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| | PKNOX1 | PBX/knotted 1 homeobox 1. (436 aa) |
| | DSCAM | Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (2034 aa) |
| | NECTIN3 | Nectin cell adhesion molecule 3. (559 aa) |
| | RORB | Nuclear orphan receptor ROR-beta. (459 aa) |
| | TBC1D32 | TBC1 domain family member 32. (1301 aa) |
| | C1H12ORF57 | Uncharacterized protein. (126 aa) |
| | E1C1Y1_CHICK | Uncharacterized protein. (351 aa) |
| | AHI1 | Abelson helper integration site 1. (1242 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) |
| | PBX1 | PBX1A. (430 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | THL | BH4_AAA_HYDROXYL_2 domain-containing protein. (443 aa) |
| | AGTPBP1 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1225 aa) |
| | TDRD7 | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis. (1095 aa) |
| | RAB3GAP1 | RAB3 GTPase activating protein catalytic subunit 1. (1014 aa) |
| | AMHR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa) |
| | BBS7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (716 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa) |
| | CRYBA2 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens. (196 aa) |
| | IHH | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa) |
| | CEP290 | Uncharacterized protein. (553 aa) |
| | TTC8 | Tetratricopeptide repeat domain 8. (567 aa) |
| | FRS2 | IRS-type PTB domain-containing protein. (508 aa) |
| | MDM1 | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. (738 aa) |
| | PRPH2 | Peripherin-2; May be involved in the morphogenesis of retina outer segment disks and the development and maintenance of the retina ultrastructure. (354 aa) |
| | RD3 | Retinal degeneration 3, GUCY2D regulator. (350 aa) |
| | PROX1 | Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa) |
| | IFT140 | WD_REPEATS_REGION domain-containing protein. (1453 aa) |
| | VAX1 | Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa) |
| | TSPAN12 | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] (305 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa) |
| | NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) |
| | WDPCP | WD repeat containing planar cell polarity effector. (807 aa) |
| | DZANK1 | ANK_REP_REGION domain-containing protein. (767 aa) |
| | LHX5 | LIM homeobox protein 5. (402 aa) |
| | DCX | Doublecortin. (361 aa) |
| | CRYAB | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. (174 aa) |
| | DRD2 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa) |
| | DSCAML1 | Down syndrome cell adhesion molecule-like protein 1 homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. (2042 aa) |
| | RBP4A | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa) |
| | PDE6C | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. (862 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | TBC1D20 | TBC1 domain family member 20. (394 aa) |
| | USH1C | USH1 protein network component harmonin. (556 aa) |
| | CRYGN | Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (183 aa) |
| | BHLHE23 | BHLH transcription factor neuroAB. (220 aa) |
| | LHX1 | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa) |
| | WNT9A | Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in embryonic chondrocyte maturation and in embryonic bone mineralization (By similarity). (503 aa) |
| | SOX8 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa) |
| | AQP1 | Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa) |
| | B9D1 | B9 domain containing 1. (196 aa) |
| | FOXN4 | Forkhead box N4. (513 aa) |
| | FBN1 | Fibrillin 1. (2861 aa) |
| | C1QA | Complement C1q A chain. (243 aa) |
| | EPHB2 | Ephrin type-B receptor 2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses (B [...] (995 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (377 aa) |
| | MFN2 | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa) |
| | CRYBA1 | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family. (215 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (528 aa) |
| | FASLG | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa) |
| | LOC427439 | Nipped-B protein. (2783 aa) |
| | SCAPER | S-phase cyclin A associated protein in the ER. (1365 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (484 aa) |
| | ACHE | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (767 aa) |
| | FAT1 | FAT atypical cadherin 1. (4645 aa) |
| | PRDM1 | PR/SET domain 1. (789 aa) |
| | TULP3 | Tubby-like protein; Belongs to the TUB family. (465 aa) |
| | HPS1 | Uncharacterized protein. (788 aa) |
| | ENSGALP00000072012 | Uncharacterized protein. (173 aa) |
| | RDH10 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (446 aa) |
| | NF2L | FERM domain-containing protein. (648 aa) |
| | LOC107050371 | Uncharacterized protein. (1015 aa) |
| | MFAP5 | Microfibril associated protein 5. (154 aa) |
| | ENSGALP00000069955 | Uncharacterized protein. (496 aa) |
| | CRYBB1 | Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens. (238 aa) |
| | RPGRIP1L | RPGRIP1 like. (1273 aa) |
| | BCHE | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (603 aa) |
| | GATA3 | GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa) |
| | RP1L1 | Uncharacterized protein. (2325 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa) |
| | MTERF4 | Uncharacterized protein. (131 aa) |
| | MEIS1 | Homeobox domain-containing protein. (465 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa) |
| | CABP4 | Calcium binding protein 4. (173 aa) |
| | ATOH7 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3. (151 aa) |
| | MEGF11 | Multiple EGF like domains 11. (1084 aa) |
| | CRYBG3 | Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (237 aa) |
| | ENSGALP00000065224 | Uncharacterized protein. (381 aa) |
| | FKBP8 | Peptidylprolyl isomerase. (686 aa) |
| | SDK2 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. (2205 aa) |
| | KERA | Keratocan; Plays an important role in generating and maintaining a transparent matrix within the corneal stroma. (353 aa) |
| | TTLL5 | Uncharacterized protein. (1338 aa) |
| | PRSS56 | Peptidase S1 domain-containing protein. (483 aa) |
| | PBX4 | PBX homeobox 4. (480 aa) |
| | FABP7 | Fatty acid-binding protein, brain; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | RAB18 | Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). (206 aa) |
| | CRYBA4 | Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens. (196 aa) |
| | SDK1 | Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions ; Belongs to the sidekick family. (2275 aa) |
| | SLITRK6 | SLIT and NTRK like family member 6. (840 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa) |
| | RPL24 | TRASH domain-containing protein. (156 aa) |
| | MAB21L1 | Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity). (359 aa) |
| | TMEM231 | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (320 aa) |
| | WDR19 | WD_REPEATS_REGION domain-containing protein. (470 aa) |
| | MEIS2 | Homeoprotein Meis2a.2. (394 aa) |
| | SIX3 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa) |
| | ZHX2 | Zinc fingers and homeoboxes 2. (830 aa) |
| | NECTIN1 | Nectin cell adhesion molecule 1. (523 aa) |
| | EPHA2 | EPH receptor A2. (1288 aa) |
| | WNT3A | Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa) |
| | ENSGALP00000057297 | Uncharacterized protein. (745 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (884 aa) |
| | CHD7 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa) |
| | IGFN1 | Uncharacterized protein. (2363 aa) |
| | SLC17A8 | MFS domain-containing protein. (587 aa) |
| | SLC17A6 | MFS domain-containing protein. (585 aa) |
| | SKIL | c-SKI_SMAD_bind domain-containing protein. (690 aa) |
| | BAK1 | Uncharacterized protein. (216 aa) |
| | ALDH1A3 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa) |
| | CYP1C1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa) |
| | NEUROD4 | Neurogenic differentiation factor 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). (330 aa) |
| | TULP1 | Tubby-like protein; Belongs to the TUB family. (358 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | CRYAA | Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens; Belongs to the small heat shock protein (HSP20) family. (173 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | MERTK | Uncharacterized protein. (990 aa) |
| | FABP3 | Heart fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa) |
| | FAT3 | Uncharacterized protein. (4598 aa) |
| | PWWP2A | PWWP domain containing 2A. (787 aa) |
| | LOC427025 | Nipped-B protein. (2769 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (807 aa) |
| | OPN4 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (528 aa) |
| | BBS4 | TPR_REGION domain-containing protein. (532 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa) |
| | STRA6 | Uncharacterized protein. (671 aa) |
| | BSG | Basigin; Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development. (388 aa) |
| | CLIC4 | Chloride intracellular channel 4. (253 aa) |
| | PBX3 | Homeobox domain-containing protein. (433 aa) |
| | TMEM132E | Transmembrane protein 132E. (1053 aa) |
| | FREM2 | FRAS1 related extracellular matrix 2. (3168 aa) |
| | CRYBG2 | Crystallin beta-gamma domain containing 2; Belongs to the beta/gamma-crystallin family. (1493 aa) |
| | TH | Tyrosine hydroxylase. (491 aa) |
| | ZDHHC16 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (375 aa) |
| | RAB18L | Uncharacterized protein. (204 aa) |
| | SOX1 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa) |
| | NEUROD2 | Neurogenic differentiation factor. (356 aa) |
| | MIP | Lens fiber major intrinsic protein; Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa) |
| | TUB | Tubby-like protein; Belongs to the TUB family. (479 aa) |
| | AQP2 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (275 aa) |
| | AQP5 | Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa) |
| | PHACTR4 | Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the RHO/ROCK pathway (By similarity). (199 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa) |
| | ARHGAP35 | Rho GTPase activating protein 35. (1613 aa) |
| | NPHP4 | Nephrocystin 4. (1386 aa) |
| | ENSGALP00000048186 | Uncharacterized protein. (528 aa) |
| | LAMB2 | Uncharacterized protein. (1802 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2820 aa) |
| | WNT7B | Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). (353 aa) |
| | PITX2 | Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa) |
| | MFAP2 | Microfibril associated protein 2. (187 aa) |
| | POU4F1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa) |
| | SP3 | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa) |
| | CLN8 | TLC domain-containing protein. (285 aa) |
| | NDP | CTCK domain-containing protein. (133 aa) |
| | OPN4-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (543 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | PYGO2 | Pygopus family PHD finger 2. (651 aa) |
| | PFDN5 | Prefoldin subunit 5. (155 aa) |
| | WNT2B | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa) |
| | SH3PXD2B | SH3 and PX domains 2B. (876 aa) |
| | ENSGALP00000044025 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa) |
| | RAX | Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (317 aa) |
| | FJX1 | Four jointed box 1. (384 aa) |
| | NAGLU | N-acetyl-alpha-glucosaminidase. (751 aa) |
| | PDGFRB | Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa) |
| | GPM6A | Neuronal proteolipid GPM6A. (278 aa) |
| | ATF6 | Activating transcription factor 6. (671 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa) |
| | MYF5 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) |
| | CNTF | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa) |
| | PTF1A | Pancreas associated transcription factor 1a. (275 aa) |
| | THY1 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa) |
| | BFSP1 | Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments. (657 aa) |
| | CRB2 | Uncharacterized protein. (1469 aa) |
| | CRYBB3 | Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens. (211 aa) |
| | CRYBB2 | Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens. (205 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | ATF4 | ATF4. (354 aa) |
| | BMPR1B | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptiona (By similarity). Positively regulates chondrocyte differentiation. (502 aa) |
| | PHOX2B | Paired like homeobox 2B. (292 aa) |
| | SIX6 | Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa) |
| | LAMA1 | Uncharacterized protein. (3091 aa) |
| | GJA8 | Gap junction alpha-8 protein; Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore ; Belongs to the connexin family. Alpha-type (group II) subfamily. (400 aa) |
| | NHS | NHS actin remodeling regulator. (1466 aa) |
| | FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) |
| | ANGPTL7 | Angiopoietin like 7. (347 aa) |
| | NF2 | FERM domain-containing protein. (595 aa) |
| | CRYGS | Gamma S-crystallin; Belongs to the beta/gamma-crystallin family. (178 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (351 aa) |
| | PDE6B | Phosphodiesterase. (836 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa) |
| | OPN5L2 | Opsin 5-like 2; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (348 aa) |
| | GAS1 | Growth arrest specific 1. (159 aa) |
| | FZD4 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa) |
| | OPN5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | RS1 | F5/8 type C domain-containing protein. (224 aa) |
| | ZNF513 | Zinc finger protein 513. (290 aa) |
| | IFT172 | Intraflagellar transport 172. (1749 aa) |
