(21 nodes) Positive regulation of mitotic nuclear division network (Gallus gallus)

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Your Input:
	CDC27	Uncharacterized protein. (833 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (565 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	CDC23	Cell division cycle 23. (595 aa)
	EPGN	Epigen; Promotes the growth of epithelial cells. (151 aa)
	EREG	EGF-like domain-containing protein. (153 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	EDN1	Endothelin 1. (194 aa)
	ENSGALP00000071775	RING-type domain-containing protein. (343 aa)
	RB1	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
	NSMCE2	SP-RING-type domain-containing protein. (239 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (662 aa)
	MAD2L1BP	MAD2L1 binding protein. (282 aa)
	BTC	Betacellulin. (171 aa)
	TGFA	EGF-like domain-containing protein. (156 aa)
	ANAPC5	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	RGCC	Regulator of cell cycle. (135 aa)
	CDC16	TPR_REGION domain-containing protein. (623 aa)
	CDT1	Chromatin licensing and DNA replication factor 1. (745 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC5	ANAPC7	ENSGALP00000038461	ENSGALP00000006056	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Anaphase promoting complex subunit 7.	0.998
ANAPC5	CDC16	ENSGALP00000038461	ENSGALP00000027097	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	TPR_REGION domain-containing protein.	0.998
ANAPC5	CDC23	ENSGALP00000038461	ENSGALP00000012291	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Cell division cycle 23.	0.998
ANAPC5	CDC27	ENSGALP00000038461	ENSGALP00000000830	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Uncharacterized protein.	0.999
ANAPC5	CDT1	ENSGALP00000038461	ENSGALP00000022344	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Chromatin licensing and DNA replication factor 1.	0.440
ANAPC5	ENSGALP00000071775	ENSGALP00000038461	ENSGALP00000071775	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	RING-type domain-containing protein.	0.998
ANAPC5	RB1	ENSGALP00000038461	ENSGALP00000071459	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...]	0.499
ANAPC7	ANAPC5	ENSGALP00000006056	ENSGALP00000038461	Anaphase promoting complex subunit 7.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.998
ANAPC7	CDC16	ENSGALP00000006056	ENSGALP00000027097	Anaphase promoting complex subunit 7.	TPR_REGION domain-containing protein.	0.995
ANAPC7	CDC23	ENSGALP00000006056	ENSGALP00000012291	Anaphase promoting complex subunit 7.	Cell division cycle 23.	0.993
ANAPC7	CDC27	ENSGALP00000006056	ENSGALP00000000830	Anaphase promoting complex subunit 7.	Uncharacterized protein.	0.998
ANAPC7	CDT1	ENSGALP00000006056	ENSGALP00000022344	Anaphase promoting complex subunit 7.	Chromatin licensing and DNA replication factor 1.	0.465
ANAPC7	ENSGALP00000071775	ENSGALP00000006056	ENSGALP00000071775	Anaphase promoting complex subunit 7.	RING-type domain-containing protein.	0.946
ANAPC7	RB1	ENSGALP00000006056	ENSGALP00000071459	Anaphase promoting complex subunit 7.	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...]	0.526
BTC	EPGN	ENSGALP00000041051	ENSGALP00000017636	Betacellulin.	Epigen; Promotes the growth of epithelial cells.	0.933
BTC	EREG	ENSGALP00000041051	ENSGALP00000017642	Betacellulin.	EGF-like domain-containing protein.	0.975
BTC	TGFA	ENSGALP00000041051	ENSGALP00000039726	Betacellulin.	EGF-like domain-containing protein.	0.534
CDC16	ANAPC5	ENSGALP00000027097	ENSGALP00000038461	TPR_REGION domain-containing protein.	Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).	0.998
CDC16	ANAPC7	ENSGALP00000027097	ENSGALP00000006056	TPR_REGION domain-containing protein.	Anaphase promoting complex subunit 7.	0.995
CDC16	CDC23	ENSGALP00000027097	ENSGALP00000012291	TPR_REGION domain-containing protein.	Cell division cycle 23.	0.999