STRINGSTRING
PLEKHM1 PLEKHM1 DCSTAMP DCSTAMP ITGB3 ITGB3 SPP1 SPP1 MC4R MC4R SYK SYK TNFSF11 TNFSF11 DEF8 DEF8 TMEM64 TMEM64 TNFRSF11A TNFRSF11A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLEKHM1Uncharacterized protein. (1140 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (472 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
DEF8Differentially expressed in FDCP 8 homolog. (494 aa)
TMEM64Transmembrane protein 64. (573 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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