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| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (213 aa) |
| | EDN2 | Endothelin-2. (179 aa) |
| | TSKU | Tsukushin; Dorsalizing factor involved in the induction of Hensen node. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (369 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (417 aa) |
| | CD34 | CD34 molecule. (385 aa) |
| | BSG | Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development. (388 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (262 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa) |
| | BBS4 | TPR_REGION domain-containing protein. (532 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (807 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | LRRC45 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. (670 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (620 aa) |
| | KLHL10 | BTB domain-containing protein. (584 aa) |
| | SRC | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (528 aa) |
| | PBLD | Uncharacterized protein. (288 aa) |
| | TRPV1 | ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (843 aa) |
| | TRPV3 | ANK_REP_REGION domain-containing protein. (527 aa) |
| | AQP1 | Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa) |
| | TRPM2 | Transient receptor potential cation channel subfamily M member 2. (1508 aa) |
| | HOMER2 | Homer scaffold protein 2. (356 aa) |
| | PASK | PAS domain containing serine/threonine kinase. (1348 aa) |
| | ABCC8 | ATP binding cassette subfamily C member 8. (1595 aa) |
| | USH1C | USH1 protein network component harmonin. (556 aa) |
| | SCNN1B | Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1495 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | RBP4A | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa) |
| | LRRK1 | Leucine rich repeat kinase 1. (1998 aa) |
| | EGR1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa) |
| | DRD2 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa) |
| | IL18 | Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa) |
| | NAPEPLD | Lactamase_B domain-containing protein. (463 aa) |
| | VSIG1 | V-set and immunoglobulin domain-containing protein 1. (335 aa) |
| | VPS54 | VPS54 subunit of GARP complex. (974 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ADRB1 | Adrenoceptor beta 1. (477 aa) |
| | MKKS | Uncharacterized protein. (570 aa) |
| | USH2A | Usherin. (5190 aa) |
| | CLRN1 | Clarin 1. (232 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (386 aa) |
| | OMA1 | OMA1 zinc metallopeptidase. (564 aa) |
| | SNX10 | PX domain-containing protein. (201 aa) |
| | SGIP1 | SH3 domain GRB2 like endophilin interacting protein 1. (783 aa) |
| | ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) |
| | IHH | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa) |
| | HCRT | Uncharacterized protein. (148 aa) |
| | IQCB1 | IQ motif containing B1. (597 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | STRAP | Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins are trapped in an inactive complex. The SMN complex triggers the assembly of core snRNPs and their transport to the nucleus. ST [...] (350 aa) |
| | ZNF830 | Zinc finger protein 830. (532 aa) |
| | FH | Uncharacterized protein. (507 aa) |
| | IL20RB | Interleukin 20 receptor subunit beta. (312 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (560 aa) |
| | CYTL1 | Cytokine like 1. (132 aa) |
| | ILDR2 | Immunoglobulin like domain containing receptor 2. (628 aa) |
| | WFS1 | Wolframin ER transmembrane glycoprotein. (874 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (394 aa) |
| | MRAP2 | Uncharacterized protein. (206 aa) |
| | LCA5 | Lebercilin LCA5. (683 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | TFF2 | Trefoil factor 2. (127 aa) |
| | IL17A | Uncharacterized protein. (169 aa) |
| | ADRB3 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa) |
| | TSTD1 | Uncharacterized protein. (358 aa) |
| | NR1D2 | Uncharacterized protein. (587 aa) |
| | NMU | Neuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | LEPR | Uncharacterized protein. (1148 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (351 aa) |
| | BTBD9 | BTB domain-containing protein. (647 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | CRB2 | Uncharacterized protein. (1469 aa) |
| | MBL2 | Mannose-binding protein; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. (254 aa) |
| | TNFSF11 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (484 aa) |
| | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. (191 aa) |
| | NXNL2 | Nucleoredoxin like 2. (156 aa) |
| | MC3R | Melanocortin 3 receptor. (325 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | NANOS1 | Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (254 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1771 aa) |
| | HAS2 | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity); Belongs to the NodC/HAS family. (552 aa) |
| | USH1G | USH1 protein network component sans. (457 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | SLC40A1 | Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (581 aa) |
| | CLN8 | TLC domain-containing protein. (285 aa) |
| | CROCC | Uncharacterized protein. (971 aa) |
| | TPP1 | Tripeptidyl peptidase 1. (575 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. (612 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (579 aa) |
| | IRX3 | Iroquois homeobox 3. (445 aa) |
| | DBH | Dopamine beta-hydroxylase. (584 aa) |
| | NXNL1 | Nucleoredoxin like 1. (205 aa) |
| | ENSGALP00000047771 | Uncharacterized protein. (240 aa) |
| | MLXIPL | BHLH domain-containing protein. (895 aa) |
| | PIBPPDD4L | Phosphoinositide phospholipase C. (1139 aa) |
| | PRDM14 | PR/SET domain 14. (514 aa) |
| | NPHP4 | Nephrocystin 4. (1386 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa) |
| | EXT2 | Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (717 aa) |
| | ADRB2 | Adrenoceptor beta 2. (402 aa) |
| | SMO | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa) |
| | TJP2 | Uncharacterized protein; Belongs to the MAGUK family. (1373 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (941 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) |
| | MUC6 | Mucin-6; Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6. (1173 aa) |
| | DRAM2 | DNA damage regulated autophagy modulator 2. (266 aa) |
| | NOV | CTCK domain-containing protein. (360 aa) |
| | ENSGALP00000051627 | ANK_REP_REGION domain-containing protein. (323 aa) |
| | CTSH | Uncharacterized protein; Belongs to the peptidase C1 family. (403 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (290 aa) |
| | IL7 | Interleukin-7. (146 aa) |
| | AKAP11 | A-kinase anchoring protein 11. (1957 aa) |
| | SQSTM1 | Sequestosome 1. (453 aa) |
| | PPARGC1A | RRM domain-containing protein. (795 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | MET | Uncharacterized protein. (1382 aa) |
| | BBS10 | Uncharacterized protein. (317 aa) |
| | SCNN1G | Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa) |
| | HOMER1 | Homer scaffold protein 1. (358 aa) |
| | GIGYF2 | GYF domain-containing protein. (1278 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (321 aa) |
| | PRCP | Prolylcarboxypeptidase. (483 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (721 aa) |
| | SASH3 | Uncharacterized protein. (382 aa) |
| | EPAS1 | Endothelial PAS domain protein 1. (867 aa) |
| | PRLH | Uncharacterized protein. (87 aa) |
| | STMN1 | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity). (172 aa) |
| | TMEM79 | Transmembrane protein 79. (435 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (656 aa) |
| | MKS1 | MKS transition zone complex subunit 1. (562 aa) |
| | CSF1 | Uncharacterized protein. (493 aa) |
| | ENSGALP00000065224 | Uncharacterized protein. (381 aa) |
| | MTF1 | Uncharacterized protein. (729 aa) |
| | BBS12 | Bardet-Biedl syndrome 12. (777 aa) |
| | ANKRD31 | Uncharacterized protein. (1555 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) |
| | NOX4 | FAD-binding FR-type domain-containing protein. (639 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (230 aa) |
| | INAVA | Innate immunity activator. (565 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa) |
| | USP45 | Ubiquitin carboxyl-terminal hydrolase. (815 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (373 aa) |
| | RP1L1 | Uncharacterized protein. (2325 aa) |
| | TJP3 | Tight junction protein 3; Belongs to the MAGUK family. (1069 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (678 aa) |
| | SPATA7 | Spermatogenesis associated 7. (565 aa) |
| | PM20D1 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration; Belongs to the peptidase M20A family. (567 aa) |
| | CCDC66 | Coiled-coil domain containing 66. (995 aa) |
| | ADGRV1 | Uncharacterized protein. (4788 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (137 aa) |
| | CRACD | KIAA1211. (1561 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | WHRN | Whirlin. (926 aa) |
| | ENSGALP00000071692 | Uncharacterized protein. (105 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2707 aa) |
| | AQP4 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (417 aa) |
| | ENSGALP00000073754 | Uncharacterized protein. (146 aa) |
| | CLDN7 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (407 aa) |
| | ENSGALP00000073923 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (324 aa) |
| | ADGRF5 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1342 aa) |
| | SLC35D3 | Solute carrier family 35 member D3. (424 aa) |
