STRINGSTRING
MYB MYB LEF1 LEF1 RHOH RHOH RIPK3 RIPK3 IL15 IL15 GATA3 GATA3 TOX TOX CD83 CD83 CD74 CD74 RASGRP1 RASGRP1 PCID2 PCID2 SASH3 SASH3 HLX HLX TESPA1 TESPA1 PCASP2 PCASP2 PTPRC PTPRC IL2RG IL2RG IL4R IL4R PCASP3 PCASP3 IL7 IL7 INPP5D INPP5D ZBTB32 ZBTB32 C6H10orf54 C6H10orf54 RIPK2 RIPK2 MALT1 MALT1 GAS6 GAS6 AMBRA1 AMBRA1 ZBTB1 ZBTB1 LOC101751887 LOC101751887 ANXA1 ANXA1 SYK SYK IL7R IL7R TGFBR2 TGFBR2 IHH IHH PPP2R3C PPP2R3C SOCS5 SOCS5 DUSP10 DUSP10 PCK1 PCK1 SOCS1 SOCS1 XBP1 XBP1 CBFB CBFB ZAP70 ZAP70 IL10 IL10 SOX13 SOX13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYBTranscriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
LEF1HMG box domain-containing protein. (412 aa)
RHOHRas homolog family member H. (191 aa)
RIPK3Uncharacterized protein. (424 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
TOXThymocyte selection associated high mobility group box. (525 aa)
CD83CD83 molecule. (215 aa)
CD74Invariant chain isoform p41. (286 aa)
RASGRP1RAS guanyl releasing protein 1. (480 aa)
PCID2PCI domain-containing protein. (399 aa)
SASH3Uncharacterized protein. (382 aa)
HLXH2.0 like homeobox. (431 aa)
TESPA1KRAP_IP3R_bind domain-containing protein. (600 aa)
PCASP2Uncharacterized protein. (741 aa)
PTPRCUncharacterized protein. (1237 aa)
IL2RGFibronectin type-III domain-containing protein. (384 aa)
IL4RFibronectin type-III domain-containing protein. (996 aa)
PCASP3Uncharacterized protein. (632 aa)
IL7Interleukin-7. (146 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1145 aa)
ZBTB32Uncharacterized protein. (665 aa)
C6H10orf54Ig-like domain-containing protein. (310 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
MALT1MALT1 paracaspase. (816 aa)
GAS6Growth arrest specific 6. (667 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
ZBTB1Zinc finger and BTB domain containing 1. (711 aa)
LOC101751887ANK_REP_REGION domain-containing protein. (178 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
IL7RInterleukin-7 receptor alpha chain. (460 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (461 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
DUSP10Uncharacterized protein. (478 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
XBP1BZIP domain-containing protein. (372 aa)
CBFBUncharacterized protein. (187 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
SOX13SRY-box transcription factor 13. (666 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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