(13 nodes) Positive regulation of oligodendrocyte differentiation network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	OLIG2	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	ASPA	Aspartoacylase. (361 aa)
	NKX6-2	Homeobox domain-containing protein. (364 aa)
	IL34	Interleukin 34. (178 aa)
	GSX2	GS homeobox 2. (263 aa)
	TENM4	Uncharacterized protein. (2766 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (2343 aa)
	TNFRSF1B	Uncharacterized protein. (462 aa)
	NKX6-1	NK6 homeobox 1. (272 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
	ZNF365	Uncharacterized protein. (403 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GSX2	OLIG2	ENSGALP00000049767	ENSGALP00000047462	GS homeobox 2.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.551
IL34	PTPRZ1	ENSGALP00000042039	ENSGALP00000055301	Interleukin 34.	Protein-tyrosine-phosphatase.	0.802
NKX6-2	OLIG2	ENSGALP00000018279	ENSGALP00000047462	Homeobox domain-containing protein.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.758
OLIG2	GSX2	ENSGALP00000047462	ENSGALP00000049767	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	GS homeobox 2.	0.551
OLIG2	NKX6-2	ENSGALP00000047462	ENSGALP00000018279	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	Homeobox domain-containing protein.	0.758
PTPRZ1	IL34	ENSGALP00000055301	ENSGALP00000042039	Protein-tyrosine-phosphatase.	Interleukin 34.	0.802