(25 nodes) Vesicle transport along microtubule network (Gallus gallus)

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	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa)
	TRAK2	Trafficking kinesin protein 2. (901 aa)
	BLOC1S4	Biogenesis of lysosomal organelles complex 1 subunit 4. (214 aa)
	HTT	Huntingtin. (3095 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4652 aa)
	HAP1	Uncharacterized protein. (851 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
	AP3M2	AP-3 complex subunit mu-2. (418 aa)
	FYCO1	Uncharacterized protein. (1540 aa)
	FBXW11	Uncharacterized protein. (531 aa)
	NDE1	Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle; Belongs to the nudE family. (342 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1113 aa)
	NDEL1	Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. (358 aa)
	AP3M1	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). (418 aa)
	AP3B2	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1046 aa)
	AP3D1	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (887 aa)
	BLOC1S2	Uncharacterized protein. (141 aa)
	RASGRP1	RAS guanyl releasing protein 1. (480 aa)
	BICDL1	BICD family like cargo adaptor 1. (604 aa)
	EEF1E1	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity); Belongs to the BLOC1S5 family. (221 aa)
	ENSGALP00000065349	Uncharacterized protein. (159 aa)
	BLOC1S6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (163 aa)
	DTNBP1	Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
	TRAK1	Trafficking kinesin protein 1. (1048 aa)
	BLOC1S1	Uncharacterized protein. (125 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3B1	AP3D1	ENSGALP00000049722	ENSGALP00000057250	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	0.988
AP3B1	AP3M1	ENSGALP00000049722	ENSGALP00000054086	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	0.976
AP3B1	AP3M2	ENSGALP00000049722	ENSGALP00000044043	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-2.	0.976
AP3B1	ENSGALP00000065349	ENSGALP00000049722	ENSGALP00000065349	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	Uncharacterized protein.	0.792
AP3B1	SNAPIN	ENSGALP00000049722	ENSGALP00000041040	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.556
AP3B2	AP3D1	ENSGALP00000057238	ENSGALP00000057250	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	0.861
AP3B2	AP3M1	ENSGALP00000057238	ENSGALP00000054086	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	0.848
AP3B2	AP3M2	ENSGALP00000057238	ENSGALP00000044043	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-2.	0.848
AP3B2	ENSGALP00000065349	ENSGALP00000057238	ENSGALP00000065349	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	Uncharacterized protein.	0.792
AP3D1	AP3B1	ENSGALP00000057250	ENSGALP00000049722	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.988
AP3D1	AP3B2	ENSGALP00000057250	ENSGALP00000057238	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.861
AP3D1	AP3M1	ENSGALP00000057250	ENSGALP00000054086	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	0.994
AP3D1	AP3M2	ENSGALP00000057250	ENSGALP00000044043	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	AP-3 complex subunit mu-2.	0.977
AP3D1	ENSGALP00000065349	ENSGALP00000057250	ENSGALP00000065349	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	Uncharacterized protein.	0.921
AP3M1	AP3B1	ENSGALP00000054086	ENSGALP00000049722	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.976
AP3M1	AP3B2	ENSGALP00000054086	ENSGALP00000057238	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.848
AP3M1	AP3D1	ENSGALP00000054086	ENSGALP00000057250	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	0.994
AP3M1	AP3M2	ENSGALP00000054086	ENSGALP00000044043	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	AP-3 complex subunit mu-2.	0.900
AP3M1	ENSGALP00000065349	ENSGALP00000054086	ENSGALP00000065349	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).	Uncharacterized protein.	0.779
AP3M2	AP3B1	ENSGALP00000044043	ENSGALP00000049722	AP-3 complex subunit mu-2.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.976