STRINGSTRING
TRAF6 TRAF6 ELF3 ELF3 CRB1 CRB1 MMP2 MMP2 SRC SRC PLG PLG LRRK1 LRRK1 DLL4 DLL4 JAG1 JAG1 TIE1 TIE1 EDNRA EDNRA SNX10 SNX10 IHH IHH FREM3 FREM3 FGF8 FGF8 TGFB3 TGFB3 IGFBP5 IGFBP5 TNFSF11 TNFSF11 HOXA3 HOXA3 LOC428593 LOC428593 SPP2 SPP2 CTNNB1 CTNNB1 EFNA2 EFNA2 TPP1 TPP1 CHD9 CHD9 DBH DBH ENSGALP00000048186 ENSGALP00000048186 RSPO3 RSPO3 LGR4 LGR4 ATG5 ATG5 IL7 IL7 WNT16 WNT16 BAK1 BAK1 CHD7 CHD7 ACP5 ACP5 EPHA2 EPHA2 EPAS1 EPAS1 BMPR2 BMPR2 ENSGALP00000065224 ENSGALP00000065224 SEMA3C SEMA3C NOX4 NOX4 ACVRL1 ACVRL1 CTHRC1 CTHRC1 ENSGALP00000069955 ENSGALP00000069955 LOC107050371 LOC107050371
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
CRB1Crumbs cell polarity complex component 1. (807 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)
LRRK1Leucine rich repeat kinase 1. (1998 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1140 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
SNX10PX domain-containing protein. (201 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
FREM3Uncharacterized protein. (2495 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
HOXA3Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa)
LOC428593Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (818 aa)
SPP2Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover. (192 aa)
CTNNB1Uncharacterized protein. (781 aa)
EFNA2Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling thro [...] (200 aa)
TPP1Tripeptidyl peptidase 1. (575 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
DBHDopamine beta-hydroxylase. (584 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
RSPO3Uncharacterized protein. (275 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
IL7Interleukin-7. (146 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (507 aa)
BAK1Uncharacterized protein. (216 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (321 aa)
EPHA2EPH receptor A2. (1288 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
ENSGALP00000065224Uncharacterized protein. (381 aa)
SEMA3CSemaphorin-3C; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (751 aa)
NOX4FAD-binding FR-type domain-containing protein. (639 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
LOC107050371Uncharacterized protein. (1015 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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