STRINGSTRING
DLX1 DLX1 DISP3 DISP3 SOX8 SOX8 EIF4ENIF1 EIF4ENIF1 JAG1 JAG1 EIF2AK4 EIF2AK4 MIB1 MIB1 APP APP PHOX2B PHOX2B SOX9 SOX9 HES1 HES1 CNTF CNTF ISL1 ISL1 WNT2 WNT2 ENSGALP00000044025 ENSGALP00000044025 WNT2B WNT2B SOX2 SOX2 IRX3 IRX3 OLIG2 OLIG2 DLX2 DLX2 FOXG1 FOXG1 ZHX2 ZHX2 SIX3 SIX3 HES4 HES4 ENSGALP00000060823 ENSGALP00000060823 DIXDC1 DIXDC1 NEPRO NEPRO REST REST DLL1 DLL1 FST FST TLX2 TLX2 TP73 TP73 MED1 MED1 TLX3 TLX3 LSM1 LSM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX1Homeodomain transcription factor DLX1. (255 aa)
DISP3Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. (1338 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (990 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1656 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1167 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
PHOX2BPaired like homeobox 2B. (292 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
HES1Transcription factor HES-1. (257 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
WNT2BProtein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
IRX3Iroquois homeobox 3. (445 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
DLX2Distal-less homeobox 2. (253 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
ZHX2Zinc fingers and homeoboxes 2. (830 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
HES4Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). (290 aa)
ENSGALP00000060823Ig-like domain-containing protein. (511 aa)
DIXDC1DIX domain containing 1. (689 aa)
NEPRONucleolus and neural progenitor protein. (547 aa)
RESTUncharacterized protein. (339 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
FSTFollistatin; Binds directly to activin and functions as an activin antagonist. Inhibits activin A signaling in the iris and regulates somatostatin phenotype in ciliary ganglion neurons. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (320 aa)
TLX2Homeobox domain-containing protein. (634 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
TLX3T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (133 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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