STRINGSTRING
TP73 TP73 SAMHD1 SAMHD1 TSHB TSHB CRTC1 CRTC1 ALDH9A1 ALDH9A1 THG1L THG1L TRPM1 TRPM1 KCNJ2 KCNJ2 KCNJ12 KCNJ12 FARSB FARSB TRPM2 TRPM2 PKD1 PKD1 PKD2L1 PKD2L1 UPB1 UPB1 EVL EVL CRYZ CRYZ SOD2 SOD2 CBY1 CBY1 SSBP1 SSBP1 TRPV6 TRPV6 TTR TTR TRPM6 TRPM6 USP16 USP16 RRM1 RRM1 TRPM7 TRPM7 APPL2 APPL2 TDO2 TDO2 SHMT1 SHMT1 PKD2 PKD2 GNMT GNMT CPSF6 CPSF6 AQP5 AQP5 AQP2 AQP2 MIP MIP TRPM3 TRPM3 STK4 STK4 HSD17B10 HSD17B10 STK3 STK3 TK1 TK1 CUTC CUTC TRPA1 TRPA1 CPSF7 CPSF7 APIP APIP ALDH1A3 ALDH1A3 FARSA FARSA HOMER1 HOMER1 CBR4 CBR4 ALDH1A2 ALDH1A2 TP63 TP63 ACOT13 ACOT13 OSBPL2 OSBPL2 CRTC2 CRTC2 ENSGALP00000070455 ENSGALP00000070455 LOC112530325 LOC112530325 NUDT21 NUDT21 AQP4 AQP4 ENSGALP00000073444 ENSGALP00000073444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] (614 aa)
TSHBThyrotropin subunit beta. (210 aa)
CRTC1CREB regulated transcription coactivator 1. (620 aa)
ALDH9A1Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family. (579 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (294 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1625 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions. (429 aa)
FARSBB5 domain-containing protein. (589 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4382 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (746 aa)
UPB1Beta-ureidopropionase 1. (383 aa)
EVLWH1 domain-containing protein. (418 aa)
CRYZPKS_ER domain-containing protein. (331 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
CBY1Uncharacterized protein. (126 aa)
SSBP1Uncharacterized protein. (149 aa)
TRPV6ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (724 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (168 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (2034 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (818 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
TRPM7Alpha-type protein kinase domain-containing protein. (1868 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (478 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
PKD2Uncharacterized protein. (881 aa)
GNMTMethyltransf_25 domain-containing protein. (172 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (582 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
AQP2Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (275 aa)
MIPLens fiber major intrinsic protein; Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
TRPM3Transient receptor potential cation channel subfamily M member 3. (1689 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (504 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (418 aa)
STK3Uncharacterized protein. (490 aa)
TK1Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. (224 aa)
CUTCCutC domain-containing protein. (491 aa)
TRPA1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1126 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (533 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (242 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
FARSAPhenylalanine--tRNA ligase alpha subunit. (569 aa)
HOMER1Homer scaffold protein 1. (358 aa)
CBR4Carbonyl reductase 4. (247 aa)
ALDH1A2Retinal dehydrogenase 2; Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral. (499 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ACOT13Acyl-CoA thioesterase 13. (143 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (481 aa)
CRTC2TORC_N domain-containing protein. (320 aa)
ENSGALP00000070455Uncharacterized protein. (124 aa)
LOC112530325Uncharacterized protein. (58 aa)
NUDT21Nudix hydrolase domain-containing protein. (473 aa)
AQP4Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (417 aa)
ENSGALP00000073444Uncharacterized protein. (67 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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