STRINGSTRING
PTTG2 PTTG2 EME2 EME2 TSHB TSHB ERCC4 ERCC4 FANCD2 FANCD2 TERB1 TERB1 TEX11 TEX11 HFM1-2 HFM1-2 PLK1 PLK1 EME1 EME1 BUB1 BUB1 MLH3 MLH3 MSH4 MSH4 CENPC CENPC DMC1 DMC1 RMI1 RMI1 TTK TTK ATM ATM SIRT7 SIRT7 SMC4 SMC4 MEIOB MEIOB SGO1 SGO1 C8H1ORF146 C8H1ORF146 NUF2 NUF2 CENPS CENPS LOC769510 LOC769510 NAIF1 NAIF1 CCNE2 CCNE2 MEI4 MEI4 MLH1 MLH1 RNF212 RNF212 LOC101748521 LOC101748521 MND1 MND1 RAD51C RAD51C SLX4 SLX4 SPO11 SPO11 TOP2A TOP2A NDC1 NDC1 SHOC1 SHOC1 ESPL1 ESPL1 BUB1B BUB1B HORMAD1 HORMAD1 AGO4 AGO4 MEIKIN MEIKIN PSMC3IP PSMC3IP ENSGALP00000064257 ENSGALP00000064257 SYCE3 SYCE3 TRIP13 TRIP13 ACTR2 ACTR2 ENSGALP00000065332 ENSGALP00000065332 SUN1 SUN1 M1AP M1AP C14orf39 C14orf39 SGO2 SGO2 TOP2B TOP2B ENSGALP00000068316 ENSGALP00000068316 SPATA22 SPATA22 ENSGALP00000070777 ENSGALP00000070777 NCAPH2 NCAPH2 CENPX CENPX HFM1 HFM1 LOC112530325 LOC112530325 MEIOC MEIOC TEX12 TEX12 NCAPH NCAPH ANKLE1 ANKLE1 HORMAD2 HORMAD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTTG2Uncharacterized protein. (193 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (273 aa)
TSHBThyrotropin subunit beta. (210 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
FANCD2Uncharacterized protein. (1510 aa)
TERB1Telomere repeat binding bouquet formation protein 1. (679 aa)
TEX11Uncharacterized protein. (311 aa)
HFM1-2Helicase ATP-binding domain-containing protein. (227 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
EME1Essential meiotic structure-specific endonuclease 1. (568 aa)
BUB1Uncharacterized protein. (1087 aa)
MLH3MutL homolog 3. (1446 aa)
MSH4DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (878 aa)
CENPCUncharacterized protein. (872 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (328 aa)
RMI1RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). (627 aa)
TTKTTK protein kinase. (880 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
SIRT7Deacetylase sirtuin-type domain-containing protein. (399 aa)
SMC4Structural maintenance of chromosomes protein. (1300 aa)
MEIOBMeiosis specific with OB-fold. (344 aa)
SGO1Shugoshin_C domain-containing protein. (607 aa)
C8H1ORF146Uncharacterized protein. (177 aa)
NUF2Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity); Belongs to the NUF2 family. (469 aa)
CENPSCentromere protein S; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP- dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked re [...] (139 aa)
LOC769510Uncharacterized protein. (889 aa)
NAIF1Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family. (328 aa)
CCNE2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
MEI4Meiotic double-stranded break formation protein 4. (400 aa)
MLH1DNA mismatch repair protein MLH1. (757 aa)
RNF212Ring finger protein 212. (304 aa)
LOC101748521DNA_MISMATCH_REPAIR_2 domain-containing protein. (809 aa)
MND1Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (225 aa)
RAD51CRAD51 paralog C. (360 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1740 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (382 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm. (1553 aa)
NDC1NDC1 transmembrane nucleoporin. (779 aa)
SHOC1Shortage in chiasmata 1. (1118 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2222 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1086 aa)
HORMAD1HORMA domain containing 1. (287 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (861 aa)
MEIKINUncharacterized protein. (405 aa)
PSMC3IPPSMC3 interacting protein. (251 aa)
ENSGALP00000064257Uncharacterized protein. (257 aa)
SYCE3Uncharacterized protein. (92 aa)
TRIP13Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (432 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...] (400 aa)
ENSGALP00000065332Uncharacterized protein. (277 aa)
SUN1Sad1 and UNC84 domain containing 1. (906 aa)
M1APMeiosis 1 associated protein. (536 aa)
C14orf39Chromosome 14 open reading frame 39. (589 aa)
SGO2Shugoshin_C domain-containing protein. (958 aa)
TOP2BDNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks; Belongs to the type II topoisomerase family. (1628 aa)
ENSGALP00000068316Shugoshin_C domain-containing protein. (1007 aa)
SPATA22Spermatogenesis associated 22. (363 aa)
ENSGALP00000070777Uncharacterized protein. (191 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (727 aa)
CENPXCentromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] (115 aa)
HFM1SEC63 domain-containing protein. (712 aa)
LOC112530325Uncharacterized protein. (58 aa)
MEIOCMeiosis specific with coiled-coil domain. (911 aa)
TEX12Testis expressed 12. (145 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (729 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (609 aa)
HORMAD2HORMA domain containing 2. (365 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.