 aa)
	MORC2	MORC family CW-type zinc finger 2. (1025 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1386 aa)
	TASOR	Transcription activation suppressor. (1709 aa)
	BANF1	Barrier to autointegration factor 1. (90 aa)
	IFIH1	Uncharacterized protein. (1102 aa)
	RNASEL	Uncharacterized protein. (686 aa)
	IFNL3A	Interferon lambda-3; Cytokine which plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specif [...] (186 aa)
	KIAA1551	Uncharacterized protein. (1862 aa)
	LOC112530987	Uncharacterized protein. (342 aa)
	ILF3	Uncharacterized protein. (1076 aa)
	INPP5K	IPPc domain-containing protein. (465 aa)
	SPINK5	Ovoinhibitor; Seems to have at least five active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase. (517 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2AK2	IFIH1	ENSGALP00000017163	ENSGALP00000047949	Uncharacterized protein.	Uncharacterized protein.	0.953
EIF2AK2	ILF3	ENSGALP00000017163	ENSGALP00000066818	Uncharacterized protein.	Uncharacterized protein.	0.787
EIF2AK2	OASL	ENSGALP00000017163	ENSGALP00000028664	Uncharacterized protein.	Uncharacterized protein.	0.758
EIF2AK2	RNASEL	ENSGALP00000017163	ENSGALP00000050610	Uncharacterized protein.	Uncharacterized protein.	0.875
EIF2AK2	RSAD2	ENSGALP00000017163	ENSGALP00000026400	Uncharacterized protein.	Viperin.	0.959
EIF2AK2	ZNFX1	ENSGALP00000017163	ENSGALP00000007750	Uncharacterized protein.	Zinc finger NFX1-type containing 1.	0.672
IFIH1	EIF2AK2	ENSGALP00000047949	ENSGALP00000017163	Uncharacterized protein.	Uncharacterized protein.	0.953
IFIH1	OASL	ENSGALP00000047949	ENSGALP00000028664	Uncharacterized protein.	Uncharacterized protein.	0.728
IFIH1	RNASEL	ENSGALP00000047949	ENSGALP00000050610	Uncharacterized protein.	Uncharacterized protein.	0.780
IFIH1	RSAD2	ENSGALP00000047949	ENSGALP00000026400	Uncharacterized protein.	Viperin.	0.945
IFIH1	ZNFX1	ENSGALP00000047949	ENSGALP00000007750	Uncharacterized protein.	Zinc finger NFX1-type containing 1.	0.657
IFNL3A	OASL	ENSGALP00000052417	ENSGALP00000028664	Interferon lambda-3; Cytokine which plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specif [...]	Uncharacterized protein.	0.452
ILF3	EIF2AK2	ENSGALP00000066818	ENSGALP00000017163	Uncharacterized protein.	Uncharacterized protein.	0.787
MORC2	MPHOSPH8	ENSGALP00000037440	ENSGALP00000027637	MORC family CW-type zinc finger 2.	Uncharacterized protein.	0.570
MORC2	TASOR	ENSGALP00000037440	ENSGALP00000044647	MORC family CW-type zinc finger 2.	Transcription activation suppressor.	0.626
MPHOSPH8	MORC2	ENSGALP00000027637	ENSGALP00000037440	Uncharacterized protein.	MORC family CW-type zinc finger 2.	0.570
MPHOSPH8	SETDB1	ENSGALP00000027637	ENSGALP00000039776	Uncharacterized protein.	SET domain bifurcated histone lysine methyltransferase 1.	0.694
MPHOSPH8	TASOR	ENSGALP00000027637	ENSGALP00000044647	Uncharacterized protein.	Transcription activation suppressor.	0.938
OASL	EIF2AK2	ENSGALP00000028664	ENSGALP00000017163	Uncharacterized protein.	Uncharacterized protein.	0.758
OASL	IFIH1	ENSGALP00000028664	ENSGALP00000047949	Uncharacterized protein.	Uncharacterized protein.	0.728