STRINGSTRING
LGR5 LGR5 EREG EREG AREG AREG CAV3 CAV3 CEBPB CEBPB EHF EHF DRD2 DRD2 PROK2 PROK2 APOA1 APOA1 A4GNT A4GNT XBP1 XBP1 SCARB1 SCARB1 HNF1B HNF1B PIK3CB PIK3CB NKX2-5 NKX2-5 MED1 MED1 KDF1 KDF1 LOXL2 LOXL2 SAV1 SAV1 TRIM24 TRIM24 ST8SIA1 ST8SIA1 KDR KDR IFT57 IFT57 ITGB1BP1 ITGB1BP1 IFT172 IFT172 C26H6orf89 C26H6orf89 ERD2L ERD2L PHOX2B PHOX2B IGFBP5 IGFBP5 SOX9 SOX9 TGFA TGFA TNFSF11 TNFSF11 NKX2-8 NKX2-8 FGF7 FGF7 CAV1 CAV1 ENSGALP00000044025 ENSGALP00000044025 IFT52 IFT52 MTSS1 MTSS1 CYP7B1 CYP7B1 AR AR NOX5 NOX5 CCN3 CCN3 FLCN FLCN BTRC BTRC SMO SMO HGF HGF LGR4 LGR4 WDR77 WDR77 BMPER BMPER BCL2L1 BCL2L1 TGFBR1 TGFBR1 PDX1 PDX1 WNT16 WNT16 PRKX PRKX BAK1 BAK1 ESRP2 ESRP2 SERPINF1 SERPINF1 EPHA2 EPHA2 HLX HLX BMPR2 BMPR2 TP63 TP63 CAV2 CAV2 NRARP NRARP NCSTN NCSTN SDR16C5 SDR16C5 PPARD PPARD TEK TEK RB1 RB1 IGFBP4 IGFBP4 PROK1 PROK1 PSEN1 PSEN1 FGL1 FGL1 IFT74 IFT74 IL6 IL6 EFNB2 EFNB2 LOXL3 LOXL3 IFT80 IFT80
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (909 aa)
EREGEGF-like domain-containing protein. (153 aa)
AREGAmphiregulin. (210 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CEBPBCCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa)
EHFUncharacterized protein. (298 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
PROK2Prokineticin 2. (109 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (388 aa)
XBP1BZIP domain-containing protein. (372 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
HNF1BHNF1 homeobox B. (531 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
NKX2-5Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
KDF1Keratinocyte differentiation factor 1. (417 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (773 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
TRIM24Tripartite motif containing 24. (1165 aa)
ST8SIA1CMP-NeuAc:GM3 sialyltransferase; Belongs to the glycosyltransferase 29 family. (342 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
IFT57Intraflagellar transport 57. (532 aa)
ITGB1BP1PID domain-containing protein. (208 aa)
IFT172Intraflagellar transport 172. (1749 aa)
C26H6orf89Uncharacterized protein. (328 aa)
ERD2LUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
PHOX2BPaired like homeobox 2B. (292 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
TGFAEGF-like domain-containing protein. (156 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
NKX2-8NK2 homeobox 8. (203 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
IFT52Uncharacterized protein. (489 aa)
MTSS1Uncharacterized protein. (701 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa)
ARUncharacterized protein. (703 aa)
NOX5Uncharacterized protein. (771 aa)
CCN3CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
WDR77WD_REPEATS_REGION domain-containing protein. (359 aa)
BMPERCrossveinless-2. (678 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PDX1Homeobox domain-containing protein. (259 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (507 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (366 aa)
BAK1Uncharacterized protein. (216 aa)
ESRP2Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity); Belongs to the ESRP family. (728 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
EPHA2EPH receptor A2. (1288 aa)
HLXH2.0 like homeobox. (431 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
NRARPNOTCH regulated ankyrin repeat protein. (124 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
SDR16C5Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (476 aa)
PPARDUncharacterized protein. (545 aa)
TEKTEK receptor tyrosine kinase. (1128 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
IGFBP4IGFBP N-terminal domain-containing protein. (284 aa)
PROK1Prokineticin 1. (99 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
FGL1Fibrinogen C-terminal domain-containing protein. (313 aa)
IFT74Intraflagellar transport 74. (591 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
EFNB2Ephrin-B2; Belongs to the ephrin family. (333 aa)
LOXL3Lysyl oxidase like 3. (755 aa)
IFT80Intraflagellar transport 80. (790 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (16%) [HD]