(39 nodes) Oligodendrocyte differentiation network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PLP1	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family. (277 aa)
	SOX13	SRY-box transcription factor 13. (666 aa)
	TSPAN2	Tetraspanin. (222 aa)
	EIF2B1	Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (302 aa)
	VTN	SMB domain-containing protein. (453 aa)
	DLX1	Homeodomain transcription factor DLX1. (255 aa)
	ASPA	Aspartoacylase. (361 aa)
	SOX8	Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
	SHH	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
	WASF3L	WH2 domain-containing protein. (507 aa)
	B4GALT5	Beta-1,4-galactosyltransferase 5. (590 aa)
	NCSTN	Ncstrn_small domain-containing protein. (717 aa)
	DUSP10	Uncharacterized protein. (478 aa)
	EIF2B3	NTP_transferase domain-containing protein. (479 aa)
	EIF2B2	Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (553 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (167 aa)
	NKX6-2	Homeobox domain-containing protein. (364 aa)
	SOX10	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
	B4GALT6	Uncharacterized protein. (382 aa)
	SOX9	Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
	LYN	Tyrosine-protein kinase. (491 aa)
	OLIG2	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
	TPPP	Tubulin polymerization promoting protein. (219 aa)
	EIF2B4	Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (330 aa)
	PRDM8	PR/SET domain 8. (336 aa)
	DLX2	Distal-less homeobox 2. (253 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (711 aa)
	TENM4	Uncharacterized protein. (2766 aa)
	CNP	Uncharacterized protein. (534 aa)
	NKX2-2	Homeobox domain-containing protein. (272 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (2343 aa)
	NKX6-1	NK6 homeobox 1. (272 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
	ENSGALP00000060823	Ig-like domain-containing protein. (511 aa)
	ZNF488	Zinc finger protein 488. (535 aa)
	FA2H	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (373 aa)
	CDK5	Protein kinase domain-containing protein. (522 aa)
	GPR17	G_PROTEIN_RECEP_F1_2 domain-containing protein. (104 aa)
	WASF3	WASP family member 3. (502 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPA	CNP	ENSGALP00000007427	ENSGALP00000053616	Aspartoacylase.	Uncharacterized protein.	0.588
ASPA	EIF2B2	ENSGALP00000007427	ENSGALP00000016737	Aspartoacylase.	Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family.	0.436
ASPA	PLP1	ENSGALP00000007427	ENSGALP00000000160	Aspartoacylase.	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family.	0.500
B4GALT5	B4GALT6	ENSGALP00000013056	ENSGALP00000024401	Beta-1,4-galactosyltransferase 5.	Uncharacterized protein.	0.560
B4GALT6	B4GALT5	ENSGALP00000024401	ENSGALP00000013056	Uncharacterized protein.	Beta-1,4-galactosyltransferase 5.	0.560
B4GALT6	WASF3	ENSGALP00000024401	ENSGALP00000073956	Uncharacterized protein.	WASP family member 3.	0.537
CDK5	NCSTN	ENSGALP00000068854	ENSGALP00000014876	Protein kinase domain-containing protein.	Ncstrn_small domain-containing protein.	0.448
CNP	ASPA	ENSGALP00000053616	ENSGALP00000007427	Uncharacterized protein.	Aspartoacylase.	0.588
CNP	ENSGALP00000060823	ENSGALP00000053616	ENSGALP00000060823	Uncharacterized protein.	Ig-like domain-containing protein.	0.524
CNP	GPR17	ENSGALP00000053616	ENSGALP00000069675	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.488
CNP	OLIG2	ENSGALP00000053616	ENSGALP00000047462	Uncharacterized protein.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.721
CNP	PLP1	ENSGALP00000053616	ENSGALP00000000160	Uncharacterized protein.	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family.	0.718
CNP	SOX10	ENSGALP00000053616	ENSGALP00000020056	Uncharacterized protein.	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.	0.519
DLX1	DLX2	ENSGALP00000006636	ENSGALP00000052409	Homeodomain transcription factor DLX1.	Distal-less homeobox 2.	0.764
DLX1	OLIG2	ENSGALP00000006636	ENSGALP00000047462	Homeodomain transcription factor DLX1.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.516
DLX1	SHH	ENSGALP00000006636	ENSGALP00000010292	Homeodomain transcription factor DLX1.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.557
DLX1	SOX10	ENSGALP00000006636	ENSGALP00000020056	Homeodomain transcription factor DLX1.	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.	0.411
DLX2	DLX1	ENSGALP00000052409	ENSGALP00000006636	Distal-less homeobox 2.	Homeodomain transcription factor DLX1.	0.764
DLX2	OLIG2	ENSGALP00000052409	ENSGALP00000047462	Distal-less homeobox 2.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.711
DLX2	SHH	ENSGALP00000052409	ENSGALP00000010292	Distal-less homeobox 2.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.729