(27 nodes) Axon extension network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLIT2	Uncharacterized protein. (1533 aa)
	ALCAM	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...] (597 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1291 aa)
	LOC771190	Uncharacterized protein. (116 aa)
	SLIT3	Uncharacterized protein. (1641 aa)
	DCLK1	Uncharacterized protein. (740 aa)
	SSNA1	Uncharacterized protein. (114 aa)
	SEMA5A	Semaphorin 5A. (1076 aa)
	SEMA5B	Semaphorin 5B. (1150 aa)
	SRF	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1081 aa)
	EDN2	Endothelin-2. (179 aa)
	AUTS2	Activator of transcription and developmental regulator AUTS2. (1251 aa)
	SEMA7A	Sema domain-containing protein; Belongs to the semaphorin family. (636 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (336 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1001 aa)
	VCL	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
	RYK	Receptor like tyrosine kinase. (481 aa)
	DCX	Doublecortin. (361 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	EDN1	Endothelin 1. (194 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	UBAP1	Ubiquitin associated protein 1. (515 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2425 aa)
	SEMA3F	Sema domain-containing protein; Belongs to the semaphorin family. (838 aa)
	NRP2	Uncharacterized protein. (969 aa)
	LAMB2	Uncharacterized protein. (1802 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf72	ULK1	ENSGALP00000002890	ENSGALP00000052115	C9orf72-SMCR8 complex subunit.	Unc-51 like autophagy activating kinase 1.	0.960
C9orf72	ULK2	ENSGALP00000002890	ENSGALP00000007513	C9orf72-SMCR8 complex subunit.	Unc-51 like autophagy activating kinase 2.	0.428
DCLK1	DCX	ENSGALP00000069677	ENSGALP00000012962	Uncharacterized protein.	Doublecortin.	0.694
DCX	DCLK1	ENSGALP00000012962	ENSGALP00000069677	Doublecortin.	Uncharacterized protein.	0.694
EDN1	EDN2	ENSGALP00000020756	ENSGALP00000000940	Endothelin 1.	Endothelin-2.	0.931
EDN1	EDNRA	ENSGALP00000020756	ENSGALP00000016244	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN2	EDN1	ENSGALP00000000940	ENSGALP00000020756	Endothelin-2.	Endothelin 1.	0.931
EDN2	EDNRA	ENSGALP00000000940	ENSGALP00000016244	Endothelin-2.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.988
EDNRA	EDN1	ENSGALP00000016244	ENSGALP00000020756	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
EDNRA	EDN2	ENSGALP00000016244	ENSGALP00000000940	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin-2.	0.988
NRP2	SEMA3F	ENSGALP00000045108	ENSGALP00000045106	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.992
NRP2	SLIT2	ENSGALP00000045108	ENSGALP00000045198	Uncharacterized protein.	Uncharacterized protein.	0.588
SEMA3F	NRP2	ENSGALP00000045106	ENSGALP00000045108	Sema domain-containing protein; Belongs to the semaphorin family.	Uncharacterized protein.	0.992
SEMA3F	SLIT2	ENSGALP00000045106	ENSGALP00000045198	Sema domain-containing protein; Belongs to the semaphorin family.	Uncharacterized protein.	0.613
SEMA5A	SEMA5B	ENSGALP00000066808	ENSGALP00000054807	Semaphorin 5A.	Semaphorin 5B.	0.661
SEMA5B	SEMA5A	ENSGALP00000054807	ENSGALP00000066808	Semaphorin 5B.	Semaphorin 5A.	0.661
SLIT2	NRP2	ENSGALP00000045198	ENSGALP00000045108	Uncharacterized protein.	Uncharacterized protein.	0.588
SLIT2	SEMA3F	ENSGALP00000045198	ENSGALP00000045106	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.613
SRF	VCL	ENSGALP00000054596	ENSGALP00000008131	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.	Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family.	0.426
ULK1	C9orf72	ENSGALP00000052115	ENSGALP00000002890	Unc-51 like autophagy activating kinase 1.	C9orf72-SMCR8 complex subunit.	0.960