STRINGSTRING
RAB2B RAB2B OCRL OCRL CDC42EP4 CDC42EP4 AMBRA1 AMBRA1 OVAL OVAL RAB10 RAB10 APPL2 APPL2 VAMP3 VAMP3 RAB7B RAB7B RAB31 RAB31 STX8 STX8 UVRAG UVRAG LAMP1 LAMP1 TMEM55A TMEM55A UNC93B1 UNC93B1 RAB23 RAB23 ENSGALP00000073042 ENSGALP00000073042 PIK3C3 PIK3C3 RAB11FIP1 RAB11FIP1 SLC11A2 SLC11A2 TLR15 TLR15 ANXA11 ANXA11 STXBP4 STXBP4 INPP5B INPP5B CDC42 CDC42 STXBP3 STXBP3 RAB7A RAB7A K4LB56_CHICK K4LB56_CHICK SYT11 SYT11 SYT7 SYT7 NOD1 NOD1 RAB9A RAB9A TRIM14 TRIM14 SYK SYK PLA2G5 PLA2G5 RAB32 RAB32 ATG14 ATG14 SLC11A1 SLC11A1 PIKFYVE PIKFYVE RAB11A RAB11A RAB22A RAB22A APPL1 APPL1 RAB9B RAB9B STX10 STX10 MTOR MTOR RILP RILP VPS26B VPS26B RAB14 RAB14 RAB11B RAB11B RAB38 RAB38 VAMP7 VAMP7 RAB39A RAB39A RAB20 RAB20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB2BUncharacterized protein. (428 aa)
OCRLRho-GAP domain-containing protein. (1013 aa)
CDC42EP4CDC42 effector protein 4. (302 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (273 aa)
UVRAGC2 domain-containing protein. (707 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
TMEM55APhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (571 aa)
RAB23Uncharacterized protein. (237 aa)
ENSGALP00000073042Rho-GAP domain-containing protein. (180 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
RAB11FIP1RAB11 family interacting protein 1. (1259 aa)
SLC11A2Uncharacterized protein. (1307 aa)
TLR15TIR domain-containing protein. (924 aa)
ANXA11Annexin. (496 aa)
STXBP4Syntaxin binding protein 4. (736 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (942 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
K4LB56_CHICKCD150. (333 aa)
SYT11Synaptotagmin 11. (432 aa)
SYT7Synaptotagmin 7. (403 aa)
NOD1Uncharacterized protein. (951 aa)
RAB9AUncharacterized protein. (201 aa)
TRIM14Uncharacterized protein. (433 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
PLA2G5Phospholipase A(2). (158 aa)
RAB32Uncharacterized protein. (218 aa)
ATG14Autophagy related 14. (492 aa)
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (555 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). (216 aa)
RAB22AUncharacterized protein. (194 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (806 aa)
RAB9BRAB9B, member RAS oncogene family. (261 aa)
STX10Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
RILPRab interacting lysosomal protein. (400 aa)
VPS26BVPS26, retromer complex component B. (336 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
RAB11BUncharacterized protein. (218 aa)
RAB38RAB38, member RAS oncogene family. (212 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa)
RAB39ARAB39A, member RAS oncogene family. (216 aa)
RAB20RAB20, member RAS oncogene family. (163 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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