STRINGSTRING
INO80 INO80 YTHDC2 YTHDC2 CDC27 CDC27 IL10 IL10 MED1 MED1 GPSM2 GPSM2 LSM10 LSM10 KIF14 KIF14 CDC73 CDC73 POLDIP2 POLDIP2 HSF4 HSF4 ATAD5 ATAD5 CCND3 CCND3 FBXO42 FBXO42 ANAPC7 ANAPC7 MAD1L1 MAD1L1 SLC6A4 SLC6A4 CENPV CENPV CUL3 CUL3 CDC14A CDC14A KLHL18 KLHL18 PKD1 PKD1 CDC7 CDC7 NSFL1C NSFL1C NCAPG2 NCAPG2 CCND1 CCND1 CDC23 CDC23 DRD2 DRD2 ATRX ATRX SLF2 SLF2 KMT2E KMT2E PSMD10 PSMD10 CCNYL1 CCNYL1 TTL TTL DDR1 DDR1 GIPC2 GIPC2 DBF4 DBF4 ECT2 ECT2 ASNS ASNS PLK4 PLK4 SPAST SPAST LGMN LGMN EPGN EPGN EREG EREG CCNK CCNK DAZL DAZL LOC429032 LOC429032 MNAT1 MNAT1 PDGFB PDGFB CCNT2 CCNT2 EDN1 EDN1 RHNO1 RHNO1 CDT1 CDT1 CITED2 CITED2 ZPR1 ZPR1 NDC80 NDC80 MSX1 MSX1 DRD3 DRD3 SMC5 SMC5 CPSF3 CPSF3 RRM2 RRM2 GEN1 GEN1 PBK PBK CDC16 CDC16 TFDP1 TFDP1 CUL4A CUL4A RGCC RGCC BRCA2 BRCA2 CCND2 CCND2 RAD51AP1 RAD51AP1 RRM1 RRM1 SPDYA SPDYA ADAM17 ADAM17 TGFB2 TGFB2 NCAPH NCAPH ANXA1 ANXA1 SMC4 SMC4 FGF8 FGF8 C26H6orf89 C26H6orf89 APP APP DYNC1H1 DYNC1H1 STRA8 STRA8 ANAPC5 ANAPC5 TGFA TGFA LOC769510 LOC769510 BTC BTC CRNN CRNN MAD2L1BP MAD2L1BP UBE2C UBE2C CXCR5 CXCR5 ENSGALP00000044025 ENSGALP00000044025 SIRT2 SIRT2 SMPD3 SMPD3 USP19 USP19 TBX3 TBX3 LFNG LFNG LSM11 LSM11 RCC2 RCC2 PAF1 PAF1 UBXN2B UBXN2B FEN1 FEN1 CDK5R1 CDK5R1 CCNY CCNY RAD51C RAD51C E2F7 E2F7 PKD2 PKD2 NUMA1 NUMA1 CUL4B CUL4B CEP295 CEP295 CCPG1 CCPG1 CHEK2 CHEK2 DBF4B DBF4B ENSGALP00000050097 ENSGALP00000050097 IL1B IL1B DDR2 DDR2 KIF23 KIF23 ENSGALP00000050982 ENSGALP00000050982 NCAPG NCAPG CKS2 CKS2 LOC112533511 LOC112533511 DUSP3 DUSP3 RRM2B RRM2B LRP6 LRP6 NSMCE2 NSMCE2 TPR TPR FOXG1 FOXG1 E2F8 E2F8 MAPK15 MAPK15 RACGAP1 RACGAP1 RASAL3 RASAL3 HSF3 HSF3 ANKRD17 ANKRD17 CDC14B CDC14B HSF1 HSF1 CDC25A CDC25A TBX2 TBX2 CCDC57 CCDC57 GIPC3 GIPC3 FAM83D FAM83D XRCC3 XRCC3 MAD2L1 MAD2L1 PLRG1 PLRG1 THOC1 THOC1 HSP90AA1 HSP90AA1 PCID2 PCID2 THOC5 THOC5 CKS1B CKS1B STIL STIL ROCK2 ROCK2 MAP10 MAP10 RANBP1 RANBP1 CDC42 CDC42 ENSGALP00000066664 ENSGALP00000066664 MAP3K20 MAP3K20 MEPCE MEPCE STXBP4 STXBP4 CDC6 CDC6 CCNT1 CCNT1 CEP120 CEP120 CIT CIT CSPP1 CSPP1 CDC25B CDC25B RAD51B RAD51B DDX11 DDX11 SVIL SVIL FAM178B FAM178B FAM83D-2 FAM83D-2 SLF1 SLF1 PPP1R10 PPP1R10 MECP2 MECP2 BCL2L11 BCL2L11 NCAPH2 NCAPH2 RB1 RB1 ENSGALP00000071775 ENSGALP00000071775 SPAG5 SPAG5 RPTOR RPTOR GIPC1 GIPC1 MBLAC1 MBLAC1 MAPK15-2 MAPK15-2 MEIOC MEIOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INO80Uncharacterized protein. (1565 aa)
YTHDC2YTH domain containing 2. (1446 aa)
CDC27Uncharacterized protein. (833 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
GPSM2G protein signaling modulator 2. (663 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
CDC73Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (531 aa)
POLDIP2ApaG domain-containing protein. (373 aa)
HSF4HSF_DOMAIN domain-containing protein. (510 aa)
ATAD5AAA domain-containing protein. (1816 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
FBXO42F-box protein 42. (764 aa)
ANAPC7Anaphase promoting complex subunit 7. (565 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (717 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (670 aa)
CENPVGFA domain-containing protein. (207 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
CDC14AUncharacterized protein. (603 aa)
KLHL18BTB domain-containing protein. (581 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4382 aa)
CDC7Cell division cycle 7. (564 aa)
NSFL1CNSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (379 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1144 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
CDC23Cell division cycle 23. (595 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
ATRXATRX chromatin remodeler. (2420 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1189 aa)
KMT2ELysine methyltransferase 2E. (1814 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (365 aa)
TTLUncharacterized protein. (378 aa)
DDR1Uncharacterized protein. (873 aa)
GIPC2GIPC PDZ domain containing family member 2. (318 aa)
DBF4DBF4 zinc finger. (709 aa)
ECT2Epithelial cell transforming 2. (914 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
PLK4POLO box domain-containing protein. (566 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (613 aa)
LGMNLegumain. (431 aa)
EPGNEpigen; Promotes the growth of epithelial cells. (151 aa)
EREGEGF-like domain-containing protein. (153 aa)
CCNKUncharacterized protein; Belongs to the cyclin family. (587 aa)
DAZLDeleted in azoospermia-like; RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity); Belongs to the RRM DAZ family. (289 aa)
LOC429032Rho-GAP domain-containing protein. (568 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
CCNT2Uncharacterized protein. (501 aa)
EDN1Endothelin 1. (194 aa)
RHNO1Uncharacterized protein. (264 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
CITED2Cited2/melanocyte specific gene-related gene 1 MRG1. (236 aa)
ZPR1ZPR1 zinc finger. (447 aa)
NDC80Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SMC5Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (691 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (384 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (941 aa)
PBKProtein kinase domain-containing protein. (322 aa)
CDC16TPR_REGION domain-containing protein. (623 aa)
TFDP1Transcription factor. (411 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
RGCCRegulator of cell cycle. (135 aa)
BRCA2Tower domain-containing protein. (3397 aa)
CCND2G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa)
RAD51AP1Uncharacterized protein. (255 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (324 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (729 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
SMC4Structural maintenance of chromosomes protein. (1300 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
C26H6orf89Uncharacterized protein. (328 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4652 aa)
STRA8Stimulated by retinoic acid 8. (282 aa)
ANAPC5Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa)
TGFAEGF-like domain-containing protein. (156 aa)
LOC769510Uncharacterized protein. (889 aa)
BTCBetacellulin. (171 aa)
CRNNEF-hand domain-containing protein. (384 aa)
MAD2L1BPMAD2L1 binding protein. (282 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
CXCR5Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (662 aa)
USP19Ubiquitin specific peptidase 19. (1434 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa)
LSM11LSM11, U7 small nuclear RNA associated. (361 aa)
RCC2Regulator of chromosome condensation 2. (529 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (488 aa)
UBXN2BUBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Belongs to the NSFL1C family. (402 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
RAD51CRAD51 paralog C. (360 aa)
E2F7E2F transcription factor 7. (923 aa)
PKD2Uncharacterized protein. (881 aa)
NUMA1Uncharacterized protein. (2226 aa)
CUL4BCullin 4B; Belongs to the cullin family. (883 aa)
CEP295ALMS_motif domain-containing protein. (1947 aa)
CCPG1Cell cycle progression protein 1; May be involved in the regulation of Rho-mediated signaling pathways and in cell cycle regulation; Belongs to the CCPG1 family. (801 aa)
CHEK2Uncharacterized protein. (524 aa)
DBF4BDBF4-type domain-containing protein. (395 aa)
ENSGALP00000050097Protein kinase domain-containing protein. (109 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (901 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
ENSGALP00000050982Uncharacterized protein. (280 aa)
NCAPGNon-SMC condensin I complex subunit G. (1038 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC112533511Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (593 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (353 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
NSMCE2SP-RING-type domain-containing protein. (239 aa)
TPRTranslocated promoter region, nuclear basket protein. (2472 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
E2F8E2F transcription factor 8. (738 aa)
MAPK15Mitogen-activated protein kinase. (528 aa)
RACGAP1Rac GTPase activating protein 1. (638 aa)
RASAL3Uncharacterized protein. (1938 aa)
HSF3Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted; Belongs to the HSF family. (551 aa)
ANKRD17Ankyrin repeat domain 17. (2593 aa)
CDC14BUncharacterized protein. (499 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] (343 aa)
CDC25ARhodanese domain-containing protein. (526 aa)
TBX2T-box transcription factor 2. (693 aa)
CCDC57Uncharacterized protein. (588 aa)
GIPC3GIPC PDZ domain containing family member 3. (539 aa)
FAM83DFAM83 domain-containing protein. (562 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
MAD2L1HORMA domain-containing protein. (206 aa)
PLRG1Pleiotropic regulator 1. (516 aa)
THOC1Death domain-containing protein. (671 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (771 aa)
PCID2PCI domain-containing protein. (399 aa)
THOC5THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity); Belongs to t [...] (698 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
STILSTIL centriolar assembly protein. (1330 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
MAP10HPHLAWLY domain-containing protein. (906 aa)
RANBP1RanBD1 domain-containing protein. (252 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
ENSGALP00000066664CYCLIN domain-containing protein; Belongs to the cyclin family. (180 aa)
MAP3K20Uncharacterized protein. (791 aa)
MEPCEMethylphosphate capping enzyme. (628 aa)
STXBP4Syntaxin binding protein 4. (736 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (730 aa)
CEP120Centrosomal protein 120. (1006 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa)
CSPP1Uncharacterized protein. (416 aa)
CDC25BCell division cycle 25B. (555 aa)
RAD51BRAD51 paralog B. (415 aa)
DDX11DEAD/H-box helicase 11. (908 aa)
SVILSupervillin. (2303 aa)
FAM178BUncharacterized protein. (653 aa)
FAM83D-2FAM83 domain-containing protein. (184 aa)
SLF1SMC5-SMC6 complex localization factor 1. (981 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (453 aa)
MECP2Methyl-CpG binding protein 2. (208 aa)
BCL2L11BCL2 like 11. (179 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (727 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
ENSGALP00000071775RING-type domain-containing protein. (343 aa)
SPAG5Uncharacterized protein. (1431 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1374 aa)
GIPC1GIPC PDZ domain containing family member 1. (552 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (369 aa)
MAPK15-2Protein kinase domain-containing protein. (305 aa)
MEIOCMeiosis specific with coiled-coil domain. (911 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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