STRINGSTRING
RC3H1 RC3H1 CD79B CD79B LCK LCK SOX13 SOX13 RAB29 RAB29 RC3H2 RC3H2 IL12B IL12B ZAP70 ZAP70 CD276 CD276 PRKCD PRKCD STOML2 STOML2 PIK3CD PIK3CD DEF6 DEF6 CBFB CBFB STAT5A STAT5A ATAD5 ATAD5 MTOR MTOR E1C066_CHICK E1C066_CHICK FOXN1 FOXN1 P2RX7 P2RX7 ABL1 ABL1 ITM2A ITM2A ADA ADA CARD11 CARD11 IRF8 IRF8 F1NCI0_CHICK F1NCI0_CHICK CD40LG CD40LG CRTAM CRTAM CD81 CD81 POU2AF1 POU2AF1 BCL6 BCL6 CD3E CD3E FADD FADD EGR1 EGR1 KIAA1841 KIAA1841 IL18 IL18 HSPD1 HSPD1 FGL2 FGL2 DLL4 DLL4 CD28 CD28 GPAM GPAM MSH2 MSH2 NCSTN NCSTN EIF2AK4 EIF2AK4 HECTD1 HECTD1 DOCK8 DOCK8 BATF BATF TSHR TSHR EXO1 EXO1 AZI2 AZI2 CMTM7 CMTM7 CCR9 CCR9 IL21 IL21 LOC768614 LOC768614 EP300 EP300 BANK1 BANK1 CG-1B CG-1B MFNG MFNG IL2RB IL2RB FBXO7 FBXO7 BCL2 BCL2 JAG2 JAG2 NTRK1 NTRK1 IL7R IL7R IKZF3 IKZF3 PTPN2 PTPN2 AICDA AICDA ITFG2 ITFG2 GON4L GON4L RABL3 RABL3 TRAF3IP2 TRAF3IP2 NFIL3 NFIL3 GPR89A GPR89A CD8A CD8A CYP26B1 CYP26B1 PKNOX1 PKNOX1 LRRC1 LRRC1 RSAD2 RSAD2 TNFSF13B TNFSF13B GPR183 GPR183 ATM ATM TSTD1 TSTD1 ANXA1 ANXA1 IFNKL1 IFNKL1 LEPR LEPR HDAC4 HDAC4 UNG UNG TREM-B2 TREM-B2 GPR18 GPR18 CD86 CD86 ZBTB1 ZBTB1 CD180 CD180 CD40 CD40 NTN1 NTN1 IFNW1 IFNW1 PELI3 PELI3 EOMES EOMES FKBP1A FKBP1A CXCR5 CXCR5 CCL19-2 CCL19-2 LRRC8A LRRC8A CDH17 CDH17 CG-16 CG-16 NLRC3 NLRC3 LFNG LFNG CTNNB1 CTNNB1 MSN MSN RNF8 RNF8 LOC112532337 LOC112532337 SP3 SP3 MLH1 MLH1 THEMIS THEMIS MALT1 MALT1 LAT2 LAT2 RIPK2 RIPK2 CHD9 CHD9 ENSGALP00000048186 ENSGALP00000048186 LOC100857714 LOC100857714 CCR7 CCR7 NKX2-3 NKX2-3 NKX2-6 NKX2-6 RORC RORC FKBP1B FKBP1B ATG5 ATG5 FZD7 FZD7 KIT KIT PRR7 PRR7 CD48 CD48 IL7 IL7 ABL2 ABL2 DPP4 DPP4 DCAF1 DCAF1 SKAP2 SKAP2 PCASP3 PCASP3 IL4R IL4R IL2RG IL2RG TPD52 TPD52 MYH9 MYH9 MERTK MERTK FLT3 FLT3 SRF SRF CEBPG CEBPG ITCH ITCH BAK1 BAK1 PTPRC PTPRC RAG1 RAG1 TMEM98 TMEM98 CHD7 CHD7 PCASP2 PCASP2 BCL11B BCL11B IL6R IL6R TESPA1 TESPA1 HLX HLX SASH3 SASH3 PLA2G2A PLA2G2A TCD8AL4 TCD8AL4 RAG2 RAG2 CD8A-2 CD8A-2 ENSGALP00000060244 ENSGALP00000060244 LOC100858506 LOC100858506 ENSGALP00000060489 ENSGALP00000060489 LOC107049200 LOC107049200 ENSGALP00000061280 ENSGALP00000061280 LOC771804 LOC771804 RASGRP1 RASGRP1 SH2D2A SH2D2A LOC771880 LOC771880 K4LB56_CHICK K4LB56_CHICK CD74 CD74 CD244 CD244 ENSGALP00000063593 ENSGALP00000063593 CD83 CD83 ENSGALP00000064025 ENSGALP00000064025 LOC107053306 LOC107053306 NRARP NRARP TNFSF8 TNFSF8 PTGER4 PTGER4 LOC112530215 LOC112530215 TSPAN32 TSPAN32 TCF7 TCF7 CLCF1 CLCF1 CD4 CD4 SLA2 SLA2 ENSGALP00000065981 ENSGALP00000065981 ENSGALP00000066108 ENSGALP00000066108 ENSGALP00000066325 ENSGALP00000066325 NCK1 NCK1 LOC107049158 LOC107049158 LOC100859414 LOC100859414 EMP2 EMP2 DLL1 DLL1 ENSGALP00000067311 ENSGALP00000067311 TOX TOX EXOSC3 EXOSC3 IL6 IL6 CD2 CD2 CCL19 CCL19 HELLS HELLS TSC1 TSC1 ENSGALP00000068651 ENSGALP00000068651 ENSGALP00000068753 ENSGALP00000068753 ENSGALP00000068805 ENSGALP00000068805 GATA3 GATA3 ARMC5 ARMC5 ENSGALP00000069003 ENSGALP00000069003 IL15 IL15 LOC100858177 LOC100858177 TUSC2 TUSC2 LOC776018 LOC776018 PSEN1 PSEN1 FYN FYN DOCK10 DOCK10 ENSGALP00000069955 ENSGALP00000069955 LOC112529934 LOC112529934 TBX21 TBX21 IFNA3 IFNA3 RASSF5 RASSF5 CD6 CD6 SH2D6 SH2D6 LOC100857744 LOC100857744 NCAPH2 NCAPH2 LOC100859032 LOC100859032 RIPK3 RIPK3 NFAM1 NFAM1 LOC100857947 LOC100857947 IRF9 IRF9 LOC107050371 LOC107050371 DNAJB9 DNAJB9 CD8A-3 CD8A-3 LOC100857403 LOC100857403 CD3D CD3D RORA RORA TNFRSF4 TNFRSF4 ENSGALP00000072274 ENSGALP00000072274 ENSGALP00000072433 ENSGALP00000072433 ENSGALP00000072723 ENSGALP00000072723 LOC396098 LOC396098 LOC100858762 LOC100858762 ENSGALP00000073054 ENSGALP00000073054 PTPN6 PTPN6 LOC771880-2 LOC771880-2 LOC112530959 LOC112530959 RHOH RHOH ENSGALP00000073699 ENSGALP00000073699 RNF168 RNF168 LEF1 LEF1 STAT6 STAT6 TXLNA TXLNA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RC3H1Ring finger and CCCH-type domains 1. (1114 aa)
CD79BB29/Ig-b. (226 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
SOX13SRY-box transcription factor 13. (666 aa)
RAB29RAB29, member RAS oncogene family. (205 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
IL12BInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
CD276Uncharacterized protein. (314 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
STOML2Stomatin like 2. (382 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
DEF6DEF6 guanine nucleotide exchange factor. (625 aa)
CBFBUncharacterized protein. (187 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
ATAD5AAA domain-containing protein. (1816 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
FOXN1Forkhead box N1. (636 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
ABL1Tyrosine-protein kinase. (1111 aa)
ITM2ABRICHOS domain-containing protein. (251 aa)
ADAAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (357 aa)
CARD11Uncharacterized protein. (1170 aa)
IRF8Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa)
F1NCI0_CHICKDUF4704 domain-containing protein. (1936 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
CRTAMUncharacterized protein. (439 aa)
CD81Tetraspanin. (237 aa)
POU2AF1Oct binding factor 1. (256 aa)
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; The CD3 complex mediates signal transduction, resulting in T- cell activation and proliferation. Required for normal immune responses. (175 aa)
FADDFas associated via death domain. (195 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
KIAA1841DUF3342 domain-containing protein. (718 aa)
IL18Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
HSPD160 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
FGL2Fibrinogen C-terminal domain-containing protein. (439 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
CD28T-cell-specific surface glycoprotein CD28 homolog; Possibly involved in T-cell activation. (304 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (942 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1656 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2570 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2036 aa)
BATFBasic leucine zipper ATF-like transcription factor. (286 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
EXO1Uncharacterized protein. (800 aa)
AZI25-azacytidine induced 2. (397 aa)
CMTM7MARVEL domain-containing protein. (174 aa)
CCR9G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
LOC768614Interferon type A3; Has antiviral activities; Belongs to the alpha/beta interferon family. (193 aa)
EP300E1A binding protein p300. (2450 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (730 aa)
CG-1BBeta-galactoside-binding lectin; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins. (135 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (352 aa)
IL2RBFibronectin type-III domain-containing protein. (576 aa)
FBXO7F-box domain-containing protein. (526 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1300 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
IL7RInterleukin-7 receptor alpha chain. (460 aa)
IKZF3Uncharacterized protein. (509 aa)
PTPN2Uncharacterized protein. (597 aa)
AICDACMP/dCMP-type deaminase domain-containing protein. (198 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (460 aa)
GON4LUncharacterized protein. (1044 aa)
RABL3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (236 aa)
TRAF3IP2SEFIR domain-containing protein. (532 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator (By similarity). Represses PER2 transcription through a recognition sequence in the promoter. Component of the circadian clock that may contribute to the rhythmic expression of PER2 gene in a light-dependent and time-of-day-dependent manner. (458 aa)
GPR89AGolgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. (455 aa)
CD8AIg-like domain-containing protein. (207 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
RSAD2Viperin. (354 aa)
TNFSF13BTNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
TSTD1Uncharacterized protein. (358 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
IFNKL1Uncharacterized protein. (197 aa)
LEPRUncharacterized protein. (1148 aa)
HDAC4Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (1080 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
TREM-B2Uncharacterized protein. (601 aa)
GPR18G protein-coupled receptor 18; Belongs to the G-protein coupled receptor 1 family. (320 aa)
CD86Uncharacterized protein. (319 aa)
ZBTB1Zinc finger and BTB domain containing 1. (711 aa)
CD180CD180 molecule. (708 aa)
CD40Uncharacterized protein. (299 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
IFNW1Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa)
PELI3Uncharacterized protein. (418 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
FKBP1APeptidylprolyl isomerase. (108 aa)
CXCR5Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
CCL19-2SCY domain-containing protein. (99 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
CDH17Uncharacterized protein. (835 aa)
CG-1616 kDa beta-galactoside-binding lectin; This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation. (126 aa)
NLRC3NLR family CARD domain containing 3. (1095 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa)
CTNNB1Uncharacterized protein. (781 aa)
MSNMoesin. (580 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (529 aa)
LOC112532337Ig-like domain-containing protein. (215 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
MLH1DNA mismatch repair protein MLH1. (757 aa)
THEMISThymocyte selection associated. (776 aa)
MALT1MALT1 paracaspase. (816 aa)
LAT2Linker for activation of T-cells family member 2; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2. (198 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
LOC100857714Uncharacterized protein. (383 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
NKX2-6Homeobox domain-containing protein. (193 aa)
RORCRAR related orphan receptor C. (461 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
FZD7Frizzled-7; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (567 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
PRR7Proline rich 7, synaptic. (231 aa)
CD48CD48. (249 aa)
IL7Interleukin-7. (146 aa)
ABL2Tyrosine-protein kinase. (1159 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1505 aa)
SKAP2Src kinase associated phosphoprotein 2. (391 aa)
PCASP3Uncharacterized protein. (632 aa)
IL4RFibronectin type-III domain-containing protein. (996 aa)
IL2RGFibronectin type-III domain-containing protein. (384 aa)
TPD52Uncharacterized protein. (184 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
MERTKUncharacterized protein. (990 aa)
FLT3Fms related tyrosine kinase 3. (877 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
CEBPGLeucine zipper transcription factor. (150 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
BAK1Uncharacterized protein. (216 aa)
PTPRCUncharacterized protein. (1237 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa)
TMEM98Transmembrane protein 98. (222 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
PCASP2Uncharacterized protein. (741 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (884 aa)
IL6RUncharacterized protein. (445 aa)
TESPA1KRAP_IP3R_bind domain-containing protein. (600 aa)
HLXH2.0 like homeobox. (431 aa)
SASH3Uncharacterized protein. (382 aa)
PLA2G2APhospholipase A(2). (144 aa)
TCD8AL4Ig-like domain-containing protein. (212 aa)
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (535 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
ENSGALP00000060244Ig-like domain-containing protein. (234 aa)
LOC100858506Interferon alpha. (193 aa)
ENSGALP00000060489Hist_deacetyl domain-containing protein. (316 aa)
LOC107049200Ig-like domain-containing protein. (155 aa)
ENSGALP00000061280Ig-like domain-containing protein. (218 aa)
LOC771804Ig-like domain-containing protein. (241 aa)
RASGRP1RAS guanyl releasing protein 1. (480 aa)
SH2D2ASH2 domain-containing protein. (524 aa)
LOC771880Ig-like domain-containing protein. (228 aa)
K4LB56_CHICKCD150. (333 aa)
CD74Invariant chain isoform p41. (286 aa)
CD244Ig-like domain-containing protein. (383 aa)
ENSGALP00000063593Ig-like domain-containing protein. (234 aa)
CD83CD83 molecule. (215 aa)
ENSGALP00000064025Ig-like domain-containing protein. (224 aa)
LOC107053306Ig-like domain-containing protein. (212 aa)
NRARPNOTCH regulated ankyrin repeat protein. (124 aa)
TNFSF8TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (229 aa)
PTGER4Prostaglandin E2 receptor subtype 4; Belongs to the G-protein coupled receptor 1 family. (475 aa)
LOC112530215Sema domain-containing protein; Belongs to the semaphorin family. (606 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (214 aa)
TCF7HMG box domain-containing protein. (397 aa)
CLCF1Cardiotrophin like cytokine factor 1. (356 aa)
CD4Uncharacterized protein. (487 aa)
SLA2Uncharacterized protein. (279 aa)
ENSGALP00000065981TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (164 aa)
ENSGALP00000066108Uncharacterized protein. (133 aa)
ENSGALP00000066325Uncharacterized protein. (71 aa)
NCK1Cytoplasmic protein. (380 aa)
LOC107049158Ig-like domain-containing protein. (245 aa)
LOC100859414Uncharacterized protein. (193 aa)
EMP2Epithelial membrane protein 2. (167 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
ENSGALP00000067311BEACH domain-containing protein. (161 aa)
TOXThymocyte selection associated high mobility group box. (525 aa)
EXOSC3KH_dom_type_1 domain-containing protein. (288 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CD2Uncharacterized protein. (301 aa)
CCL19C-C motif chemokine. (108 aa)
HELLSHelicase, lymphoid specific. (822 aa)
TSC1Uncharacterized protein. (275 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
ENSGALP00000068753Ig-like domain-containing protein. (159 aa)
ENSGALP00000068805Uncharacterized protein. (165 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
ARMC5Uncharacterized protein. (535 aa)
ENSGALP00000069003Ig-like domain-containing protein. (306 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
LOC100858177Interferon type A1/A2; Has antiviral activities. (193 aa)
TUSC2Uncharacterized protein. (250 aa)
LOC776018Uncharacterized protein. (193 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
FYNTyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2212 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
LOC112529934Ig-like domain-containing protein. (198 aa)
TBX21T-box transcription factor 21. (580 aa)
IFNA3Interferon. (193 aa)
RASSF5Uncharacterized protein. (266 aa)
CD6Uncharacterized protein. (1081 aa)
SH2D6B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...] (598 aa)
LOC100857744Interferon type A1/A2-like. (193 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (727 aa)
LOC100859032Interferon type A1/A2-like. (193 aa)
RIPK3Uncharacterized protein. (424 aa)
NFAM1Uncharacterized protein. (323 aa)
LOC100857947Interferon type A1/A2-like. (193 aa)
IRF9IRF tryptophan pentad repeat domain-containing protein. (472 aa)
LOC107050371Uncharacterized protein. (1015 aa)
DNAJB9J domain-containing protein. (216 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
LOC100857403Interferon type A1/A2-like. (193 aa)
CD3DIg_4 domain-containing protein. (179 aa)
RORAUncharacterized protein. (524 aa)
TNFRSF4Uncharacterized protein. (287 aa)
ENSGALP00000072274TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (126 aa)
ENSGALP00000072433Hist_deacetyl domain-containing protein. (266 aa)
ENSGALP00000072723Ig-like domain-containing protein. (216 aa)
LOC396098Uncharacterized protein. (335 aa)
LOC100858762Uncharacterized protein. (193 aa)
ENSGALP00000073054Ig-like domain-containing protein. (206 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa)
LOC771880-2Ig-like domain-containing protein. (214 aa)
LOC112530959STAT_int domain-containing protein. (392 aa)
RHOHRas homolog family member H. (191 aa)
ENSGALP00000073699Uncharacterized protein. (163 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa)
LEF1HMG box domain-containing protein. (412 aa)
STAT6SH2 domain-containing protein. (183 aa)
TXLNATaxilin alpha. (546 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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