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| | ERRFI1 | ERBB receptor feedback inhibitor 1. (465 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (455 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (418 aa) |
| | ZP3 | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, which mediates species- specific sperm binding. Directly binds to sperm. Important for egg fertilization; Belongs to the ZP domain family. ZPC subfamily. (437 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | SPINK5 | Ovoinhibitor; Seems to have at least five active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase. (517 aa) |
| | SPINK7 | Ovomucoid; Serine protease inhibitor. Inhibits trypsin. (210 aa) |
| | DDX5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (603 aa) |
| | GDNF | Glial cell derived neurotrophic factor. (209 aa) |
| | SRC | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa) |
| | AIFM1 | Uncharacterized protein. (689 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | URI1 | URI1 prefoldin like chaperone. (506 aa) |
| | AQP1 | Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa) |
| | GHRHR | G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa) |
| | SSTR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | SCNN1B | Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa) |
| | CPN1 | Uncharacterized protein. (453 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (412 aa) |
| | IRG1L | Uncharacterized protein. (463 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PAQR7 | Progestin and adipoQ receptor family member VII, membrane progestin receptor alpha variant 2. (346 aa) |
| | TRERF1 | Transcriptional regulating factor 1. (1163 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antige [...] (207 aa) |
| | AREG | Amphiregulin. (210 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa) |
| | ESR2 | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. (472 aa) |
| | SSTR3 | Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (402 aa) |
| | RBFOX2 | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (367 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | TMF1 | TATA element modulatory factor 1. (1105 aa) |
| | PCSK1 | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa) |
| | PAM | Peptidylglycine alpha-amidating monooxygenase. (970 aa) |
| | PAQR8 | Progestin and adipoQ receptor family member VIII, membrane progestin receptor beta. (353 aa) |
| | ACOD1 | Uncharacterized protein. (478 aa) |
| | PGR | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (787 aa) |
| | GPR83 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (423 aa) |
| | RWDD1 | RWD domain-containing protein. (240 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) |
| | PDCD7 | Programmed cell death 7. (434 aa) |
| | OVAL | Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa) |
| | TGFB3 | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa) |
| | SSTR2 | Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (371 aa) |
| | BPIFB2 | Protein TENP; May play a role in the developmental transition from cell proliferation to cell differentiation during neurogenesis. (439 aa) |
| | MYOD1 | Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa) |
| | FIBIN | Uncharacterized protein. (206 aa) |
| | TFAP4 | Transcription factor AP-4. (338 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) |
| | ENSGALP00000044025 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa) |
| | LOC100859173 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa) |
| | ADTRP | Androgen dependent TFPI regulating protein. (233 aa) |
| | ESRRB | Estrogen related receptor beta. (454 aa) |
| | EXFABP | Extracellular fatty acid-binding protein; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor; Belongs to the calycin superfamily. Lipocalin family. (178 aa) |
| | SLIT2 | Uncharacterized protein. (1533 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa) |
| | MSTN | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa) |
| | ZFP36L2 | Uncharacterized protein. (489 aa) |
| | AR | Uncharacterized protein. (703 aa) |
| | FBXO32 | Uncharacterized protein. (355 aa) |
| | RXRA | Retinoid X receptor alpha. (467 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa) |
| | BCKDHB | Transket_pyr domain-containing protein. (390 aa) |
| | GDF11 | Growth differentiation factor 11. (368 aa) |
| | TRIP4 | Thyroid hormone receptor interactor 4. (581 aa) |
| | DDX17 | DEAD-box helicase 17; Belongs to the DEAD box helicase family. (655 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2756 aa) |
| | ESRRG | Uncharacterized protein. (519 aa) |
| | UBE2L3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (339 aa) |
| | OVALX | Ovalbumin-related protein X; Belongs to the serpin family. Ov-serpin subfamily. (388 aa) |
| | NR3C1 | Uncharacterized protein. (837 aa) |
| | PPARA | Uncharacterized protein. (468 aa) |
| | NPAS4 | BHLH domain-containing protein. (67 aa) |
| | PADI2 | Peptidylarginine deiminase type II. (663 aa) |
| | FLT3 | Fms related tyrosine kinase 3. (877 aa) |
| | CYP1C1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (212 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) |
| | ZFP36L1 | Zinc finger protein 36 C3H1 type-like 1 protein. (335 aa) |
| | NR3C2 | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). (993 aa) |
| | GPR83L | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (419 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (771 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa) |
| | SOX30 | Uncharacterized protein. (90 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | ABHD2 | Abhydrolase domain containing 2. (425 aa) |
| | REST | Uncharacterized protein. (339 aa) |
| | TRIM63 | Tripartite motif containing 63. (509 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa) |
| | USP8-2 | Rhodanese domain-containing protein. (602 aa) |
| | RXRG | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (469 aa) |
| | SMYD3 | SET and MYND domain containing 3. (487 aa) |
| | MGARP | Mitochondria localized glutamic acid rich protein. (244 aa) |
| | SLIT3 | Uncharacterized protein. (1641 aa) |
| | HSD3B1 | 3Beta_HSD domain-containing protein. (484 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa) |
| | UCN | Urocortin. (100 aa) |
| | DAB2 | DAB adaptor protein 2. (715 aa) |
| | TFPI | Tissue factor pathway inhibitor. (311 aa) |
| | CLDN7 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (407 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa) |
