(63 nodes) Positive regulation of chemotaxis network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PRSS56	Peptidase S1 domain-containing protein. (483 aa)
	EDN2	Endothelin-2. (179 aa)
	C1QBP	Complement C1q binding protein. (214 aa)
	CREB3	cAMP responsive element binding protein 3. (390 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (625 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (385 aa)
	ADAM10	Uncharacterized protein. (749 aa)
	CSF1R	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
	CXCL14	Jun-suppressed chemokine. (98 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1454 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (203 aa)
	THBS1	Uncharacterized protein. (1175 aa)
	ANO6	Anoctamin. (912 aa)
	CXCL13L2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (100 aa)
	LGMN	Legumain. (431 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
	IL8L1	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	CCR8L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	C3AR1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (461 aa)
	KDR	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
	XCL1	Lymphotactin. (97 aa)
	DSCAM	Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (2034 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (992 aa)
	MOSPD2	Uncharacterized protein. (517 aa)
	ADAM17	Tumor necrosis factor alpha converting enzyme. (829 aa)
	CCR6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	IL34	Interleukin 34. (178 aa)
	CCL19-2	SCY domain-containing protein. (99 aa)
	SCG2	Secretogranin II. (629 aa)
	GAS6	Growth arrest specific 6. (667 aa)
	FAM65B	Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Requ [...] (1067 aa)
	SLIT2	Uncharacterized protein. (1533 aa)
	MSTN	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa)
	ENSGALP00000045895	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	CXCL12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
	CCR7	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	GDF11	Growth differentiation factor 11. (368 aa)
	CCL5	C-C motif chemokine. (90 aa)
	CXCL13L3	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	MET	Uncharacterized protein. (1382 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	VEGFD	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (378 aa)
	RARRES2	Chemerin. (162 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ARTN	Artemin. (259 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
	TIRAP	TIR domain-containing protein. (231 aa)
	K4LB56_CHICK	CD150. (333 aa)
	CD74	Invariant chain isoform p41. (286 aa)
	CXCL13	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	CSF1	Uncharacterized protein. (493 aa)
	STK39	Serine/threonine kinase 39. (615 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (247 aa)
	C5AR1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	VEGFA	Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
	CCL19	C-C motif chemokine. (108 aa)
	SUCNR1	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (317 aa)
	S100A14	S_100 domain-containing protein; Belongs to the S-100 family. (420 aa)
	CMKLR1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	DNM1L	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa)
	OXSR1	Oxidative stress responsive kinase 1. (533 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	ADAM17	ENSGALP00000006687	ENSGALP00000030970	Uncharacterized protein.	Tumor necrosis factor alpha converting enzyme.	0.462
ADAM10	CX3CR1	ENSGALP00000006687	ENSGALP00000057621	Uncharacterized protein.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.587
ADAM10	VEGFD	ENSGALP00000006687	ENSGALP00000055963	Uncharacterized protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.447
ADAM17	ADAM10	ENSGALP00000030970	ENSGALP00000006687	Tumor necrosis factor alpha converting enzyme.	Uncharacterized protein.	0.462
ADAM17	CX3CR1	ENSGALP00000030970	ENSGALP00000057621	Tumor necrosis factor alpha converting enzyme.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.406
C1QBP	CSF1	ENSGALP00000002522	ENSGALP00000064854	Complement C1q binding protein.	Uncharacterized protein.	0.420
C3AR1	C5AR1	ENSGALP00000021561	ENSGALP00000066054	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.541
C3AR1	CSF1R	ENSGALP00000021561	ENSGALP00000009176	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.578
C3AR1	ENSGALP00000045895	ENSGALP00000021561	ENSGALP00000045895	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.400
C5AR1	C3AR1	ENSGALP00000066054	ENSGALP00000021561	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.541
C5AR1	ENSGALP00000045895	ENSGALP00000066054	ENSGALP00000045895	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.400
CCL19	CCL19-2	ENSGALP00000068348	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.841
CCL19	CCL5	ENSGALP00000068348	ENSGALP00000049143	C-C motif chemokine.	C-C motif chemokine.	0.988
CCL19	CCR6	ENSGALP00000068348	ENSGALP00000031194	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.868
CCL19	CCR7	ENSGALP00000068348	ENSGALP00000048400	C-C motif chemokine.	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL19	CCR8L	ENSGALP00000068348	ENSGALP00000019143	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.612
CCL19	CX3CR1	ENSGALP00000068348	ENSGALP00000057621	C-C motif chemokine.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.700
CCL19	CXCL12	ENSGALP00000068348	ENSGALP00000047558	C-C motif chemokine.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.994
CCL19	CXCL13	ENSGALP00000068348	ENSGALP00000064345	C-C motif chemokine.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.931
CCL19	CXCL13L2	ENSGALP00000068348	ENSGALP00000016813	C-C motif chemokine.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.512