STRINGSTRING
IL17A IL17A IL12B IL12B MED1 MED1 PITHD1 PITHD1 FADD FADD TESC TESC CASP8 CASP8 CREB1 CREB1 JAG1 JAG1 HMGB2 HMGB2 ABCB10 ABCB10 RCOR1 RCOR1 ANKRD54 ANKRD54 ROR2 ROR2 RAB7B RAB7B RIPK1 RIPK1 FAM210B FAM210B TNFSF11 TNFSF11 FOS FOS IL34 IL34 ENSGALP00000044025 ENSGALP00000044025 INHBA INHBA CSF3 CSF3 POU4F1 POU4F1 BRD1 BRD1 ACVR1B ACVR1B INPP5D INPP5D MTURN MTURN TMEM64 TMEM64 TGFB1 TGFB1 KLF10 KLF10 CASP10 CASP10 CD74 CD74 HOXA5 HOXA5 CSF1 CSF1 CASP18 CASP18 CD4 CD4 ENSGALP00000066095 ENSGALP00000066095 NEDD9 NEDD9 SMAP1 SMAP1 DCSTAMP DCSTAMP TRAF6 TRAF6 HAX1 HAX1 RB1 RB1 LOC112530285 LOC112530285 CTNNBIP1 CTNNBIP1 FAXDC2 FAXDC2 LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17AUncharacterized protein. (169 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
PITHD1PITH domain containing 1. (206 aa)
FADDFas associated via death domain. (195 aa)
TESCCalcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity). (214 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CREB1cAMP response element-binding protein. (327 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
HMGB2High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antige [...] (207 aa)
ABCB10ATP binding cassette subfamily B member 10. (523 aa)
RCOR1REST corepressor 1. (449 aa)
ANKRD54Ankyrin repeat domain 54. (168 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
RIPK1Uncharacterized protein. (682 aa)
FAM210BDUF1279 domain-containing protein. (186 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
IL34Interleukin 34. (178 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may [...] (424 aa)
CSF3Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. (201 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
BRD1Uncharacterized protein. (1243 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1145 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
TMEM64Transmembrane protein 64. (573 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (392 aa)
KLF10Kruppel like factor 10. (436 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (455 aa)
CD74Invariant chain isoform p41. (286 aa)
HOXA5Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (318 aa)
CSF1Uncharacterized protein. (493 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
CD4Uncharacterized protein. (487 aa)
ENSGALP00000066095Uncharacterized protein. (282 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
SMAP1Small ArfGAP 1. (473 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (472 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
HAX1HCLS1 associated protein X-1. (315 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
LOC112530285SAP domain-containing protein. (172 aa)
CTNNBIP1ICAT domain-containing protein. (81 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (335 aa)
LEF1HMG box domain-containing protein. (412 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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