STRINGSTRING
CDS2 CDS2 HSPA5 HSPA5 BBS4 BBS4 GPSM2 GPSM2 CREB3 CREB3 BARD1 BARD1 GET4 GET4 FBN1 FBN1 CER1 CER1 PKD1 PKD1 PAFAH1B1 PAFAH1B1 TF TF TBCCD1 TBCCD1 TAF3 TAF3 APOA1 APOA1 FTH1 FTH1 SUFU SUFU PSMD10 PSMD10 CAV3 CAV3 SRI SRI ZFYVE1 ZFYVE1 SUPT7L SUPT7L CDS1 CDS1 RANGAP1 RANGAP1 LATS1 LATS1 PNPLA2 PNPLA2 GOPC GOPC HEXB HEXB INSIG1 INSIG1 PFN4 PFN4 SLC30A7 SLC30A7 NRROS NRROS CASQ2 CASQ2 E1C5H3_CHICK E1C5H3_CHICK TMSB4X TMSB4X SUN2 SUN2 FTL FTL NFKBIA NFKBIA TMEM159 TMEM159 TAF8 TAF8 GM2A GM2A GOLPH3 GOLPH3 INSIG2 INSIG2 YWHAB YWHAB CAV1 CAV1 TWF1 TWF1 RER1 RER1 MORC4 MORC4 ENSGALP00000044402 ENSGALP00000044402 VPS13D VPS13D ALB ALB SQLE SQLE SLC30A8 SLC30A8 FAF1 FAF1 TMSB15B TMSB15B KDELR2 KDELR2 LOC112533280 LOC112533280 SORL1 SORL1 PINK1 PINK1 PKD2 PKD2 IL1B IL1B ENSGALP00000051793 ENSGALP00000051793 UVRAG UVRAG TWF2 TWF2 KDELR3 KDELR3 VPS13A VPS13A POLR2M POLR2M AUP1 AUP1 HSP90B1 HSP90B1 LOC107049174 LOC107049174 TAPT1 TAPT1 LOC428505 LOC428505 CDCA7 CDCA7 HEXA HEXA TSPO2 TSPO2 PLIN2 PLIN2 SPOUT1 SPOUT1 ANGPTL3 ANGPTL3 PMLL PMLL SUN1 SUN1 CD4 CD4 NFKBIB NFKBIB CDC42 CDC42 LOC770839 LOC770839 ACVR1C ACVR1C ENSGALP00000066836 ENSGALP00000066836 ARL2BP ARL2BP CIZ1 CIZ1 IGSF11 IGSF11 FFAR2L FFAR2L TSPO TSPO CDK5 CDK5 CD36 CD36 ENSGALP00000068920 ENSGALP00000068920 PNPLA3 PNPLA3 VPS13C VPS13C STARD4 STARD4 PSEN1 PSEN1 LOC107050658 LOC107050658 TMEM159-2 TMEM159-2 ANKRD13C ANKRD13C TMSB4Y TMSB4Y LDAH LDAH ARHGAP21 ARHGAP21 LOC776146 LOC776146 FITM2 FITM2 NRIP1 NRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (451 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
GPSM2G protein signaling modulator 2. (663 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
BARD1Uncharacterized protein. (795 aa)
GET4Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] (327 aa)
FBN1Fibrillin 1. (2861 aa)
CER1Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4382 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa)
TFOvotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa)
TBCCD1TBCC domain-containing protein 1; May play a role in the regulation of centrosome and Golgi apparatus positioning; Belongs to the TBCC family. (555 aa)
TAF3Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity). (930 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
FTH1Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). (180 aa)
SUFUSuppressor of fused homolog. (484 aa)
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SRIUncharacterized protein. (297 aa)
ZFYVE1Uncharacterized protein. (781 aa)
SUPT7LSPT7 like, STAGA complex gamma subunit. (412 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (454 aa)
RANGAP1RanGAP1_C domain-containing protein. (579 aa)
LATS1Large tumor suppressor kinase 1. (1137 aa)
PNPLA2PNPLA2/ATGL. (483 aa)
GOPCPDZ domain-containing protein. (512 aa)
HEXBBeta-hexosaminidase. (558 aa)
INSIG1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (252 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
SLC30A7Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis (By similarity). Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP. (378 aa)
NRROSNegative regulator of reactive oxygen species. (701 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (406 aa)
E1C5H3_CHICKSUN domain-containing protein. (197 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
SUN2Sad1 and UNC84 domain containing 2. (601 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (278 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
TMEM159Uncharacterized protein. (101 aa)
TAF8Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription (By similarity). (312 aa)
GM2AGM2 ganglioside activator. (118 aa)
GOLPH3Uncharacterized protein. (294 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
YWHAB14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family. (244 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
TWF1Uncharacterized protein. (491 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family. (196 aa)
MORC4CW-type domain-containing protein. (924 aa)
ENSGALP00000044402ANK_REP_REGION domain-containing protein. (216 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4371 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
SQLESE domain-containing protein. (573 aa)
SLC30A8Solute carrier family 30 member 8. (384 aa)
FAF1Fas associated factor 1. (650 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
KDELR2ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4. (212 aa)
LOC112533280ARL2_Bind_BART domain-containing protein. (109 aa)
SORL1Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...] (2205 aa)
PINK1PTEN induced kinase 1. (364 aa)
PKD2Uncharacterized protein. (881 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
UVRAGC2 domain-containing protein. (707 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (385 aa)
KDELR3ER lumen protein-retaining receptor. (203 aa)
VPS13AUncharacterized protein. (3193 aa)
POLR2MRNA polymerase II subunit M. (376 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (406 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). (795 aa)
LOC107049174Uncharacterized protein. (293 aa)
TAPT1Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells; Belongs to the TAPT1 family. (657 aa)
LOC428505SUN domain-containing protein. (246 aa)
CDCA7Uncharacterized protein. (264 aa)
HEXABeta-hexosaminidase. (631 aa)
TSPO2Translocator protein 2. (190 aa)
PLIN2Perilipin; Belongs to the perilipin family. (446 aa)
SPOUT1Uncharacterized protein. (470 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (464 aa)
PMLLUncharacterized protein. (464 aa)
SUN1Sad1 and UNC84 domain containing 1. (906 aa)
CD4Uncharacterized protein. (487 aa)
NFKBIBNFKB inhibitor beta. (320 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
LOC770839SUN domain-containing protein. (306 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
ENSGALP00000066836ANK_REP_REGION domain-containing protein. (202 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein; Plays a role as an effector of the ADP-ribosylation factor- like protein 2, ARL2; Belongs to the ARL2BP family. (156 aa)
CIZ1C2H2-type domain-containing protein. (651 aa)
IGSF11Uncharacterized protein. (445 aa)
FFAR2LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (367 aa)
TSPOUncharacterized protein. (516 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
ENSGALP00000068920SUN domain-containing protein 3-like isoform X1. (182 aa)
PNPLA3Patatin like phospholipase domain containing 3. (543 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3587 aa)
STARD4START domain-containing protein. (224 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
LOC107050658Free fatty acid receptor 2-like. (367 aa)
TMEM159-2Uncharacterized protein. (103 aa)
ANKRD13CUncharacterized protein. (152 aa)
TMSB4YThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
LDAHLipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Belongs to the AB hydrolase superfamily. LDAH family. (377 aa)
ARHGAP21Uncharacterized protein. (1998 aa)
LOC776146SUN domain-containing protein. (275 aa)
FITM2Fat storage inducing transmembrane protein 2. (396 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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