STRINGSTRING
CDC20B CDC20B AXIN1 AXIN1 ENSGALP00000073564 ENSGALP00000073564 COP1 COP1 GPLD1 GPLD1 DAB2 DAB2 NUB1 NUB1 MYC MYC LRRC27 LRRC27 DDA1 DDA1 PRKN PRKN USP50 USP50 RIPK3 RIPK3 BCL2L11 BCL2L11 PSMC5 PSMC5 LOC112531384 LOC112531384 LOC107050229 LOC107050229 PACSIN3 PACSIN3 LCK LCK HERPUD1 HERPUD1 CASP9 CASP9 CARD9 CARD9 TMEM259 TMEM259 APH1B APH1B PCOLCE2 PCOLCE2 SIRT1 SIRT1 PRELID1 PRELID1 FASLG FASLG FN1 FN1 CYFIP2 CYFIP2 AIFM1 AIFM1 GPER1 GPER1 DIABLO DIABLO TNIP1 TNIP1 PDCD5 PDCD5 SMURF1 SMURF1 ZER1 ZER1 RHBDD1 RHBDD1 MKRN2 MKRN2 KLHL40 KLHL40 F3 F3 PLK1 PLK1 FAM122A FAM122A MUL1L MUL1L CTSD CTSD DET1 DET1 CLPX CLPX FADD FADD CLN6 CLN6 HSPD1 HSPD1 PSME4 PSME4 FBXW8 FBXW8 RNFT2 RNFT2 CFLAR CFLAR PSMD10 PSMD10 CAV3 CAV3 CASP8 CASP8 CYR61 CYR61 USP13 USP13 NCSTN NCSTN FMR1 FMR1 SH3RF1 SH3RF1 CDC20 CDC20 SOCS5 SOCS5 NRDC NRDC ZYG11A ZYG11A PSMC1 PSMC1 LGMN LGMN CYCS CYCS PSMD14 PSMD14 TMTC3 TMTC3 BBS7 BBS7 RNF144B RNF144B DAP DAP SNX9 SNX9 FBLN1 FBLN1 FAM162A FAM162A USP5 USP5 CLUL1 CLUL1 ACER2 ACER2 IFT57 IFT57 CASP8AP2 CASP8AP2 FGFR4 FGFR4 AKIRIN2 AKIRIN2 EIF2AK3 EIF2AK3 DDRGK1 DDRGK1 GCLC GCLC RNF19AL RNF19AL PTK2B PTK2B CTSC CTSC RPS3 RPS3 LOC419074 LOC419074 CASP2 CASP2 WDR48 WDR48 FGF2 FGF2 FZR1 FZR1 TRIB2 TRIB2 APAF1 APAF1 RCHY1 RCHY1 PSMC3 PSMC3 FAS FAS TNFSF15 TNFSF15 TMEM130 TMEM130 ECSCR ECSCR S100A10 S100A10 ARIH2 ARIH2 TFAP4 TFAP4 RNF144A RNF144A BAG2 BAG2 CCBE1 CCBE1 ADRM1 ADRM1 CAV1 CAV1 SIRT2 SIRT2 ASPH-2 ASPH-2 FBXW11 FBXW11 CSNK1D CSNK1D ASPH ASPH ST18 ST18 ENSGALP00000045724 ENSGALP00000045724 OGT OGT MALT1 MALT1 RIPK2 RIPK2 ASTL ASTL LYN LYN ZC3H12A ZC3H12A BTRC BTRC RNF19A RNF19A ENSGALP00000047627 ENSGALP00000047627 C6H10orf54 C6H10orf54 HSPBP1 HSPBP1 DISC1 DISC1 BID BID PMAIP1 PMAIP1 SGTA SGTA IL1B IL1B SART3 SART3 RNF139 RNF139 FBXW7 FBXW7 HIP1R HIP1R UACA UACA PRR7 PRR7 TRIB1 TRIB1 CTSH CTSH ARIH1 ARIH1 ARL6IP5 ARL6IP5 HTRA2 HTRA2 LRRK2 LRRK2 HIP1 HIP1 CSNK1E CSNK1E PCASP3 PCASP3 RNF14 RNF14 MUL1 MUL1 CAPN3 CAPN3 MYH9 MYH9 FBXO22 FBXO22 GRN GRN SMAD7 SMAD7 AXIN2 AXIN2 CLDN9 CLDN9 KCNE2 KCNE2 BAK1 BAK1 TNFRSF8 TNFRSF8 LAPTM5 LAPTM5 GRAMD4 GRAMD4 TNFRSF1B TNFRSF1B CLEC3B CLEC3B SMAD7B SMAD7B TRIM67 TRIM67 NOP53 NOP53 SOX7 SOX7 PCASP2 PCASP2 STUB1 STUB1 ANKIB1 ANKIB1 UVS.2L UVS.2L IST1 IST1 PSMC2 PSMC2 LPCAT3 LPCAT3 SH3RF2 SH3RF2 TNFSF10 TNFSF10 SIRT6 SIRT6 PSME3 PSME3 CASP10 CASP10 PSMC6 PSMC6 PMLL PMLL SOCS4 SOCS4 CSNK1A1 CSNK1A1 CASP18 CASP18 LOC107049673 LOC107049673 ROCK2 ROCK2 SH3D19 SH3D19 RNFT1 RNFT1 ACVR1C ACVR1C APH1A APH1A SH3RF3 SH3RF3 GSK3B GSK3B WDR20 WDR20 RNF19B RNF19B REST REST TTBK1 TTBK1 FBXW9 FBXW9 ENSGALP00000068079 ENSGALP00000068079 RNF217 RNF217 TANK TANK RNF180 RNF180 ENSGALP00000069448 ENSGALP00000069448 AURKAIP1 AURKAIP1 PSEN1 PSEN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC20BCell division cycle 20B. (403 aa)
AXIN1Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa)
ENSGALP00000073564Uncharacterized protein. (243 aa)
COP1COP1 E3 ubiquitin ligase. (723 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
DAB2DAB adaptor protein 2. (715 aa)
NUB1Uncharacterized protein. (611 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
LRRC27Death domain-containing protein. (291 aa)
DDA1DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
USP50UCH domain-containing protein. (115 aa)
RIPK3Uncharacterized protein. (424 aa)
BCL2L11BCL2 like 11. (179 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
LOC112531384AAA_lid_3 domain-containing protein. (110 aa)
LOC107050229Glucosylceramidase. (538 aa)
PACSIN3Uncharacterized protein. (458 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
CARD9Caspase recruitment domain family member 9. (574 aa)
TMEM259Transmembrane protein 259. (738 aa)
APH1BUncharacterized protein. (256 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (408 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The TRIAP1:PRELID1 complex probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (By similarity). May be involved in hematopoiesis during avian development. (215 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
AIFM1Uncharacterized protein. (689 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
DIABLOUncharacterized protein. (240 aa)
TNIP1TNFAIP3 interacting protein 1. (614 aa)
PDCD5Uncharacterized protein. (126 aa)
SMURF1E3 ubiquitin-protein ligase. (744 aa)
ZER1Zyg-11 related cell cycle regulator. (766 aa)
RHBDD1Rhomboid domain containing 1. (317 aa)
MKRN2Uncharacterized protein. (417 aa)
KLHL40Kelch like family member 40. (587 aa)
F3Coagulation factor III, tissue factor. (283 aa)
PLK1Serine/threonine-protein kinase PLK. (595 aa)
FAM122AProtein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). (284 aa)
MUL1LRING-type domain-containing protein. (418 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
DET1Uncharacterized protein. (551 aa)
CLPXUncharacterized protein. (630 aa)
FADDFas associated via death domain. (195 aa)
CLN6Uncharacterized protein. (317 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
PSME4Uncharacterized protein. (1821 aa)
FBXW8F-box and WD repeat domain containing 8. (582 aa)
RNFT2Ring finger protein, transmembrane 2. (448 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (493 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CYR61CCN family member 1; Probable secreted regulatory protein. (375 aa)
USP13Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (862 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
FMR1Fragile X mental retardation 1. (548 aa)
SH3RF1SH3 domain containing ring finger 1. (872 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (507 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
NRDCUncharacterized protein; Belongs to the peptidase M16 family. (1159 aa)
ZYG11AZyg-11 family member B, cell cycle regulator. (735 aa)
PSMC126S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. (529 aa)
LGMNLegumain. (431 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PSMD14MPN domain-containing protein. (310 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (939 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (716 aa)
RNF144BRBR-type E3 ubiquitin transferase. (302 aa)
DAPDeath associated protein 1. (104 aa)
SNX9Sorting nexin. (600 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa)
FAM162AFamily with sequence similarity 162 member A. (151 aa)
USP5Ubiquitin carboxyl-terminal hydrolase. (832 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
IFT57Intraflagellar transport 57. (532 aa)
CASP8AP2Caspase 8 associated protein 2. (2028 aa)
FGFR4Fibroblast growth factor receptor. (803 aa)
AKIRIN2Akirin. (191 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
DDRGK1DDRGK domain containing 1. (221 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (636 aa)
RNF19ALRBR-type E3 ubiquitin transferase. (525 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (992 aa)
CTSCPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
LOC419074Uncharacterized protein. (765 aa)
CASP2Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
FZR1WD_REPEATS_REGION domain-containing protein. (493 aa)
TRIB2TRB2 protein. (343 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1. (256 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
FASUncharacterized protein. (339 aa)
TNFSF15TL1A. (239 aa)
TMEM130Transmembrane protein 130. (425 aa)
ECSCRUncharacterized protein. (234 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
ARIH2RBR-type E3 ubiquitin transferase. (490 aa)
TFAP4Transcription factor AP-4. (338 aa)
RNF144ARBR-type E3 ubiquitin transferase. (292 aa)
BAG2BCL2 associated athanogene 2. (224 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] (405 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
ASPH-2Asp-B-Hydro_N domain-containing protein. (350 aa)
FBXW11Uncharacterized protein. (531 aa)
CSNK1DProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
ASPHAspartate beta-hydroxylase. (295 aa)
ST18ST18 C2H2C-type zinc finger transcription factor. (1144 aa)
ENSGALP00000045724Uncharacterized protein. (235 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
MALT1MALT1 paracaspase. (816 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
ASTLAstacin-like metalloendopeptidase; Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity). (409 aa)
LYNTyrosine-protein kinase. (491 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (681 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa)
RNF19ARBR-type E3 ubiquitin transferase. (820 aa)
ENSGALP00000047627Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
C6H10orf54Ig-like domain-containing protein. (310 aa)
HSPBP1Uncharacterized protein. (330 aa)
DISC1DISC1 scaffold protein. (856 aa)
BIDBH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa)
PMAIP1Uncharacterized protein. (54 aa)
SGTATPR_REGION domain-containing protein. (312 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (943 aa)
RNF139RING-type domain-containing protein. (677 aa)
FBXW7Uncharacterized protein. (586 aa)
HIP1RUncharacterized protein. (977 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1402 aa)
PRR7Proline rich 7, synaptic. (231 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
ARIH1RBR-type E3 ubiquitin transferase. (552 aa)
ARL6IP5PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity- dependent manner. May be involved in membrane traffic. (187 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
LRRK2Uncharacterized protein. (2557 aa)
HIP1Huntingtin interacting protein 1. (1008 aa)
CSNK1ECasein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity). (416 aa)
PCASP3Uncharacterized protein. (632 aa)
RNF14RBR-type E3 ubiquitin transferase. (470 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
FBXO22FIST_C domain-containing protein. (393 aa)
GRNUncharacterized protein. (287 aa)
SMAD7Mothers against decapentaplegic homolog. (388 aa)
AXIN2Uncharacterized protein. (837 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (214 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (125 aa)
BAK1Uncharacterized protein. (216 aa)
TNFRSF8TNFR-Cys domain-containing protein. (467 aa)
LAPTM5Lysosomal protein transmembrane 5. (256 aa)
GRAMD4GRAM domain containing 4. (568 aa)
TNFRSF1BUncharacterized protein. (462 aa)
CLEC3BTetranectin. (201 aa)
SMAD7BMothers against decapentaplegic homolog. (388 aa)
TRIM67Tripartite motif containing 67. (717 aa)
NOP53NOP53 ribosome biogenesis factor. (598 aa)
SOX7Uncharacterized protein. (377 aa)
PCASP2Uncharacterized protein. (741 aa)
STUB1STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1064 aa)
UVS.2LMetalloendopeptidase. (281 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (501 aa)
SH3RF2SH3 domain containing ring finger 2. (644 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (455 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
PMLLUncharacterized protein. (464 aa)
SOCS4Uncharacterized protein. (436 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
LOC107049673Glucosylceramidase. (298 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
SH3D19SH3 domain containing 19. (1123 aa)
RNFT1Ring finger protein, transmembrane 1. (421 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (311 aa)
SH3RF3SH3 domain containing ring finger 3. (736 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
WDR20WD repeat domain 20. (592 aa)
RNF19BRing finger protein 19B. (406 aa)
RESTUncharacterized protein. (339 aa)
TTBK1Protein kinase domain-containing protein. (1419 aa)
FBXW9F-box domain-containing protein. (337 aa)
ENSGALP00000068079Ephrin RBD domain-containing protein; Belongs to the ephrin family. (286 aa)
RNF217RBR-type E3 ubiquitin transferase. (453 aa)
TANKTBD domain-containing protein. (422 aa)
RNF180Ring finger protein 180. (609 aa)
ENSGALP00000069448Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (409 aa)
AURKAIP1DUF1713 domain-containing protein. (202 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.