STRINGSTRING
SKI SKI PGM5 PGM5 CDH2 CDH2 ADAMTS5 ADAMTS5 SDC1 SDC1 KLF5 KLF5 LMOD3 LMOD3 CD9 CD9 TSTD1 TSTD1 POPDC2 POPDC2 PRKAR1A PRKAR1A TMEM8C TMEM8C BVES BVES MYBPC1 MYBPC1 GREM1 GREM1 IGFBP5 IGFBP5 SPG11 SPG11 MYOD1 MYOD1 LMOD1 LMOD1 ISL1 ISL1 MYH10 MYH10 MAP2K4 MAP2K4 DOCK1 DOCK1 FAM65B FAM65B TBX3 TBX3 TMEM182 TMEM182 CSRP2 CSRP2 TNNT1 TNNT1 PITX2 PITX2 MYH11 MYH11 ACVR1 ACVR1 IRX3 IRX3 CDH15 CDH15 SMO SMO ACTN1 ACTN1 FLII FLII TNNT2 TNNT2 VWA5A VWA5A ATG5 ATG5 MYL6 MYL6 LOC429518 LOC429518 BARX2 BARX2 MEF2C MEF2C BCL2 BCL2 TANC1 TANC1 LRRC40 LRRC40 ASB2 ASB2 PROX1 PROX1 NRAP NRAP LMOD2 LMOD2 NFATC2 NFATC2 LOC430697 LOC430697 AKAP13 AKAP13 ANKRD1 ANKRD1 KLHL40 KLHL40 MYOZ1 MYOZ1 TMOD3 TMOD3 CSRP3 CSRP3 E1C066_CHICK E1C066_CHICK MTOR MTOR DNER DNER NKX2-5 NKX2-5 SELENON SELENON ADRA1A ADRA1A MYOCD MYOCD CSRP1 CSRP1 DOCK5 DOCK5 LRRC10 LRRC10 LOH11CR2A LOH11CR2A ENSGALP00000070799 ENSGALP00000070799 BIN3 BIN3 STAC3 STAC3 NTN3 NTN3 MEF2A MEF2A TMOD4 TMOD4 RB1 RB1 SLC9A1 SLC9A1 ENSGALP00000071672 ENSGALP00000071672 KEL KEL ENSGALP00000072617 ENSGALP00000072617 ENSGALP00000073678 ENSGALP00000073678 PDLIM5 PDLIM5 ITGB7 ITGB7 ENSGALP00000068828 ENSGALP00000068828 SMYD3 SMYD3 TSC1 TSC1 ENSGALP00000068365 ENSGALP00000068365 TMOD1 TMOD1 ENSGALP00000068281 ENSGALP00000068281 ENSGALP00000068191 ENSGALP00000068191 NOX4 NOX4 MYBPC2 MYBPC2 ALPK2 ALPK2 VWA5B2 VWA5B2 SORT1 SORT1 ENSGALP00000066473 ENSGALP00000066473 PTGFRN PTGFRN R3HDM2 R3HDM2 NEBL1 NEBL1 CAV2 CAV2 P2RX2 P2RX2 TNNT3 TNNT3 MYL9 MYL9 SIRT6 SIRT6 IFT20 IFT20 MYL12A MYL12A MYL12B MYL12B MYOZ2 MYOZ2 ZMPSTE24 ZMPSTE24 LRRC10B LRRC10B TBX2 TBX2 TMOD2 TMOD2 HOMER1 HOMER1 SRF SRF ITGB1 ITGB1 CAPN3 CAPN3 MYH9 MYH9 ALPK3 ALPK3 WDR1 WDR1 DOCK2 DOCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKISki oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity). (750 aa)
PGM5Phosphoglucomutase 5. (567 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (877 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (308 aa)
KLF5Kruppel like factor 5. (441 aa)
LMOD3Leiomodin 3. (524 aa)
CD9Tetraspanin. (224 aa)
TSTD1Uncharacterized protein. (358 aa)
POPDC2Uncharacterized protein. (356 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
TMEM8CUncharacterized protein. (220 aa)
BVESBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Involved in epithelial movement during corneal sheet formation and regeneration. May play a role in VAMP3-mediated vesicular transport and recycling of receptor molecules. May play a role in the regulation of cell shape and movement by mod [...] (492 aa)
MYBPC1Myosin binding protein C, slow type. (1227 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
IGFBP5Insulin like growth factor binding protein 5. (269 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2425 aa)
MYOD1Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
LMOD1Leiomodin 1. (624 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
MYH10Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (426 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1866 aa)
FAM65BRho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Requ [...] (1067 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
TMEM182Transmembrane protein 182. (233 aa)
CSRP2Cysteine and glycine-rich protein 2; Totally down-regulated in transformed cells. May therefore take part in the control of cell growth and differentiation. (233 aa)
TNNT1Uncharacterized protein. (272 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
MYH11Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1978 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
IRX3Iroquois homeobox 3. (445 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. (915 aa)
FLIIUncharacterized protein. (1228 aa)
TNNT2Troponin T, cardiac muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (302 aa)
VWA5AVIT domain-containing protein. (845 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
MYL6Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (275 aa)
LOC429518Uncharacterized protein; Belongs to the DOCK family. (1761 aa)
BARX2Homeodomain transcription factor BARX2B. (267 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1830 aa)
LRRC40Leucine-rich repeat-containing protein 40. (603 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (645 aa)
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
NRAPNebulin related anchoring protein. (1736 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
NFATC2Nuclear factor of activated T cells 2. (927 aa)
LOC430697Uncharacterized protein. (393 aa)
AKAP13Uncharacterized protein. (1341 aa)
ANKRD1Ankyrin repeat domain-containing protein 1; May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. (319 aa)
KLHL40Kelch like family member 40. (587 aa)
MYOZ1Myozenin 1. (278 aa)
TMOD3Uncharacterized protein. (352 aa)
CSRP3Uncharacterized protein. (194 aa)
E1C066_CHICKUncharacterized protein. (258 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
DNERDelta/notch like EGF repeat containing. (718 aa)
NKX2-5Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
SELENONUncharacterized protein. (66 aa)
ADRA1AAdrenoceptor alpha 1A. (467 aa)
MYOCDPhosphatase and actin regulator. (908 aa)
CSRP1Cysteine and glycine-rich protein 1; Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression. (192 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1877 aa)
LRRC10Leucine rich repeat containing 10. (248 aa)
LOH11CR2AVIT domain-containing protein. (809 aa)
ENSGALP00000070799SH3 domain-containing protein. (249 aa)
BIN3Bridging integrator 3. (226 aa)
STAC3SH3 and cysteine rich domain 3. (363 aa)
NTN3Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. (644 aa)
MEF2AMyocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development. (545 aa)
TMOD4Uncharacterized protein. (570 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
ENSGALP00000071672VIT domain-containing protein. (136 aa)
KELUncharacterized protein. (720 aa)
ENSGALP00000072617Uncharacterized protein. (1998 aa)
ENSGALP00000073678Uncharacterized protein. (419 aa)
PDLIM5Uncharacterized protein. (623 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (538 aa)
ENSGALP00000068828Uncharacterized protein. (185 aa)
SMYD3SET and MYND domain containing 3. (487 aa)
TSC1Uncharacterized protein. (275 aa)
ENSGALP00000068365Uncharacterized protein. (348 aa)
TMOD1Uncharacterized protein. (359 aa)
ENSGALP00000068281ANK_REP_REGION domain-containing protein. (213 aa)
ENSGALP00000068191Uncharacterized protein. (1629 aa)
NOX4FAD-binding FR-type domain-containing protein. (639 aa)
MYBPC2Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. (254 aa)
ALPK2Uncharacterized protein. (1806 aa)
VWA5B2VWFA domain-containing protein. (465 aa)
SORT1Sortilin. (954 aa)
ENSGALP00000066473Uncharacterized protein. (262 aa)
PTGFRNProstaglandin F2 receptor inhibitor. (872 aa)
R3HDM2Uncharacterized protein. (1218 aa)
NEBL1Uncharacterized protein. (2613 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (507 aa)
TNNT3Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (220 aa)
MYL9Myosin regulatory light chain 2, smooth muscle major isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (172 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
IFT20Intraflagellar transport 20. (132 aa)
MYL12AMyosin regulatory light chain 2, smooth muscle minor isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (198 aa)
MYL12BUncharacterized protein. (172 aa)
MYOZ2Uncharacterized protein. (263 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
LRRC10BLeucine rich repeat containing 10B. (269 aa)
TBX2T-box transcription factor 2. (693 aa)
TMOD2Tropomodulin 2. (351 aa)
HOMER1Homer scaffold protein 1. (358 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
ALPK3Alpha kinase 3. (1545 aa)
WDR1WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity); Belongs to the WD repeat AIP1 family. (609 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1835 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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