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| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa) |
| | TPRG1L | Tumor protein p63 regulated 1 like. (270 aa) |
| | KBP | Probable glutamate receptor; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (461 aa) |
| | RAP1A | Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa) |
| | LZTS1 | Leucine zipper tumor suppressor 1. (604 aa) |
| | NPTN | Uncharacterized protein. (397 aa) |
| | PHF24 | PHD finger protein 24. (400 aa) |
| | SNCG | Gamma-synuclein; Belongs to the synuclein family. (128 aa) |
| | GRIK3 | Glutamate ionotropic receptor kainate type subunit 3. (919 aa) |
| | UNC13B | Unc-13 homolog B. (1574 aa) |
| | NCDN | Neurochondrin; Probably involved in signal transduction, in the nervous system. Required for the spatial learning process. May also be involved in neurite outgrowth (By similarity); Belongs to the neurochondrin family. (702 aa) |
| | LRRTM2 | Leucine rich repeat transmembrane neuronal 2. (515 aa) |
| | GRM4 | Glutamate metabotropic receptor 4. (917 aa) |
| | HOMER3-2 | WH1 domain-containing protein. (353 aa) |
| | DGKE | Diacylglycerol kinase. (550 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (620 aa) |
| | NPTX2 | Neuronal pentraxin 2. (434 aa) |
| | NTNG2 | Netrin G2. (527 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (240 aa) |
| | GRM2 | Glutamate metabotropic receptor 2. (883 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa) |
| | CACNG5 | Calcium voltage-gated channel auxiliary subunit gamma 5. (279 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | CNR2 | Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | RIMS4 | Regulating synaptic membrane exocytosis 4. (446 aa) |
| | SYT12 | C2 domain-containing protein. (417 aa) |
| | TSHZ3 | Teashirt zinc finger homeobox 3. (1079 aa) |
| | CUX2 | Homeobox protein cut-like. (1386 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (442 aa) |
| | ERC2 | ELKS/RAB6-interacting/CAST family member 2. (979 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | ABHD6 | Abhydrolase domain containing 6. (338 aa) |
| | GRIK4 | Glutamate ionotropic receptor kainate type subunit 4. (959 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1351 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1458 aa) |
| | SLC24A1 | Sodium/potassium/calcium exchanger 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). (663 aa) |
| | DRD2 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1210 aa) |
| | RAPSN | 43 kDa receptor-associated protein of the synapse; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity). Belongs to the RAPsyn family. (412 aa) |
| | RASGRF1 | Ras protein specific guanine nucleotide releasing factor 1. (1284 aa) |
| | NEURL1 | Uncharacterized protein. (555 aa) |
| | VPS18 | Pep3_Vps18 domain-containing protein. (974 aa) |
| | PPP3R1 | Protein phospatase 3 regulatory subunit B alpha isoform type 1. (170 aa) |
| | GIPC2 | GIPC PDZ domain containing family member 2. (318 aa) |
| | SNAP25 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity). Belongs to the SNAP-25 family. (206 aa) |
| | NCSTN | Ncstrn_small domain-containing protein. (717 aa) |
| | FMR1 | Fragile X mental retardation 1. (548 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1656 aa) |
| | SLC7A11 | Solute carrier family 7 member 11 xCT. (501 aa) |
| | LRFN2 | Leucine rich repeat and fibronectin type III domain containing 2. (763 aa) |
| | GRID2 | Glutamate ionotropic receptor delta type subunit 2. (922 aa) |
| | LRP8 | Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa) |
| | LGMN | Legumain. (431 aa) |
| | BDKRB2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | CYP46A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa) |
| | HCRT | Uncharacterized protein. (148 aa) |
| | AKAP5 | Uncharacterized protein. (596 aa) |
| | GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B. (1504 aa) |
| | SCTR | Secretin receptor; Belongs to the G-protein coupled receptor 2 family. (449 aa) |
| | SYNGR1 | Synaptogyrin. (233 aa) |
| | RAB3GAP1 | RAB3 GTPase activating protein catalytic subunit 1. (1014 aa) |
| | PLA2G6 | Uncharacterized protein. (796 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1152 aa) |
| | EDN1 | Endothelin 1. (194 aa) |
| | CGTL | Uncharacterized protein. (474 aa) |
| | DGKI | Diacylglycerol kinase. (1073 aa) |
| | CHRM2 | Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. (466 aa) |
| | SCGN | Secretagogin, EF-hand calcium binding protein. (273 aa) |
| | CLSTN3 | Calsyntenin 3. (1024 aa) |
| | F1NA95_CHICK | AKAP7_NLS domain-containing protein. (256 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (425 aa) |
| | CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa) |
| | ROR2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa) |
| | GRIK2 | Glutamate ionotropic receptor kainate type subunit 2. (917 aa) |
| | GRIN3A | Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa) |
| | RASGRF2 | Ras protein specific guanine nucleotide releasing factor 2. (1232 aa) |
| | RIMS1 | C2 domain-containing protein. (261 aa) |
| | LRRTM1 | Leucine rich repeat transmembrane neuronal 1. (521 aa) |
| | ARC | Activity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis- dependent forms [...] (404 aa) |
| | RNF19AL | RBR-type E3 ubiquitin transferase. (525 aa) |
| | SYAP1 | BSD domain-containing protein. (357 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa) |
| | NALCN | Sodium leak channel, non-selective. (1738 aa) |
| | GRM5 | G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa) |
| | ADORA2B | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa) |
| | NRGN | Uncharacterized protein. (73 aa) |
| | S100B | EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (436 aa) |
| | KCNB1 | Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (863 aa) |
| | CLSTN1 | Uncharacterized protein. (971 aa) |
| | PNKD | PNKD metallo-beta-lactamase domain containing. (313 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | ATF4 | ATF4. (354 aa) |
| | BTBD9 | BTB domain-containing protein. (647 aa) |
| | ACE | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa) |
| | GRIN2C | Glutamate ionotropic receptor NMDA type subunit 2C. (1301 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa) |
| | LOC100858919 | Uncharacterized protein. (580 aa) |
| | NLGN3 | Neuroligin 3 isoform A1A2. (853 aa) |
| | CALB2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa) |
| | CPLX3 | Uncharacterized protein. (157 aa) |
| | TROJANZ | Uncharacterized protein. (494 aa) |
| | CPLX2 | Uncharacterized protein. (134 aa) |
| | CACNG4 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa) |
| | AKAP12 | A-kinase anchoring protein 12. (1917 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa) |
| | NPTXR | Neuronal pentraxin receptor. (475 aa) |
| | NTNG1 | Netrin G1. (483 aa) |
| | UNC13A | Uncharacterized protein. (1738 aa) |
| | STX1A | Syntaxin 1A; Belongs to the syntaxin family. (407 aa) |
| | ABR | ABR activator of RhoGEF and GTPase. (873 aa) |
| | STX2 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (288 aa) |
| | SLC4A10 | Anion exchange protein. (1116 aa) |
| | UNC13C | Uncharacterized protein. (1097 aa) |
| | RAB26 | RAB26, member RAS oncogene family. (190 aa) |
| | YTHDF1 | YTH domain-containing protein. (561 aa) |
| | RIMS1-2 | PDZ domain-containing protein. (506 aa) |
| | BAIAP2 | BAI1 associated protein 2. (573 aa) |
| | SHISA9 | Shisa family member 9. (274 aa) |
| | NLGN1 | Neuroligin 1 isoform A1A2B. (863 aa) |
| | SNCAIP | Synuclein alpha interacting protein. (960 aa) |
| | BEGAIN | Brain enriched guanylate kinase associated. (653 aa) |
| | RNF19A | RBR-type E3 ubiquitin transferase. (820 aa) |
| | DLGAP4 | DLG associated protein 4. (985 aa) |
| | PINK1 | PTEN induced kinase 1. (364 aa) |
| | GRID2IP | Grid2 interacting protein. (993 aa) |
| | SLC6A1 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (598 aa) |
| | PICK1 | Protein interacting with PRKCA 1. (408 aa) |
| | CDH15 | Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa) |
| | PIBPPDD4L | Phosphoinositide phospholipase C. (1139 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (944 aa) |
| | DISC1 | DISC1 scaffold protein. (856 aa) |
| | STXBP5L | Syntaxin binding protein 5 like. (1184 aa) |
| | CA7 | Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (259 aa) |
| | DLGAP1 | DLG associated protein 1. (975 aa) |
| | SLC4A8 | Anion exchange protein. (1068 aa) |
| | SHANK2 | SH3 and multiple ankyrin repeat domains 2. (1462 aa) |
| | SYT4 | Synaptotagmin 4. (425 aa) |
| | GIT2 | Uncharacterized protein. (757 aa) |
| | CACNB4 | SH3 domain-containing protein. (480 aa) |
| | GRID1 | Glutamate ionotropic receptor delta type subunit 1. (928 aa) |
| | PPP1R9B | Protein phosphatase 1 regulatory subunit 9B. (790 aa) |
| | DLGAP3 | DLG associated protein 3. (960 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa) |
| | GRM8 | Glutamate metabotropic receptor 8. (908 aa) |
| | CPLX4 | Complexin 4. (130 aa) |
| | GRIK1 | Glutamate ionotropic receptor kainate type subunit 1. (926 aa) |
| | NRXN1 | Neurexin-1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. (1503 aa) |
| | LRRK2 | Uncharacterized protein. (2557 aa) |
| | GRIA1 | Uncharacterized protein. (902 aa) |
| | SQSTM1 | Sequestosome 1. (453 aa) |
| | NPAS4 | BHLH domain-containing protein. (67 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | PPP1R9B-2 | Uncharacterized protein. (1349 aa) |
| | DLGAP2 | DLG associated protein 2. (1031 aa) |
| | CALB1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa) |
| | ATAD1 | ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (362 aa) |
| | SYT7 | Synaptotagmin 7. (403 aa) |
| | HOMER1 | Homer scaffold protein 1. (358 aa) |
| | CLSTN2 | Calsyntenin 2. (866 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa) |
| | CACNG2 | Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa) |
| | MCTP2 | Multiple C2 and transmembrane domain containing 2. (895 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (539 aa) |
| | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis. (1042 aa) |
| | EIF4EBP2 | Uncharacterized protein. (114 aa) |
| | ENSGALP00000059595 | Uncharacterized protein. (194 aa) |
| | TMEM108 | Transmembrane protein 108. (476 aa) |
| | SLC24A2 | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (651 aa) |
| | PTPRA | Uncharacterized protein. (867 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | GNAI3 | G protein alpha subunit. (354 aa) |
| | SHISA8 | Uncharacterized protein. (359 aa) |
| | ENSGALP00000064934 | Uncharacterized protein. (2030 aa) |
| | ENSGALP00000065007 | Uncharacterized protein. (162 aa) |
| | RIMS2 | Regulating synaptic membrane exocytosis 2. (1495 aa) |
| | UNC13C-2 | Uncharacterized protein. (411 aa) |
| | SLC6A6 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (708 aa) |
| | ENSGALP00000065860 | LRRCT domain-containing protein. (525 aa) |
| | SORCS2 | Sortilin related VPS10 domain containing receptor 2. (1169 aa) |
| | STX3 | Syntaxin 3; Belongs to the syntaxin family. (462 aa) |
| | LAMA2 | Uncharacterized protein. (598 aa) |
| | LDLR | Uncharacterized protein. (302 aa) |
| | NLGN2 | Neuroligin 2. (599 aa) |
| | PPP1R9A | Protein phosphatase 1 regulatory subunit 9A. (1342 aa) |
| | CNR1 | Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (495 aa) |
| | LGI1 | LRRCT domain-containing protein. (543 aa) |
| | APBA1 | Amyloid beta precursor protein binding family A member 1. (824 aa) |
| | DGKZ | Diacylglycerol kinase. (1139 aa) |
| | STXBP5 | Syntaxin binding protein 5. (1152 aa) |
| | IGSF11 | Uncharacterized protein. (445 aa) |
| | AKAP7 | A-kinase anchoring protein 7. (468 aa) |
| | USP8-2 | Rhodanese domain-containing protein. (602 aa) |
| | DTNBP1 | Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa) |
| | PXK | PX domain containing serine/threonine kinase like. (577 aa) |
| | CDK5 | Protein kinase domain-containing protein. (522 aa) |
| | NETO1 | Neuropilin and tolloid like 1. (541 aa) |
| | ZDHHC12 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (261 aa) |
| | ENSGALP00000069004 | Uncharacterized protein. (154 aa) |
| | NLGN4Y | Neuroligin 4 isoform A2. (836 aa) |
| | ZZEF1 | Zinc finger ZZ-type and EF-hand domain containing 1. (2898 aa) |
| | TRARG1 | Trafficking regulator of GLUT4 (SLC2A4) 1. (176 aa) |
| | SNAP47 | Synaptosome associated protein 47. (461 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa) |
| | GIT1 | ANK_REP_REGION domain-containing protein. (791 aa) |
| | FRRS1L | Ferric chelate reductase 1 like. (290 aa) |
| | RIMS3 | Regulating synaptic membrane exocytosis 3. (377 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons. (270 aa) |
| | ENSGALP00000070440 | Uncharacterized protein. (167 aa) |
| | MECP2 | Methyl-CpG binding protein 2. (208 aa) |
| | GRM7 | Glutamate metabotropic receptor 7. (1163 aa) |
| | NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa) |
| | RAP1B | Ras-related protein Rap-1b. (268 aa) |
| | NPS | Neuropeptide S. (99 aa) |
| | ENSGALP00000070829 | Uncharacterized protein. (84 aa) |
| | UCN | Urocortin. (100 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (552 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2. (460 aa) |
| | CACNG7 | Calcium voltage-gated channel auxiliary subunit gamma 7. (126 aa) |
| | HRAS | GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1121 aa) |
| | LOC100858953 | Fibronectin type-III domain-containing protein. (572 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa) |
| | S1PR2 | Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | MCTP1 | Multiple C2 and transmembrane domain containing 1. (954 aa) |
| | SLC1A3 | Amino acid transporter. (543 aa) |
| | ENSGALP00000074158 | LAM_G_DOMAIN domain-containing protein. (326 aa) |
| | ENSGALP00000074167 | Uncharacterized protein. (178 aa) |
