STRINGSTRING
XKR8 XKR8 BTN1 BTN1 CASP3 CASP3 GATA3 GATA3 C5H15orf41 C5H15orf41 LOC112530162 LOC112530162 RC3H1 RC3H1 DOCK10 DOCK10 BAK1 BAK1 CEBPG CEBPG UBAP2 UBAP2 SRF SRF FLT3 FLT3 MERTK MERTK IL7 IL7 SOS1 SOS1 KIT KIT CCR4 CCR4 SART3 SART3 ATPIF1 ATPIF1 LGR4 LGR4 ADGRG1 ADGRG1 SMO SMO NKX2-6 NKX2-6 NKX2-3 NKX2-3 CCR7 CCR7 SLC25A38 SLC25A38 PRDM14 PRDM14 CDH15 CDH15 LYN LYN TNFAIP3 TNFAIP3 CCN3 CCN3 SP3 SP3 ALAS1 ALAS1 SLC40A1 SLC40A1 PTH PTH ENSGALP00000044025 ENSGALP00000044025 CDK5RAP3 CDK5RAP3 SLC46A2 SLC46A2 TNFRSF13B TNFRSF13B ACE ACE SOX9 SOX9 PLA2G10 PLA2G10 ANXA1 ANXA1 WDR48 WDR48 PLA2G10L PLA2G10L ARHGEF5 ARHGEF5 GPR183 GPR183 TNFSF13B TNFSF13B PKNOX1 PKNOX1 UFL1 UFL1 CDH2 CDH2 TRAF3IP2 TRAF3IP2 LYAR LYAR FSTL1 FSTL1 GCNT4 GCNT4 PTPN2 PTPN2 MYCT1 MYCT1 IL7R IL7R MAEA MAEA IL20RB IL20RB FH FH BCL2 BCL2 SERPINB10B SERPINB10B FANCC FANCC MB MB SOS2 SOS2 RCOR1 RCOR1 ABCB10 ABCB10 PPP2R3C PPP2R3C NCSTN NCSTN VPS54 VPS54 GPAM GPAM NAPEPLD NAPEPLD KMT2E KMT2E SLC37A4 SLC37A4 FADD FADD BCL6 BCL6 NCAPG2 NCAPG2 CAMLG CAMLG SHH SHH SCNN1B SCNN1B LOC407092 LOC407092 NLE1 NLE1 SH2B3 SH2B3 CARD11 CARD11 CCNB1 CCNB1 P2RX7 P2RX7 FOXN1 FOXN1 KLHL10 KLHL10 LGALS2 LGALS2 LRRC45 LRRC45 HSPA9 HSPA9 CARD9 CARD9 ST6GALNAC1 ST6GALNAC1 MED1 MED1 SPNS2 SPNS2 RC3H2 RC3H2 ARID4A ARID4A ENSGALP00000070609 ENSGALP00000070609 BCL2L11 BCL2L11 RB1 RB1 KCNQ1 KCNQ1 LOC112530285 LOC112530285 ENSGALP00000072274 ENSGALP00000072274 ADGRF5 ADGRF5 JAK2 JAK2 CASP14 CASP14 SKIL SKIL GIGYF2 GIGYF2 UBAP2L UBAP2L CX3CR1 CX3CR1 SASH3 SASH3 UBA5 UBA5 EPAS1 EPAS1 HOXB6 HOXB6 LRRC19 LRRC19 LPCAT3 LPCAT3 GPI GPI POLB POLB SERPINB10A SERPINB10A TMEM14C TMEM14C CSF1 CSF1 JAM3 JAM3 DMTN DMTN ENSGALP00000065981 ENSGALP00000065981 ADAR ADAR IL6 IL6 ZFPM1 ZFPM1 GLIS2 GLIS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XKR8XK-related protein. (414 aa)
BTN1B30.2/SPRY domain-containing protein. (424 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
C5H15orf41Protein C15orf41 homolog; May play a role in erythroid cell differentiation. (315 aa)
LOC112530162Uncharacterized protein. (159 aa)
RC3H1Ring finger and CCCH-type domains 1. (1114 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2212 aa)
BAK1Uncharacterized protein. (216 aa)
CEBPGLeucine zipper transcription factor. (150 aa)
UBAP2Uncharacterized protein. (862 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
FLT3Fms related tyrosine kinase 3. (877 aa)
MERTKUncharacterized protein. (990 aa)
IL7Interleukin-7. (146 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (943 aa)
ATPIF1Uncharacterized protein. (92 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
NKX2-6Homeobox domain-containing protein. (193 aa)
NKX2-3Homeobox domain-containing protein. (328 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (288 aa)
PRDM14PR/SET domain 14. (514 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
LYNTyrosine-protein kinase. (491 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
CCN3CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
ALAS15-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (635 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (581 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
CDK5RAP3Uncharacterized protein. (619 aa)
SLC46A2Solute carrier family 46 member 2. (453 aa)
TNFRSF13BTNFR-Cys domain-containing protein. (259 aa)
ACEAngiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
PLA2G10Phospholipase A(2). (155 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (678 aa)
PLA2G10LPhospholipase A(2). (158 aa)
ARHGEF5Uncharacterized protein. (1733 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa)
TNFSF13BTNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
UFL1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
TRAF3IP2SEFIR domain-containing protein. (532 aa)
LYARLy1 antibody reactive. (364 aa)
FSTL1Uncharacterized protein. (315 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (455 aa)
PTPN2Uncharacterized protein. (597 aa)
MYCT1MYC target 1. (192 aa)
IL7RInterleukin-7 receptor alpha chain. (460 aa)
MAEAE3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] (396 aa)
IL20RBInterleukin 20 receptor subunit beta. (312 aa)
FHUncharacterized protein. (507 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
SERPINB10BHeterochromatin-associated protein MENT; DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases. Belongs to the serpin family. Ov-serpin subfamily. (410 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa)
RCOR1REST corepressor 1. (449 aa)
ABCB10ATP binding cassette subfamily B member 10. (523 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (461 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
VPS54VPS54 subunit of GARP complex. (974 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
NAPEPLDLactamase_B domain-containing protein. (463 aa)
KMT2ELysine methyltransferase 2E. (1814 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
FADDFas associated via death domain. (195 aa)
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1144 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (289 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa)
LOC407092UBA domain-containing protein. (1109 aa)
NLE1Notchless homolog 1. (482 aa)
SH2B3SH2B adaptor protein 3. (539 aa)
CARD11Uncharacterized protein. (1170 aa)
CCNB1G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
FOXN1Forkhead box N1. (636 aa)
KLHL10BTB domain-containing protein. (584 aa)
LGALS2Galectin. (131 aa)
LRRC45Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. (670 aa)
HSPA9Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. (675 aa)
CARD9Caspase recruitment domain family member 9. (574 aa)
ST6GALNAC1Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1. (566 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
SPNS2Sphingolipid transporter 2. (510 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
ARID4AARID domain-containing protein. (1252 aa)
ENSGALP00000070609Uncharacterized protein. (335 aa)
BCL2L11BCL2 like 11. (179 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
LOC112530285SAP domain-containing protein. (172 aa)
ENSGALP00000072274TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (126 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1342 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
CASP14Caspase-17/a; Belongs to the peptidase C14A family. (266 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (690 aa)
GIGYF2GYF domain-containing protein. (1278 aa)
UBAP2LUbiquitin associated protein 2 like. (1125 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
SASH3Uncharacterized protein. (382 aa)
UBA5Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. (394 aa)
EPAS1Endothelial PAS domain protein 1. (867 aa)
HOXB6Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (222 aa)
LRRC19Uncharacterized protein. (176 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (501 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
SERPINB10ASERPIN domain-containing protein; Belongs to the serpin family. (423 aa)
TMEM14CUncharacterized protein. (107 aa)
CSF1Uncharacterized protein. (493 aa)
JAM3Junctional adhesion molecule 3. (458 aa)
DMTNAbLIM_anchor domain-containing protein. (687 aa)
ENSGALP00000065981TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (164 aa)
ADARRNA-specific Adenosine deaminase Transcript variant M. (1153 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1079 aa)
GLIS2Uncharacterized protein. (649 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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