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| | HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (474 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (293 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (455 aa) |
| | ACAD8 | Uncharacterized protein. (472 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (662 aa) |
| | HSD17B4 | 17-beta-hydroxysteroid dehydrogenase type IV. (735 aa) |
| | CDO1 | Cysteine dioxygenase. (204 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (560 aa) |
| | SRRL | ACT domain-containing protein. (536 aa) |
| | DECR2 | 2,4-dienoyl-CoA reductase 2. (348 aa) |
| | PGD | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa) |
| | ETFA | ETF domain-containing protein. (346 aa) |
| | AADACL3C | Uncharacterized protein. (411 aa) |
| | BLMH | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. (455 aa) |
| | HPD | 4-hydroxyphenylpyruvate dioxygenase. (393 aa) |
| | CCBL1 | Aminotran_1_2 domain-containing protein. (426 aa) |
| | NPL | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). (328 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (802 aa) |
| | ACAD9 | Uncharacterized protein. (614 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | ABCD3 | Uncharacterized protein. (660 aa) |
| | ACAA1 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) |
| | FTCD | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. (541 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (326 aa) |
| | FAH | Fumarylacetoacetase. (419 aa) |
| | ACOT8 | Acyl-CoA thioesterase 8. (372 aa) |
| | CPT1A | Carnitine palmitoyltransferase I; Belongs to the carnitine/choline acetyltransferase family. (770 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (675 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (412 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (486 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | LOC427595 | Uncharacterized protein. (537 aa) |
| | PRODH | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (602 aa) |
| | PEX13 | SH3 domain-containing protein. (397 aa) |
| | DDAH1 | Uncharacterized protein. (322 aa) |
| | CROT | Carnitine O-octanoyltransferase. (612 aa) |
| | HAO1 | FMN hydroxy acid dehydrogenase domain-containing protein. (369 aa) |
| | AMDHD2 | N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (409 aa) |
| | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (619 aa) |
| | ARG2 | Arginase. (356 aa) |
| | AADAT | Aminoadipate aminotransferase. (428 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa) |
| | ALDH6A1 | Aldehyde dehydrogenase 6 family member A1. (506 aa) |
| | ABCD4 | ATP binding cassette subfamily D member 4. (572 aa) |
| | GSTZ1 | Uncharacterized protein; Belongs to the GST superfamily. (266 aa) |
| | ECHDC2 | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa) |
| | SCP2 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. (534 aa) |
| | HACL1 | Uncharacterized protein; Belongs to the TPP enzyme family. (568 aa) |
| | MCCC2L | Uncharacterized protein. (606 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (435 aa) |
| | ACAT2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | SLC25A17 | Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (335 aa) |
| | GCAT | Glycine C-acetyltransferase. (419 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase 2. (245 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (530 aa) |
| | ALDH1L2 | 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (922 aa) |
| | PAH | Phenylalanine hydroxylase. (446 aa) |
| | ECI2 | Enoyl-CoA delta isomerase 2. (401 aa) |
| | AIG1 | Androgen induced 1. (238 aa) |
| | PEX7 | WD_REPEATS_REGION domain-containing protein. (360 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (406 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (439 aa) |
| | DDO | D-aspartate oxidase. (342 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (706 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | LOC418544 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (532 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (338 aa) |
| | HADHA | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (770 aa) |
| | TDH | Epimerase domain-containing protein. (373 aa) |
| | PCCA | Propionyl-CoA carboxylase subunit alpha. (713 aa) |
| | ACAT1 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa) |
| | MCCC1 | Uncharacterized protein. (758 aa) |
| | CRABP1 | Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. (137 aa) |
| | HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. (348 aa) |
| | CPT2 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (652 aa) |
| | GLDC | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH); Belongs to the GcvP family. (1004 aa) |
| | HDC | Uncharacterized protein. (664 aa) |
| | IDO2 | Uncharacterized protein. (383 aa) |
| | LOC101747660 | Beta_elim_lyase domain-containing protein. (429 aa) |
| | FAAH2 | Fatty acid amide hydrolase 2. (534 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (504 aa) |
| | GLUD2 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa) |
| | BCKDHA | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (448 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (233 aa) |
| | CYP26A1 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa) |
| | PCCB | Propionyl-CoA carboxylase subunit beta. (529 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (478 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa) |
| | ECI1 | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (366 aa) |
| | ACAD11 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates to beta-oxydation and energy production but could also play role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain. (778 aa) |
| | GNPDA2 | Glucosamine-6-phosphate isomerase. (275 aa) |
| | IVD | Uncharacterized protein. (422 aa) |
| | GNPDA1 | Glucosamine-6-phosphate isomerase. (288 aa) |
| | ACADSB | Uncharacterized protein. (433 aa) |
| | GCSH | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. (164 aa) |
| | BCKDHB | Transket_pyr domain-containing protein. (390 aa) |
| | PRODH2 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (161 aa) |
| | NUDT19 | Nucleoside diphosphate-linked moiety X motif 19; Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty- acyl-CoA esters. (378 aa) |
| | DECR1 | 2,4-dienoyl-CoA reductase 1. (336 aa) |
| | ECH1 | Enoyl-CoA hydratase 1. (516 aa) |
| | ALDH5A1 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (548 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. (385 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (335 aa) |
| | ABCD2 | Uncharacterized protein. (730 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (418 aa) |
| | ENSGALP00000053038 | Uncharacterized protein. (252 aa) |
| | SESN2 | Uncharacterized protein. (474 aa) |
| | PHYH | Phytanoyl-CoA 2-hydroxylase. (328 aa) |
| | OAT | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa) |
| | GAD1 | Glutamate decarboxylase 67. (590 aa) |
| | ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (544 aa) |
| | GLS2 | ANK_REP_REGION domain-containing protein. (667 aa) |
| | ADHFE1 | Fe-ADH domain-containing protein. (465 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (693 aa) |
| | GAD2 | Glutamate decarboxylase 2. (807 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (928 aa) |
| | DLST | Lipoyl-binding domain-containing protein. (474 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (482 aa) |
| | SARDH | Sarcosine dehydrogenase. (463 aa) |
| | LPIN2 | LNS2 domain-containing protein. (918 aa) |
| | QDPR | Uncharacterized protein. (238 aa) |
| | PEX2 | RING-type domain-containing protein. (304 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (551 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity); Belongs to the NOS family. (1136 aa) |
| | DAO | D-amino acid oxidase. (348 aa) |
| | AADACL3A | Abhydrolase_3 domain-containing protein. (369 aa) |
| | NUDT7 | Nudix hydrolase domain-containing protein. (307 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (665 aa) |
| | AADACL4B | Uncharacterized protein. (404 aa) |
| | FAAH | Amidase domain-containing protein. (576 aa) |
| | ACADS | Uncharacterized protein. (489 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. May facilitate cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (427 aa) |
| | HADH | Uncharacterized protein. (350 aa) |
| | ACADL | Uncharacterized protein. (437 aa) |
| | LPIN1 | Lipin 1. (1003 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (425 aa) |
| | NUDT8 | Uncharacterized protein. (105 aa) |
| | IL4I1 | Amine oxidase. (523 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase. (476 aa) |
| | ABAT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa) |
| | ENSGALP00000068191 | Uncharacterized protein. (1629 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (316 aa) |
| | ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (396 aa) |
| | IDNK | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (227 aa) |
| | ENSGALP00000068833 | SHMT domain-containing protein. (497 aa) |
| | QPRT | Quinolinate phosphoribosyltransferase. (339 aa) |
| | AUH | Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (350 aa) |
| | PODN | Podocan. (632 aa) |
| | AADACL3B | Uncharacterized protein. (410 aa) |
| | SDSL | Uncharacterized protein. (514 aa) |
| | ENSGALP00000070065 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (154 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (809 aa) |
| | ECHDC1 | Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa) |
| | SLC25A44 | Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (660 aa) |
| | VDHAP | Vitamin D3 hydroxylase-associated protein; May have a vitamin D3 hydroxylase regulatory function. (613 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (726 aa) |
| | CBSL | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (577 aa) |
| | LOC429098 | Amidase domain-containing protein. (573 aa) |
| | PPARD | Uncharacterized protein. (545 aa) |
| | ENSGALP00000073164 | LNS2 domain-containing protein. (153 aa) |
| | LOC420562 | Uncharacterized protein. (455 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa) |
