STRINGSTRING
FANCA FANCA WWP2 WWP2 NR0B2 NR0B2 IL10 IL10 TERF2IP TERF2IP TAF12 TAF12 PRKCZ PRKCZ TRAF1 TRAF1 CARD9 CARD9 SETD6 SETD6 CREB3 CREB3 SIRT1 SIRT1 TRADD TRADD CRTC1 CRTC1 FANCD2 FANCD2 SIGIRR SIGIRR CARD11 CARD11 BUD31 BUD31 TRIM37 TRIM37 MED13 MED13 PKD1 PKD1 SMARCB1 SMARCB1 WHAMM WHAMM COMMD7 COMMD7 TAF3 TAF3 IRG1L IRG1L MAP2K5 MAP2K5 SUFU SUFU PSMD10 PSMD10 CIB4 CIB4 CAV3 CAV3 DDR1 DDR1 NEUROD1 NEUROD1 COMMD1 COMMD1 SRI SRI EIF2AK4 EIF2AK4 TRAF5 TRAF5 CYLD CYLD PSMA6 PSMA6 EIF2AK2 EIF2AK2 LRP8 LRP8 PLPP3 PLPP3 ROR1 ROR1 CTH CTH IHH IHH NR1H4 NR1H4 EP300 EP300 SAV1 SAV1 EDN1 EDN1 KDM5A KDM5A DAP DAP NTRK1 NTRK1 TLR3 TLR3 JMY JMY CLUL1 CLUL1 CYTL1 CYTL1 TRIM14 TRIM14 CD200 CD200 WFS1 WFS1 UFL1 UFL1 DDRGK1 DDRGK1 NR0B1 NR0B1 IL18RAP IL18RAP TFDP1 TFDP1 ACOD1 ACOD1 RGCC RGCC FZD4 FZD4 ANKRD42 ANKRD42 ARHGEF5 ARHGEF5 RPS3 RPS3 JUP JUP PLA2G10L PLA2G10L RWDD1 RWDD1 CHP1 CHP1 RNF220 RNF220 SLCO3A1 SLCO3A1 PLA2G10 PLA2G10 RAB7B RAB7B APP APP RIPK1 RIPK1 GREM1 GREM1 RNF25 RNF25 CD40 CD40 PRKCI PRKCI PELI3 PELI3 CACTIN CACTIN TNFSF11 TNFSF11 NTS NTS CX3CL1 CX3CL1 CRNN CRNN EOMES EOMES NFKBIA NFKBIA TRIM62 TRIM62 TRAIP TRAIP CAV1 CAV1 COPS5 COPS5 CDK5RAP3 CDK5RAP3 HAND1 HAND1 GAS6 GAS6 TRAPPC9 TRAPPC9 NLRC3 NLRC3 FAF1 FAF1 CTNNB1 CTNNB1 NDP NDP ENSGALP00000045895 ENSGALP00000045895 AR AR ABRA ABRA RIPK4 RIPK4 POU4F1 POU4F1 MALT1 MALT1 RIPK2 RIPK2 PIAS4 PIAS4 TNFAIP3 TNFAIP3 ZC3H12A ZC3H12A PINK1 PINK1 RELA RELA KDM1A KDM1A CYP1B1 CYP1B1 PKD2 PKD2 DDIT3 DDIT3 FAM105A FAM105A SMO SMO IL1B IL1B DDR2 DDR2 CARF CARF KIT KIT CHUK CHUK NLRC5 NLRC5 IKBKB IKBKB ID1 ID1 LRP6 LRP6 PCASP3 PCASP3 EDA EDA TRIM8 TRIM8 CAPN3 CAPN3 PPARGC1A PPARGC1A ADCY1 ADCY1 ADCY8 ADCY8 PRDX3 PRDX3 SMAD7 SMAD7 SRF SRF USP7 USP7 CEBPG CEBPG CYP1C1 CYP1C1 ITCH ITCH NOD1 NOD1 ID3 ID3 MTPN MTPN SMAD7B SMAD7B BHLHE40 BHLHE40 PPRC1 PPRC1 PCASP2 PCASP2 NWD2 NWD2 EDA2R EDA2R CX3CR1 CX3CR1 RPS6KA5 RPS6KA5 LOC420294 LOC420294 LOC107051192 LOC107051192 DHX33 DHX33 PEX14 PEX14 ENSGALP00000061859 ENSGALP00000061859 TIRAP TIRAP LOC770026 LOC770026 FLOT2 FLOT2 RWDD3 RWDD3 TNFRSF11A TNFRSF11A CAT CAT PDLIM7 PDLIM7 LOC112530987 LOC112530987 NFKBIB NFKBIB LDLR LDLR ENSGALP00000066589 ENSGALP00000066589 C14orf39 C14orf39 TRAF3 TRAF3 MBTPS2 MBTPS2 ENSGALP00000067121 ENSGALP00000067121 OTULIN OTULIN HES6 HES6 PKHD1 PKHD1 IL6 IL6 STK36 STK36 GLIS2 GLIS2 TRAF6 TRAF6 CRTC2 CRTC2 RELT RELT MYOCD MYOCD SHARPIN SHARPIN ENSGALP00000069823 ENSGALP00000069823 TRAF2 TRAF2 LPAR5 LPAR5 CMKLR1 CMKLR1 COMMD6 COMMD6 ENSGALP00000071132 ENSGALP00000071132 ARID5B ARID5B RIPK3 RIPK3 RB1 RB1 NFAM1 NFAM1 C3orf33 C3orf33 ZC4H2 ZC4H2 ENSGALP00000072166 ENSGALP00000072166 IRAK2 IRAK2 TNFRSF4 TNFRSF4 CTNNBIP1 CTNNBIP1 FLOT1 FLOT1 TNFRSF19 TNFRSF19 RLIM RLIM IL1RAP IL1RAP ENSGALP00000074194 ENSGALP00000074194
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCAFanconi_A_N domain-containing protein. (1653 aa)
WWP2E3 ubiquitin-protein ligase. (924 aa)
NR0B2NR LBD domain-containing protein. (262 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (409 aa)
TAF12TFIID_20kDa domain-containing protein. (161 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
CARD9Caspase recruitment domain family member 9. (574 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (447 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
CRTC1CREB regulated transcription coactivator 1. (620 aa)
FANCD2Uncharacterized protein. (1510 aa)
SIGIRRUncharacterized protein. (413 aa)
CARD11Uncharacterized protein. (1170 aa)
BUD31BUD31 homolog. (144 aa)
TRIM37Uncharacterized protein. (983 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2181 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4382 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Involved in chromatin-remodeling. Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). (386 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (711 aa)
COMMD7COMM domain-containing protein. (201 aa)
TAF3Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity). (930 aa)
IRG1LUncharacterized protein. (463 aa)
MAP2K5Uncharacterized protein. (582 aa)
SUFUSuppressor of fused homolog. (484 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CIB4Uncharacterized protein. (190 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
DDR1Uncharacterized protein. (873 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
COMMD1Copper metabolism domain containing 1. (215 aa)
SRIUncharacterized protein. (297 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1656 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
EIF2AK2Uncharacterized protein. (550 aa)
LRP8Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa)
PLPP3acidPPc domain-containing protein. (313 aa)
ROR1Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (896 aa)
CTHCystathionine gamma-lyase. (399 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
NR1H4Farnesoid X receptor. (473 aa)
EP300E1A binding protein p300. (2450 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
EDN1Endothelin 1. (194 aa)
KDM5ALysine demethylase 5A. (1692 aa)
DAPDeath associated protein 1. (104 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (889 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
CYTL1Cytokine like 1. (132 aa)
TRIM14Uncharacterized protein. (433 aa)
CD200Uncharacterized protein. (254 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
UFL1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (789 aa)
DDRGK1DDRGK domain containing 1. (221 aa)
NR0B1NR LBD domain-containing protein. (263 aa)
IL18RAPInterleukin 18 receptor accessory protein. (652 aa)
TFDP1Transcription factor. (411 aa)
ACOD1Uncharacterized protein. (478 aa)
RGCCRegulator of cell cycle. (135 aa)
FZD4Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa)
ANKRD42Ankyrin repeat domain 42. (497 aa)
ARHGEF5Uncharacterized protein. (1733 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
JUPPlakoglobin. (747 aa)
PLA2G10LPhospholipase A(2). (158 aa)
RWDD1RWD domain-containing protein. (240 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
RNF220RING-type domain-containing protein. (305 aa)
SLCO3A1Solute carrier organic anion transporter family member. (705 aa)
PLA2G10Phospholipase A(2). (155 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
RIPK1Uncharacterized protein. (682 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
RNF25RING-type domain-containing protein. (410 aa)
CD40Uncharacterized protein. (299 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
PELI3Uncharacterized protein. (418 aa)
CACTINCactin, spliceosome C complex subunit. (731 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
NTSNeurotensin. (164 aa)
CX3CL1SCY domain-containing protein. (496 aa)
CRNNEF-hand domain-containing protein. (384 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
TRIM62Tripartite motif containing 62. (751 aa)
TRAIPRING-type domain-containing protein. (516 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
COPS5MPN domain-containing protein. (337 aa)
CDK5RAP3Uncharacterized protein. (619 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor (By similarity). Plays an essential role in cardiac morphogenesis. (202 aa)
GAS6Growth arrest specific 6. (667 aa)
TRAPPC9Trafficking protein particle complex 9. (996 aa)
NLRC3NLR family CARD domain containing 3. (1095 aa)
FAF1Fas associated factor 1. (650 aa)
CTNNB1Uncharacterized protein. (781 aa)
NDPCTCK domain-containing protein. (133 aa)
ENSGALP00000045895G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ARUncharacterized protein. (703 aa)
ABRAActin binding Rho activating protein. (403 aa)
RIPK4Receptor interacting serine/threonine kinase 4. (855 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
MALT1MALT1 paracaspase. (816 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (574 aa)
PIAS4Protein inhibitor of activated STAT 4. (493 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (681 aa)
PINK1PTEN induced kinase 1. (364 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
PKD2Uncharacterized protein. (881 aa)
DDIT3C/EBP-like protein. (155 aa)
FAM105AUncharacterized protein. (411 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (901 aa)
CARFCalcium responsive transcription factor. (622 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
NLRC5NACHT domain-containing protein. (1862 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
ID1Helix-loop-helix protein. (118 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
PCASP3Uncharacterized protein. (632 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (364 aa)
TRIM8RING-type domain-containing protein. (551 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
PPARGC1ARRM domain-containing protein. (795 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
PRDX3Peroxiredoxin 3. (309 aa)
SMAD7Mothers against decapentaplegic homolog. (388 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
CEBPGLeucine zipper transcription factor. (150 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
NOD1Uncharacterized protein. (951 aa)
ID3BHLH domain-containing protein. (261 aa)
MTPNMyotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa)
SMAD7BMothers against decapentaplegic homolog. (388 aa)
BHLHE40Uncharacterized protein. (401 aa)
PPRC1PPARG related coactivator 1. (1680 aa)
PCASP2Uncharacterized protein. (741 aa)
NWD2NACHT and WD repeat domain containing 2. (1640 aa)
EDA2RTNFR-Cys domain-containing protein. (504 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcrip [...] (803 aa)
LOC420294Uncharacterized protein; Belongs to the peptidase C19 family. (787 aa)
LOC107051192RanBP2-type domain-containing protein. (1255 aa)
DHX33Uncharacterized protein. (143 aa)
PEX14Peroxisomal biogenesis factor 14. (363 aa)
ENSGALP00000061859Uncharacterized protein. (275 aa)
TIRAPTIR domain-containing protein. (231 aa)
LOC770026Uncharacterized protein. (305 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
RWDD3RWD domain-containing protein. (352 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
PDLIM7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. May be involved in bone formation (By similarity). (425 aa)
LOC112530987Uncharacterized protein. (342 aa)
NFKBIBNFKB inhibitor beta. (320 aa)
LDLRUncharacterized protein. (302 aa)
ENSGALP00000066589Uncharacterized protein. (349 aa)
C14orf39Chromosome 14 open reading frame 39. (589 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (494 aa)
ENSGALP00000067121Costars domain-containing protein. (153 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (319 aa)
HES6Hes family bHLH transcription factor 6. (242 aa)
PKHD1Uncharacterized protein. (551 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
STK36Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (151 aa)
GLIS2Uncharacterized protein. (649 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
CRTC2TORC_N domain-containing protein. (320 aa)
RELTRELT TNF receptor. (335 aa)
MYOCDPhosphatase and actin regulator. (908 aa)
SHARPINSHANK associated RH domain interactor. (481 aa)
ENSGALP00000069823Uncharacterized protein. (167 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CMKLR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
COMMD6COMM domain containing 6. (207 aa)
ENSGALP00000071132Uncharacterized protein. (386 aa)
ARID5BAT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity). (1334 aa)
RIPK3Uncharacterized protein. (424 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
NFAM1Uncharacterized protein. (323 aa)
C3orf33Chromosome 3 open reading frame 33. (240 aa)
ZC4H2Zinc finger C4H2-type containing. (250 aa)
ENSGALP00000072166IPT/TIG domain-containing protein. (239 aa)
IRAK2Protein kinase domain-containing protein. (725 aa)
TNFRSF4Uncharacterized protein. (287 aa)
CTNNBIP1ICAT domain-containing protein. (81 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (876 aa)
TNFRSF19Troy-long. (409 aa)
RLIMRING-type domain-containing protein. (593 aa)
IL1RAPInterleukin 1 receptor accessory protein. (795 aa)
ENSGALP00000074194Uncharacterized protein. (401 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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