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TFPI TFPI LAMTOR5 LAMTOR5 LCK LCK ADRA1A ADRA1A CDH1 CDH1 PLLP PLLP STOML2 STOML2 LCP2 LCP2 PTRF PTRF P2RX7 P2RX7 PPT1 PPT1 NPHS2 NPHS2 SLC6A4 SLC6A4 CARD11 CARD11 AQP1 AQP1 CTSD CTSD CBL CBL MYO1B MYO1B RTN4R RTN4R TRPC5 TRPC5 CLN6 CLN6 CAV3 CAV3 PIKFYVE PIKFYVE AKAP6 AKAP6 LRP8 LRP8 PLPP3 PLPP3 TGFBR2 TGFBR2 AKAP5 AKAP5 AMHR2 AMHR2 KIF18A KIF18A LYPD6 LYPD6 SYNJ2 SYNJ2 EZR EZR KDR KDR PACSIN2 PACSIN2 IL6ST IL6ST CDH2 CDH2 CBLB CBLB ARC ARC HTR2A HTR2A STOML3 STOML3 UNC5A UNC5A TRPC4 TRPC4 TSTD1 TSTD1 ADAM17 ADAM17 UNC5B UNC5B PRKAR1A PRKAR1A STOM STOM APP APP RIPK1 RIPK1 BVES BVES FAS FAS THY1 THY1 GHSR GHSR PRKCDBP PRKCDBP ARID3A ARID3A CAVIN4 CAVIN4 CD24 CD24 CAV1 CAV1 VDAC1 VDAC1 ADTRP ADTRP STIM1 STIM1 CTNNB1 CTNNB1 PLPP1 PLPP1 TPP1 TPP1 LYN LYN CDH15 CDH15 PARK7 PARK7 SMO SMO ADGRG1 ADGRG1 LDHB LDHB TNFRSF1A TNFRSF1A ADD2 ADD2 INPP5D INPP5D DAG1 DAG1 IKBKB IKBKB LOC112533511 LOC112533511 LRRK2 LRRK2 MLC1 MLC1 CD14 CD14 DPP4 DPP4 LRP6 LRP6 ARID3C ARID3C SMPD2 SMPD2 ABCG2 ABCG2 TGFBR1 TGFBR1 ADCY1 ADCY1 ADCY8 ADCY8 SULF1 SULF1 PTPRC PTPRC MAL2 MAL2 TNFRSF8 TNFRSF8 SLC1A2 SLC1A2 TNFRSF1B TNFRSF1B PAG1 PAG1 LAMTOR2 LAMTOR2 PSEN2 PSEN2 MILR1 MILR1 AGRN AGRN RET RET LAMTOR3 LAMTOR3 ENSGALP00000060823 ENSGALP00000060823 KCNE3 KCNE3 FLOT2 FLOT2 FYB2 FYB2 CAV2 CAV2 NEU3 NEU3 PLVAP PLVAP SCARB1 SCARB1 CD4 CD4 ATP2B4 ATP2B4 MALL MALL NEU2 NEU2 LDLR LDLR MYO1A MYO1A LAMTOR1 LAMTOR1 EMP2 EMP2 BAALC BAALC DLL1 DLL1 ORAI1 ORAI1 LIPE LIPE HCK HCK CD36 CD36 TLR15 TLR15 ENSGALP00000069448 ENSGALP00000069448 LOC107049937 LOC107049937 PSEN1 PSEN1 FYN FYN PECAM1 PECAM1 ASAH2 ASAH2 ADCYAP1R1 ADCYAP1R1 VDR VDR SLC9A1 SLC9A1 NFAM1 NFAM1 KCNQ1 KCNQ1 PODXL PODXL LOC112530976 LOC112530976 TEK TEK PLPP2 PLPP2 SKAP1 SKAP1 ENSGALP00000072609 ENSGALP00000072609 RGS19 RGS19 FLOT1 FLOT1 LOC101750972 LOC101750972
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TFPITissue factor pathway inhibitor. (311 aa)
LAMTOR5Uncharacterized protein. (91 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
ADRA1AAdrenoceptor alpha 1A. (467 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
PLLPMARVEL domain-containing protein. (178 aa)
STOML2Stomatin like 2. (382 aa)
LCP2SH2 domain-containing protein. (550 aa)
PTRFLeucine zipper protein. (361 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
PPT1Uncharacterized protein. (300 aa)
NPHS2NPHS2 stomatin family member, podocin. (384 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (670 aa)
CARD11Uncharacterized protein. (1170 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
CBLUncharacterized protein. (903 aa)
MYO1BMyosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1112 aa)
RTN4RReticulon 4 receptor. (483 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (969 aa)
CLN6Uncharacterized protein. (317 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
AKAP6A-kinase anchoring protein 6. (2342 aa)
LRP8Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa)
PLPP3acidPPc domain-containing protein. (313 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
AKAP5Uncharacterized protein. (596 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (969 aa)
LYPD6LY6/PLAUR domain containing 6. (186 aa)
SYNJ2Synaptojanin 2. (1491 aa)
EZREzrin. (585 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa)
IL6STGlycoprotein 130. (918 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
CBLBCbl proto-oncogene B. (1025 aa)
ARCActivity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis- dependent forms [...] (404 aa)
HTR2A5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa)
STOML3Stomatin like 3. (283 aa)
UNC5AUnc-5 netrin receptor A. (811 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
TSTD1Uncharacterized protein. (358 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
UNC5BUncharacterized protein. (945 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
STOMStomatin. (281 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
RIPK1Uncharacterized protein. (682 aa)
BVESBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Involved in epithelial movement during corneal sheet formation and regeneration. May play a role in VAMP3-mediated vesicular transport and recycling of receptor molecules. May play a role in the regulation of cell shape and movement by mod [...] (492 aa)
FASUncharacterized protein. (339 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa)
GHSRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
PRKCDBPCaveolae associated protein 2. (392 aa)
ARID3AAT-rich interaction domain 3A. (625 aa)
CAVIN4Caveolae associated protein 4. (357 aa)
CD24Uncharacterized protein. (87 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
VDAC1Uncharacterized protein. (307 aa)
ADTRPAndrogen dependent TFPI regulating protein. (233 aa)
STIM1SAM domain-containing protein. (742 aa)
CTNNB1Uncharacterized protein. (781 aa)
PLPP1Phospholipid phosphatase 1. (284 aa)
TPP1Tripeptidyl peptidase 1. (575 aa)
LYNTyrosine-protein kinase. (491 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
PARK7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
TNFRSF1AUncharacterized protein. (427 aa)
ADD2Adducin 2. (775 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1145 aa)
DAG1Peptidase S72 domain-containing protein. (896 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
LOC112533511Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (593 aa)
LRRK2Uncharacterized protein. (2557 aa)
MLC1Modulator of VRAC current 1. (379 aa)
CD14Uncharacterized protein. (465 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
ARID3CAT-rich interaction domain 3C. (472 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (410 aa)
ABCG2ATP-binding cassette sub-family G member 2. (701 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
SULF1Sulfatase 1. (862 aa)
PTPRCUncharacterized protein. (1237 aa)
MAL2MARVEL domain-containing protein. (178 aa)
TNFRSF8TNFR-Cys domain-containing protein. (467 aa)
SLC1A2Amino acid transporter. (554 aa)
TNFRSF1BUncharacterized protein. (462 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (403 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (312 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa)
MILR1Uncharacterized protein. (357 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
LAMTOR3Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (182 aa)
ENSGALP00000060823Ig-like domain-containing protein. (511 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (94 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
FYB2FYN binding protein 2. (676 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
NEU3Sialidase domain-containing protein. (636 aa)
PLVAPUncharacterized protein. (415 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
CD4Uncharacterized protein. (487 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa)
MALLUncharacterized protein. (162 aa)
NEU2Neuraminidase 2. (413 aa)
LDLRUncharacterized protein. (302 aa)
MYO1AUnconventional myosin-Ia; Could play an important role in morphogenesis and function of intestinal microvilli; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1257 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
EMP2Epithelial membrane protein 2. (167 aa)
BAALCBAALC binder of MAP3K1 and KLF4. (141 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
ORAI1Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (226 aa)
LIPEHSL_N domain-containing protein. (491 aa)
HCKTyrosine-protein kinase. (514 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
TLR15TIR domain-containing protein. (924 aa)
ENSGALP00000069448Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (409 aa)
LOC107049937Uncharacterized protein. (608 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
FYNTyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (712 aa)
ASAH2Neutral ceramidase. (759 aa)
ADCYAP1R1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (499 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. (608 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
NFAM1Uncharacterized protein. (323 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
LOC112530976FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (77 aa)
TEKTEK receptor tyrosine kinase. (1128 aa)
PLPP2Phospholipid phosphatase 2. (542 aa)
SKAP1Src kinase associated phosphoprotein 1. (355 aa)
ENSGALP00000072609Uncharacterized protein. (215 aa)
RGS19Uncharacterized protein. (399 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (876 aa)
LOC101750972Peptidase S72 domain-containing protein. (1177 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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