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SYTL4 SYTL4 NR0B2 NR0B2 C1QTNF12 C1QTNF12 C26H6ORF125 C26H6ORF125 AACS AACS GPER1 GPER1 PSMD9 PSMD9 SYT9 SYT9 TRPM2 TRPM2 ABCC8 ABCC8 RBP4A RBP4A FAM3D FAM3D ACSL4 ACSL4 GHRL GHRL TRH TRH KLF7 KLF7 SRI SRI NR1H4 NR1H4 PLA2G6 PLA2G6 IGF1 IGF1 RFX6 RFX6 MPC2 MPC2 BLK BLK MTNR1B MTNR1B KCNJ11 KCNJ11 GCG GCG KCNB1 KCNB1 BIRC5 BIRC5 PIM3 PIM3 NDUFAF2 NDUFAF2 RPH3AL RPH3AL INHBB INHBB GLUD2 GLUD2 LRRC8A LRRC8A LOC768589 LOC768589 MYRIP MYRIP CCN3 CCN3 PICK1 PICK1 CCL5 CCL5 CFTR CFTR IL1B IL1B ENSA ENSA C2CD2L C2CD2L PDX1 PDX1 ADCY8 ADCY8 SYT7 SYT7 CAPN10 CAPN10 NOS2 NOS2 CDV3 CDV3 HADH HADH SIRT6 SIRT6 HMGN2P46 HMGN2P46 MIDN MIDN ACVR1C ACVR1C GIP GIP REST REST STXBP4 STXBP4 IL6 IL6 NR1D1 NR1D1 TM7SF3 TM7SF3 TSSC1 TSSC1 PRKN PRKN SIRT4 SIRT4 GPLD1 GPLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYTL4Synaptotagmin like 4. (690 aa)
NR0B2NR LBD domain-containing protein. (262 aa)
C1QTNF12C1q and TNF related 12. (320 aa)
C26H6ORF125Uncharacterized protein. (125 aa)
AACSAcetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). (743 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
PSMD9PDZ domain-containing protein. (207 aa)
SYT9Synaptotagmin 9. (528 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
ABCC8ATP binding cassette subfamily C member 8. (1595 aa)
RBP4ARetinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa)
FAM3DFamily with sequence similarity 3 member D. (226 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
KLF7Uncharacterized protein. (296 aa)
SRIUncharacterized protein. (297 aa)
NR1H4Farnesoid X receptor. (473 aa)
PLA2G6Uncharacterized protein. (796 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
RFX6Regulatory factor X6. (916 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (133 aa)
BLKTyrosine-protein kinase. (526 aa)
MTNR1BMelatonin receptor type 1B; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (361 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (397 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (863 aa)
BIRC5Uncharacterized protein. (142 aa)
PIM3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (323 aa)
NDUFAF2Uncharacterized protein. (171 aa)
RPH3ALUncharacterized protein. (295 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (392 aa)
GLUD2Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
LOC768589Uncharacterized protein. (173 aa)
MYRIPRab_eff_C domain-containing protein. (666 aa)
CCN3CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa)
PICK1Protein interacting with PRKCA 1. (408 aa)
CCL5C-C motif chemokine. (90 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
ENSAAlpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). (117 aa)
C2CD2LSMP_C2CD2L domain-containing protein. (707 aa)
PDX1Homeobox domain-containing protein. (259 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
SYT7Synaptotagmin 7. (403 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity); Belongs to the NOS family. (1136 aa)
CDV3Protein CDV3 homolog. (204 aa)
HADHUncharacterized protein. (350 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
HMGN2P46High mobility group nucleosome-binding domain-containing protein 3. (140 aa)
MIDNMidnolin. (444 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
GIPGLUCAGON domain-containing protein. (139 aa)
RESTUncharacterized protein. (339 aa)
STXBP4Syntaxin binding protein 4. (736 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (678 aa)
TM7SF3Transmembrane 7 superfamily member 3. (563 aa)
TSSC1WD_REPEATS_REGION domain-containing protein. (395 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
SIRT4Sirtuin 4. (332 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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