STRINGSTRING
ACTL6B ACTL6B INO80D INO80D MBTD1 MBTD1 FAM178B FAM178B PIAS4 PIAS4 SHLD3 SHLD3 RNF8 RNF8 EYA4 EYA4 TIGAR TIGAR YEATS4 YEATS4 SHLD2 SHLD2 ACTL6A ACTL6A DDX11 DDX11 NPAS2 NPAS2 DMAP1 DMAP1 TMEM161A TMEM161A SHLD1 SHLD1 ACTR2 ACTR2 ACTR8 ACTR8 SIRT6 SIRT6 MCRS1 MCRS1 UIMC1 UIMC1 MGMT MGMT BRD8 BRD8 CEBPG CEBPG ARID2 ARID2 MRNIP MRNIP RUVBL2 RUVBL2 INO80E INO80E ENSGALP00000074157 ENSGALP00000074157 ERCC8 ERCC8 RNF168 RNF168 PARP9 PARP9 HDGFRP2 HDGFRP2 INO80 INO80 TIMELESS TIMELESS SETMAR SETMAR FAM168A FAM168A PNKP PNKP KMT5C KMT5C SPIRE2 SPIRE2 EYA3 EYA3 VPS72 VPS72 MFSD11 MFSD11 UCHL5 UCHL5 SIRT1 SIRT1 ENSGALP00000070978 ENSGALP00000070978 SLF1 SLF1 NFRKB NFRKB SPIDR SPIDR BRCA1 BRCA1 TRRAP TRRAP BCL7A BCL7A PARP3 PARP3 BRCC3 BRCC3 MRGBP MRGBP CCDC117 CCDC117 RUVBL1 RUVBL1 ERCC6 ERCC6 EPC1 EPC1 MMS19 MMS19 PARP1 PARP1 RIF1 RIF1 SPIRE1L SPIRE1L WDR48 WDR48 RPS3 RPS3 RAD51AP1 RAD51AP1 FANCB FANCB RBBP8 RBBP8 SMCHD1 SMCHD1 KMT5B KMT5B SPIRE1 SPIRE1 FOXM1 FOXM1 FH FH EPC2 EPC2 DTX3L DTX3L FAM175A FAM175A HELQ HELQ BRE BRE SLF2 SLF2 EYA1 EYA1 BABAM1 BABAM1 POGZ POGZ EYA2 EYA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
INO80DINO80 complex subunit D. (1030 aa)
MBTD1Mbt domain containing 1. (685 aa)
FAM178BUncharacterized protein. (653 aa)
PIAS4Protein inhibitor of activated STAT 4. (493 aa)
SHLD3Shieldin complex subunit 3. (249 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa)
EYA4Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...] (645 aa)
TIGARTIGAR. (280 aa)
YEATS4GAS41. (227 aa)
SHLD2Shieldin complex subunit 2. (895 aa)
ACTL6AActin like 6A; Belongs to the actin family. (429 aa)
DDX11DEAD/H-box helicase 11. (908 aa)
NPAS2Neuronal PAS domain-containing protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, [...] (849 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (488 aa)
TMEM161ATransmembrane protein 161A. (677 aa)
SHLD1Shieldin complex subunit 1. (240 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...] (400 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (622 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
MCRS1Microspherule protein 1. (513 aa)
UIMC1Ubiquitin interaction motif containing 1. (820 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (260 aa)
BRD8Bromo domain-containing protein. (969 aa)
CEBPGLeucine zipper transcription factor. (150 aa)
ARID2AT-rich interaction domain 2. (1886 aa)
MRNIPUncharacterized protein. (356 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (490 aa)
INO80EUncharacterized protein. (350 aa)
ENSGALP00000074157Uncharacterized protein. (199 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (775 aa)
HDGFRP2PWWP domain-containing protein. (641 aa)
INO80Uncharacterized protein. (1565 aa)
TIMELESSTimeless circadian regulator. (1264 aa)
SETMARUncharacterized protein. (297 aa)
FAM168AFamily with sequence similarity 168 member A. (235 aa)
PNKPUncharacterized protein. (206 aa)
KMT5CLysine methyltransferase 5C. (449 aa)
SPIRE2Spire type actin nucleation factor 2. (710 aa)
EYA3Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] (574 aa)
VPS72Vacuolar protein sorting 72 homolog. (365 aa)
MFSD11Major facilitator superfamily domain containing 11. (448 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (331 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
ENSGALP00000070978XRCC1_N domain-containing protein. (182 aa)
SLF1SMC5-SMC6 complex localization factor 1. (981 aa)
NFRKBNFRKB_winged domain-containing protein. (1308 aa)
SPIDRScaffold protein involved in DNA repair. (937 aa)
BRCA1Uncharacterized protein. (1749 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3836 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (91 aa)
PARP3Poly [ADP-ribose] polymerase. (526 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (261 aa)
MRGBPMRG domain binding protein. (233 aa)
CCDC117Coiled-coil domain containing 117. (321 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
EPC1Enhancer of polycomb homolog. (814 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1067 aa)
PARP1Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
RIF1Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity). (2168 aa)
SPIRE1LKIND domain-containing protein. (634 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
RAD51AP1Uncharacterized protein. (255 aa)
FANCBUncharacterized protein. (965 aa)
RBBP8RB binding protein 8, endonuclease. (912 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2031 aa)
KMT5BLysine methyltransferase 5B. (857 aa)
SPIRE1Spire type actin nucleation factor 1. (841 aa)
FOXM1Fork-head domain-containing protein. (795 aa)
FHUncharacterized protein. (507 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (737 aa)
FAM175ABRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. (405 aa)
HELQHelicase, POLQ like. (1048 aa)
BREBRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1189 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
BABAM1Uncharacterized protein. (460 aa)
POGZPogo transposable element derived with ZNF domain. (1322 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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