STRINGSTRING
SUPT6H SUPT6H IL10 IL10 STAT5A STAT5A ATAD5 ATAD5 PMS2 PMS2 CARD11 CARD11 PARP3 PARP3 XBP1 XBP1 HMCES HMCES BCL6 BCL6 TFRC TFRC NFATC2 NFATC2 CTLA4 CTLA4 PELI3 PELI3 MSH2 MSH2 PPP2R3C PPP2R3C PAWR PAWR IL21 IL21 BANK1 BANK1 BCL2 BCL2 IKZF3 IKZF3 KMT5B KMT5B SYK SYK WHSC1-2 WHSC1-2 AKIRIN2 AKIRIN2 BLK BLK TNFRSF21 TNFRSF21 TNFSF13B TNFSF13B GPR183 GPR183 ATM ATM TNFRSF13C TNFRSF13C RIF1 RIF1 CD40 CD40 MSH6 MSH6 TNFRSF13B TNFRSF13B BST1 BST1 THEMIS2 THEMIS2 TNIP2 TNIP2 MLH1 MLH1 SHLD3 SHLD3 TNFAIP3 TNFAIP3 LYN LYN TP53BP1 TP53BP1 SAMSN1 SAMSN1 INPP5D INPP5D IL7 IL7 IL2RG IL2RG PTPRC PTPRC SASH3 SASH3 NDFIP1 NDFIP1 THOC1 THOC1 PCID2 PCID2 CD38 CD38 TIRAP TIRAP CD74 CD74 CLCF1 CLCF1 SHLD1 SHLD1 ENSGALP00000065981 ENSGALP00000065981 WHSC1 WHSC1 MORN5 MORN5 EXOSC3 EXOSC3 IL6 IL6 RC3H1 RC3H1 TBX21 TBX21 NFAM1 NFAM1 KMT5C KMT5C TNFRSF4 TNFRSF4 ENSGALP00000072274 ENSGALP00000072274 PTPN6 PTPN6 ENSGALP00000073333 ENSGALP00000073333 LOC112530959 LOC112530959 STAT6 STAT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
ATAD5AAA domain-containing protein. (1816 aa)
PMS2Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa)
CARD11Uncharacterized protein. (1170 aa)
PARP3Poly [ADP-ribose] polymerase. (526 aa)
XBP1BZIP domain-containing protein. (372 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (336 aa)
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
PELI3Uncharacterized protein. (418 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (942 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (461 aa)
PAWRPro-apoptotic WT1 regulator. (337 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (730 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
IKZF3Uncharacterized protein. (509 aa)
KMT5BLysine methyltransferase 5B. (857 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
WHSC1-2Uncharacterized protein. (592 aa)
AKIRIN2Akirin. (191 aa)
BLKTyrosine-protein kinase. (526 aa)
TNFRSF21Uncharacterized protein. (651 aa)
TNFSF13BTNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (371 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
TNFRSF13CBaffR-Tall_bind domain-containing protein. (213 aa)
RIF1Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity). (2168 aa)
CD40Uncharacterized protein. (299 aa)
MSH6DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (1342 aa)
TNFRSF13BTNFR-Cys domain-containing protein. (259 aa)
BST1ADP-ribosyl cyclase CD157. (316 aa)
THEMIS2Thymocyte selection associated family member 2. (576 aa)
TNIP2CCHC NOA-type domain-containing protein. (521 aa)
MLH1DNA mismatch repair protein MLH1. (757 aa)
SHLD3Shieldin complex subunit 3. (249 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
LYNTyrosine-protein kinase. (491 aa)
TP53BP1Tumor protein p53 binding protein 1. (1907 aa)
SAMSN1Uncharacterized protein. (373 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1145 aa)
IL7Interleukin-7. (146 aa)
IL2RGFibronectin type-III domain-containing protein. (384 aa)
PTPRCUncharacterized protein. (1237 aa)
SASH3Uncharacterized protein. (382 aa)
NDFIP1Nedd4 family interacting protein 1. (213 aa)
THOC1Death domain-containing protein. (671 aa)
PCID2PCI domain-containing protein. (399 aa)
CD38Uncharacterized protein. (308 aa)
TIRAPTIR domain-containing protein. (231 aa)
CD74Invariant chain isoform p41. (286 aa)
CLCF1Cardiotrophin like cytokine factor 1. (356 aa)
SHLD1Shieldin complex subunit 1. (240 aa)
ENSGALP00000065981TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (164 aa)
WHSC1Uncharacterized protein. (537 aa)
MORN5Uncharacterized protein. (297 aa)
EXOSC3KH_dom_type_1 domain-containing protein. (288 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
RC3H1Ring finger and CCCH-type domains 1. (1114 aa)
TBX21T-box transcription factor 21. (580 aa)
NFAM1Uncharacterized protein. (323 aa)
KMT5CLysine methyltransferase 5C. (449 aa)
TNFRSF4Uncharacterized protein. (287 aa)
ENSGALP00000072274TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (126 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa)
ENSGALP00000073333Ig-like domain-containing protein. (176 aa)
LOC112530959STAT_int domain-containing protein. (392 aa)
STAT6SH2 domain-containing protein. (183 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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