(29 nodes) Negative regulation of synaptic transmission network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAP1A	Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
	CNR2	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	ABHD6	Abhydrolase domain containing 6. (338 aa)
	SLC24A1	Sodium/potassium/calcium exchanger 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). (663 aa)
	DRD2	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	ADNP	Activity dependent neuroprotector homeobox. (1210 aa)
	FMR1	Fragile X mental retardation 1. (548 aa)
	PLA2G6	Uncharacterized protein. (796 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (425 aa)
	PNKD	PNKD metallo-beta-lactamase domain containing. (313 aa)
	GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
	GRID2IP	Grid2 interacting protein. (993 aa)
	SLC6A1	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (598 aa)
	PICK1	Protein interacting with PRKCA 1. (408 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1462 aa)
	SYT4	Synaptotagmin 4. (425 aa)
	LRRK2	Uncharacterized protein. (2557 aa)
	GRIA1	Uncharacterized protein. (902 aa)
	SRF	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (362 aa)
	SLC24A2	Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (651 aa)
	GNAI3	G protein alpha subunit. (354 aa)
	SORCS2	Sortilin related VPS10 domain containing receptor 2. (1169 aa)
	CNR1	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (495 aa)
	RAP1B	Ras-related protein Rap-1b. (268 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
	GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2. (460 aa)
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD6	DRD2	ENSGALP00000009124	ENSGALP00000012625	Abhydrolase domain containing 6.	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	0.695
CNR1	CNR2	ENSGALP00000066943	ENSGALP00000006552	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family.	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.907
CNR1	DRD2	ENSGALP00000066943	ENSGALP00000012625	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	0.406
CNR2	CNR1	ENSGALP00000006552	ENSGALP00000066943	Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family.	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family.	0.907
DRD2	ABHD6	ENSGALP00000012625	ENSGALP00000009124	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Abhydrolase domain containing 6.	0.695
DRD2	CNR1	ENSGALP00000012625	ENSGALP00000066943	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family.	0.406
DRD2	GNAI1	ENSGALP00000012625	ENSGALP00000044195	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.955
DRD2	GNAI2	ENSGALP00000012625	ENSGALP00000072608	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.960
DRD2	GNAI3	ENSGALP00000012625	ENSGALP00000062750	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	G protein alpha subunit.	0.955
DRD2	GRIA1	ENSGALP00000012625	ENSGALP00000052753	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.429
DRD3	GNAI1	ENSGALP00000024343	ENSGALP00000044195	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.514
DRD3	GNAI2	ENSGALP00000024343	ENSGALP00000072608	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.514
DRD3	GNAI3	ENSGALP00000024343	ENSGALP00000062750	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G protein alpha subunit.	0.514
GNAI1	DRD2	ENSGALP00000044195	ENSGALP00000012625	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	0.955
GNAI1	DRD3	ENSGALP00000044195	ENSGALP00000024343	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.514
GNAI1	GNAI2	ENSGALP00000044195	ENSGALP00000072608	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.902
GNAI1	GNAI3	ENSGALP00000044195	ENSGALP00000062750	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	G protein alpha subunit.	0.905
GNAI2	DRD2	ENSGALP00000072608	ENSGALP00000012625	Guanine nucleotide-binding protein G(i) subunit alpha-2.	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family.	0.960
GNAI2	DRD3	ENSGALP00000072608	ENSGALP00000024343	Guanine nucleotide-binding protein G(i) subunit alpha-2.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.514
GNAI2	GNAI1	ENSGALP00000072608	ENSGALP00000044195	Guanine nucleotide-binding protein G(i) subunit alpha-2.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.902