45 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXOC4	Sec8_exocyst domain-containing protein. (1018 aa)
	STX5	Syntaxin 5; Belongs to the syntaxin family. (344 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (272 aa)
	UNC13B	Unc-13 homolog B. (1574 aa)
	RAB8B	RAB8B, member RAS oncogene family. (201 aa)
	STX10	Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family. (254 aa)
	VPS18	Pep3_Vps18 domain-containing protein. (974 aa)
	RAB3B	RAB3B, member RAS oncogene family. (226 aa)
	STX11	Syntaxin 11. (288 aa)
	EXOC2	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
	RAB3C	RAB3C, member RAS oncogene family. (227 aa)
	CEP83	Centrosomal protein 83. (717 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (863 aa)
	RAB10	Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
	LOC426355	Myb_DNA-bind_5 domain-containing protein. (589 aa)
	RAB8A	Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. (207 aa)
	UNC13A	Uncharacterized protein. (1738 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (407 aa)
	ENSGALP00000074167	Uncharacterized protein. (178 aa)
	STX2	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (288 aa)
	RAB12	RAB12, member RAS oncogene family. (290 aa)
	UNC13C	Uncharacterized protein. (1097 aa)
	SCFD2	Sec1 family domain containing 2; Belongs to the STXBP/unc-18/SEC1 family. (652 aa)
	SYTL2	Synaptotagmin like 2. (863 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
	RABEPK	Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport. (371 aa)
	STX8	t-SNARE coiled-coil homology domain-containing protein. (273 aa)
	YKT6	Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa)
	STXBP1	Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxins, components of the synaptic vesicle fusion machinery. May play a role in determining the specificity of intracellular fusion reactions (By similarity). Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
	STX16	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (326 aa)
	USO1	Uncharacterized protein. (963 aa)
	STX7	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
	LOC422353	Uncharacterized protein. (968 aa)
	RAB10L	Uncharacterized protein. (208 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
	STXBP3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	UNC13C-2	Uncharacterized protein. (411 aa)
	PLEK	Uncharacterized protein. (353 aa)
	STX3	Syntaxin 3; Belongs to the syntaxin family. (462 aa)
	STX17	t-SNARE coiled-coil homology domain-containing protein. (302 aa)
	RAB15	RAB15, member RAS oncogene family. (211 aa)
	STX19	Syntaxin 19; Belongs to the syntaxin family. (291 aa)
	TSNARE1	t-SNARE domain containing 1. (289 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (957 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP83	RAB8A	ENSGALP00000030003	ENSGALP00000041790	Centrosomal protein 83.	Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family.	0.452
CEP83	STX5	ENSGALP00000030003	ENSGALP00000073178	Centrosomal protein 83.	Syntaxin 5; Belongs to the syntaxin family.	0.464
CEP83	USO1	ENSGALP00000030003	ENSGALP00000055676	Centrosomal protein 83.	Uncharacterized protein.	0.507
EXOC2	EXOC4	ENSGALP00000020908	ENSGALP00000071957	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Sec8_exocyst domain-containing protein.	0.999
EXOC2	RAB10	ENSGALP00000020908	ENSGALP00000036002	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...]	0.423
EXOC2	RAB10L	ENSGALP00000020908	ENSGALP00000063237	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Uncharacterized protein.	0.423
EXOC2	RAB15	ENSGALP00000020908	ENSGALP00000067370	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	RAB15, member RAS oncogene family.	0.423
EXOC2	RAB8A	ENSGALP00000020908	ENSGALP00000041790	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family.	0.699
EXOC2	RAB8B	ENSGALP00000020908	ENSGALP00000005505	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	RAB8B, member RAS oncogene family.	0.478
EXOC2	STXBP1	ENSGALP00000020908	ENSGALP00000052373	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxins, components of the synaptic vesicle fusion machinery. May play a role in determining the specificity of intracellular fusion reactions (By similarity). Belongs to the STXBP/unc-18/SEC1 family.	0.505
EXOC2	STXBP3	ENSGALP00000020908	ENSGALP00000065190	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.505
EXOC4	EXOC2	ENSGALP00000071957	ENSGALP00000020908	Sec8_exocyst domain-containing protein.	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.999
EXOC4	RAB10	ENSGALP00000071957	ENSGALP00000036002	Sec8_exocyst domain-containing protein.	Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...]	0.450
EXOC4	RAB10L	ENSGALP00000071957	ENSGALP00000063237	Sec8_exocyst domain-containing protein.	Uncharacterized protein.	0.450
EXOC4	RAB15	ENSGALP00000071957	ENSGALP00000067370	Sec8_exocyst domain-containing protein.	RAB15, member RAS oncogene family.	0.450
EXOC4	RAB3C	ENSGALP00000071957	ENSGALP00000023703	Sec8_exocyst domain-containing protein.	RAB3C, member RAS oncogene family.	0.410
EXOC4	RAB8A	ENSGALP00000071957	ENSGALP00000041790	Sec8_exocyst domain-containing protein.	Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family.	0.737
EXOC4	RAB8B	ENSGALP00000071957	ENSGALP00000005505	Sec8_exocyst domain-containing protein.	RAB8B, member RAS oncogene family.	0.471
EXOC4	STX11	ENSGALP00000071957	ENSGALP00000019058	Sec8_exocyst domain-containing protein.	Syntaxin 11.	0.401
EXOC4	STX3	ENSGALP00000071957	ENSGALP00000066052	Sec8_exocyst domain-containing protein.	Syntaxin 3; Belongs to the syntaxin family.	0.615