STRINGSTRING
WISP1 WISP1 ITGB3 ITGB3 HBEGF HBEGF LDLRAP1 LDLRAP1 MMP2 MMP2 MFN2 MFN2 DDR1 DDR1 PIK3CA PIK3CA THBS1 THBS1 FRS2 FRS2 EREG EREG MNAT1 MNAT1 PDGFB PDGFB EDN1 EDN1 IGFBP5 IGFBP5 CX3CL1 CX3CL1 PDGFRB PDGFRB MEF2D MEF2D DDR2 DDR2 RBPMS2 RBPMS2 IL6R IL6R CALCRL CALCRL IL6 IL6 SERPINF2 SERPINF2 MMP9 MMP9 P2RY6 P2RY6 ENSGALP00000073670 ENSGALP00000073670 GJA1 GJA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WISP1Uncharacterized protein. (359 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
HBEGFProheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (144 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
DDR1Uncharacterized protein. (873 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
THBS1Uncharacterized protein. (1175 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
EREGEGF-like domain-containing protein. (153 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
EDN1Endothelin 1. (194 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
CX3CL1SCY domain-containing protein. (496 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa)
MEF2DMADS-box domain-containing protein. (570 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (901 aa)
RBPMS2RNA-binding protein with multiple splicing 2; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells. (200 aa)
IL6RUncharacterized protein. (445 aa)
CALCRLCalcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (514 aa)
MMP9Uncharacterized protein. (713 aa)
P2RY6P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (328 aa)
ENSGALP00000073670Uncharacterized protein. (184 aa)
GJA1Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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