STRINGSTRING
TRH TRH NR0B2 NR0B2 PARD6A PARD6A C1QTNF12 C1QTNF12 AACS AACS P2RX7 P2RX7 GPER1 GPER1 PSMD9 PSMD9 TRPM2 TRPM2 RBP4A RBP4A ACSL4 ACSL4 GHRL GHRL SRI SRI FGG FGG PPID PPID TMED10 TMED10 VEGFC VEGFC WLS WLS TGFBR2 TGFBR2 NR1H4 NR1H4 PLA2G6 PLA2G6 EZR EZR PCSK1 PCSK1 RFX6 RFX6 MPC2 MPC2 BLK BLK TGFB2 TGFB2 GCG GCG LOC422308 LOC422308 ARF6 ARF6 GOLPH3 GOLPH3 GLUD2 GLUD2 LRRC8A LRRC8A MYRIP MYRIP EXOC1 EXOC1 HMMR HMMR CFTR CFTR ATP13A2 ATP13A2 C2CD2L C2CD2L GOLPH3L GOLPH3L PDX1 PDX1 ADCY8 ADCY8 LOC107049174 LOC107049174 MYOM1 MYOM1 FRMD4A FRMD4A CAPN10 CAPN10 SIRT6 SIRT6 ENSGALP00000068436 ENSGALP00000068436 IER3IP1 IER3IP1 TM7SF3 TM7SF3 DNM1L DNM1L APBB3 APBB3 GPLD1 GPLD1 SYTL4 SYTL4 RPH3AL RPH3AL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
NR0B2NR LBD domain-containing protein. (262 aa)
PARD6APar-6 family cell polarity regulator alpha. (357 aa)
C1QTNF12C1q and TNF related 12. (320 aa)
AACSAcetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). (743 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
PSMD9PDZ domain-containing protein. (207 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
RBP4ARetinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
GHRLPreproghrelin. (116 aa)
SRIUncharacterized protein. (297 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
TMED10GOLD domain-containing protein. (219 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
WLSProtein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
NR1H4Farnesoid X receptor. (473 aa)
PLA2G6Uncharacterized protein. (796 aa)
EZREzrin. (585 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
RFX6Regulatory factor X6. (916 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (133 aa)
BLKTyrosine-protein kinase. (526 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
LOC422308Sec3-PIP2_bind domain-containing protein. (860 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
GOLPH3Uncharacterized protein. (294 aa)
GLUD2Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
MYRIPRab_eff_C domain-containing protein. (666 aa)
EXOC1Exocyst complex component 1. (920 aa)
HMMRHyaluronan mediated motility receptor. (728 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1180 aa)
C2CD2LSMP_C2CD2L domain-containing protein. (707 aa)
GOLPH3LGolgi phosphoprotein 3 like. (279 aa)
PDX1Homeobox domain-containing protein. (259 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
LOC107049174Uncharacterized protein. (293 aa)
MYOM1Uncharacterized protein. (1671 aa)
FRMD4AFERM domain containing 4A. (698 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
ENSGALP00000068436Uncharacterized protein. (116 aa)
IER3IP1Uncharacterized protein. (177 aa)
TM7SF3Transmembrane 7 superfamily member 3. (563 aa)
DNM1LUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
APBB3Amyloid beta precursor protein binding family B member 3. (504 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
SYTL4Synaptotagmin like 4. (690 aa)
RPH3ALUncharacterized protein. (295 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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