(32 nodes) Negative regulation of innate immune response network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	SAMHD1	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] (614 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (146 aa)
	DHX58	Uncharacterized protein. (674 aa)
	NLRX1	NLR family member X1. (990 aa)
	SERPING1	Calponin-homology (CH) domain-containing protein; Belongs to the serpin family. (776 aa)
	IRG1L	Uncharacterized protein. (463 aa)
	DRD2	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	SUSD4	Sushi domain containing 4. (330 aa)
	DUSP10	Uncharacterized protein. (478 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa)
	PTPN2	Uncharacterized protein. (597 aa)
	TTLL12	Uncharacterized protein. (627 aa)
	LYAR	Ly1 antibody reactive. (364 aa)
	ACOD1	Uncharacterized protein. (478 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (731 aa)
	YTHDF3	YTH domain-containing protein. (593 aa)
	NLRC3	NLR family CARD domain containing 3. (1095 aa)
	BANF1	Barrier to autointegration factor 1. (90 aa)
	TRAFD1	Uncharacterized protein. (582 aa)
	TNFAIP3	TNF alpha induced protein 3. (806 aa)
	OTOP1	Otopetrin 1. (609 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
	NLRC5	NACHT domain-containing protein. (1862 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (645 aa)
	STAT2	Signal transducer and activator of transcription. (961 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
	GRN	Uncharacterized protein. (287 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (548 aa)
	GFER	Sulfhydryl oxidase. (191 aa)
	NMI	N-myc and STAT interactor. (381 aa)
	VSIG4	V-set and immunoglobulin domain containing 4. (389 aa)
	ADAR	RNA-specific Adenosine deaminase Transcript variant M. (1153 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOD1	IRG1L	ENSGALP00000027300	ENSGALP00000012177	Uncharacterized protein.	Uncharacterized protein.	0.903
ACOD1	TNFAIP3	ENSGALP00000027300	ENSGALP00000046998	Uncharacterized protein.	TNF alpha induced protein 3.	0.488
ADAR	DHX58	ENSGALP00000067956	ENSGALP00000005315	RNA-specific Adenosine deaminase Transcript variant M.	Uncharacterized protein.	0.565
ADAR	SAMHD1	ENSGALP00000067956	ENSGALP00000001866	RNA-specific Adenosine deaminase Transcript variant M.	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...]	0.694
ADAR	STAT2	ENSGALP00000067956	ENSGALP00000052740	RNA-specific Adenosine deaminase Transcript variant M.	Signal transducer and activator of transcription.	0.487
ADAR	YTHDF2	ENSGALP00000067956	ENSGALP00000052726	RNA-specific Adenosine deaminase Transcript variant M.	YTH N6-methyladenosine RNA binding protein 2.	0.427
ATG12	ATG5	ENSGALP00000003688	ENSGALP00000050539	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	NLRX1	ENSGALP00000003688	ENSGALP00000010953	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.535
ATG5	ATG12	ENSGALP00000050539	ENSGALP00000003688	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	NLRX1	ENSGALP00000050539	ENSGALP00000010953	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.587
CNOT7	YTHDF2	ENSGALP00000022159	ENSGALP00000052726	CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...]	YTH N6-methyladenosine RNA binding protein 2.	0.508
CNOT7	YTHDF3	ENSGALP00000022159	ENSGALP00000043825	CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...]	YTH domain-containing protein.	0.527
DHX58	ADAR	ENSGALP00000005315	ENSGALP00000067956	Uncharacterized protein.	RNA-specific Adenosine deaminase Transcript variant M.	0.565
DHX58	NLRC5	ENSGALP00000005315	ENSGALP00000051622	Uncharacterized protein.	NACHT domain-containing protein.	0.601
DHX58	NLRX1	ENSGALP00000005315	ENSGALP00000010953	Uncharacterized protein.	NLR family member X1.	0.449
DHX58	STAT2	ENSGALP00000005315	ENSGALP00000052740	Uncharacterized protein.	Signal transducer and activator of transcription.	0.598
DRD2	OTOP1	ENSGALP00000012625	ENSGALP00000049273	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Otopetrin 1.	0.628
IRG1L	ACOD1	ENSGALP00000012177	ENSGALP00000027300	Uncharacterized protein.	Uncharacterized protein.	0.903
METTL3	YTHDF2	ENSGALP00000058993	ENSGALP00000052726	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N6-methyladenosine RNA binding protein 2.	0.915
METTL3	YTHDF3	ENSGALP00000058993	ENSGALP00000043825	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH domain-containing protein.	0.783