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| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1363 aa) |
| | AKAP5 | Uncharacterized protein. (596 aa) |
| | CMTM6 | CKLF like MARVEL transmembrane domain containing 6. (183 aa) |
| | KCNK1 | Potassium channel subfamily K member. (336 aa) |
| | RNF11 | RING-type domain-containing protein. (154 aa) |
| | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (497 aa) |
| | SLC1A1 | Amino acid transporter. (527 aa) |
| | CLCN3 | Chloride channel protein. (866 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | INPP5F | Inositol polyphosphate-5-phosphatase F. (1126 aa) |
| | EHD3 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa) |
| | COMMD1 | Copper metabolism domain containing 1. (215 aa) |
| | TUBGCP4 | Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (665 aa) |
| | TPCN1 | Two pore segment channel 1. (817 aa) |
| | GGA3 | Uncharacterized protein. (754 aa) |
| | RAB11A | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). (216 aa) |
| | ST8SIA2 | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (375 aa) |
| | LOC416959 | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | TF | Ovotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa) |
| | ABHD17C | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Belongs to the AB hydrolase superfamily. ABHD17 family. (310 aa) |
| | SLC9A6 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (866 aa) |
| | ACKR2 | Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (290 aa) |
| | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2. (1792 aa) |
| | MICALL2 | Uncharacterized protein. (629 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | UNC13D | Unc-13 homolog D. (708 aa) |
| | SCAMP2 | Secretory carrier-associated membrane protein. (333 aa) |
| | RAB14 | Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (144 aa) |
| | STX12 | Syntaxin 12; Belongs to the syntaxin family. (272 aa) |
| | RAB29 | RAB29, member RAS oncogene family. (205 aa) |
| | RAB11B | Uncharacterized protein. (218 aa) |
| | ATG9A | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa) |
| | ATP11C | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1265 aa) |
| | NEU2 | Neuraminidase 2. (413 aa) |
| | ENSGALP00000066581 | Uncharacterized protein. (532 aa) |
| | WASH1 | WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa) |
| | C1orf210 | Chromosome 1 open reading frame 210. (119 aa) |
| | MICALL1 | Uncharacterized protein. (991 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1283 aa) |
| | ATP11A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1174 aa) |
| | RAB11FIP3 | RAB11 family interacting protein 3. (689 aa) |
| | SGK3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa) |
| | LOC101747255 | Uncharacterized protein. (368 aa) |
| | ATG9B | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa) |
| | GRIPAP1 | Uncharacterized protein. (764 aa) |
| | SCAMP3 | Uncharacterized protein. (459 aa) |
| | PLEKHB2 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes. (232 aa) |
| | RAB11FIP1 | RAB11 family interacting protein 1. (1259 aa) |
| | ACKR4 | Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (385 aa) |
| | VPS50 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. (997 aa) |
| | NISCH | Nischarin. (1415 aa) |
| | FCHSD1 | FCH and double SH3 domains 1. (788 aa) |
| | RAB11FIP4 | RAB11 family interacting protein 4. (496 aa) |
| | SCAMP5 | Secretory carrier-associated membrane protein. (235 aa) |
| | SLC26A7 | Anion exchange transporter. (658 aa) |
| | AMOTL2 | Angiomotin like 2. (717 aa) |
| | RAB4A | RAB4A, member RAS oncogene family. (255 aa) |
| | TPCN3 | Uncharacterized protein. (783 aa) |
| | EHD2 | EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | ENSGALP00000073670 | Uncharacterized protein. (184 aa) |
| | SORCS2 | Sortilin related VPS10 domain containing receptor 2. (1169 aa) |
| | SCAMP4 | Secretory carrier-associated membrane protein. (229 aa) |
| | VPS33B | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa) |
| | NEU3 | Sialidase domain-containing protein. (636 aa) |
| | RAB10L | Uncharacterized protein. (208 aa) |
| | SCAMP1 | Secretory carrier-associated membrane protein. (481 aa) |
| | SYT11 | Synaptotagmin 11. (432 aa) |
| | LAMP5 | Lysosomal associated membrane protein family member 5. (344 aa) |
| | SDCCAG3 | Uncharacterized protein. (135 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | RABEP1 | Uncharacterized protein. (782 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (838 aa) |
| | SLC31A1 | Uncharacterized protein. (214 aa) |
| | FCHSD2 | FCH and double SH3 domains 2. (1105 aa) |
| | STX7 | t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa) |
| | RAP2B | RAP2B, member of RAS oncogene family. (118 aa) |
| | RAN | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | RAB2B | Uncharacterized protein. (428 aa) |
| | GRIA1 | Uncharacterized protein. (902 aa) |
| | MLC1 | Modulator of VRAC current 1. (379 aa) |
| | STX8 | t-SNARE coiled-coil homology domain-containing protein. (273 aa) |
| | FZD7 | Frizzled-7; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (567 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | PHETA1 | PH domain containing endocytic trafficking adaptor 1. (238 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] (330 aa) |
| | ABHD17A | Abhydrolase domain containing 17A. (304 aa) |
| | TBC1D12 | TBC1 domain family member 12. (779 aa) |
| | MCOLN2 | Mucolipin 2. (598 aa) |
| | RAB25 | RAB25, member RAS oncogene family. (209 aa) |
| | INPP4A | Inositol polyphosphate-4-phosphatase type I A. (983 aa) |
| | ITSN1 | Intersectin 1. (1696 aa) |
| | SLC31A2 | Solute carrier family 31 member 2. (239 aa) |
| | TPP1 | Tripeptidyl peptidase 1. (575 aa) |
| | SORL1 | Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...] (2205 aa) |
| | LZTR1 | Leucine zipper like transcription regulator 1. (786 aa) |
| | AVL9 | AVL9 cell migration associated. (644 aa) |
| | VPS53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling. (831 aa) |
| | SLC9A7 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa) |
| | RAB12 | RAB12, member RAS oncogene family. (290 aa) |
| | DENND6A | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Belongs to the DENND6 family. (584 aa) |
| | DENND6B | DENN domain containing 6B. (542 aa) |
| | LOC100859020 | Uncharacterized protein. (397 aa) |
| | CXCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. (413 aa) |
| | RASSF9 | Ras association domain family member 9. (440 aa) |
| | ARF6 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa) |
| | SLC30A10 | Solute carrier family 30 member 10. (232 aa) |
| | PLEKHJ1 | Pleckstrin homology domain-containing family J member 1. (149 aa) |
| | SLC9A9 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (642 aa) |
| | VPS51 | Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (787 aa) |
| | RAP2C | Uncharacterized protein. (183 aa) |
| | ATP11B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1148 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | RAB10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa) |
| | VAMP3 | V-SNARE coiled-coil homology domain-containing protein. (104 aa) |
| | MELTF | Ovotransferrin; Belongs to the transferrin family. (738 aa) |
| | RAP2A | RAP2A, member of RAS oncogene family. (183 aa) |
| | SH3TC1 | SH3 domain and tetratricopeptide repeats 1. (1341 aa) |
| | TBC1D14 | Rab-GAP TBC domain-containing protein. (711 aa) |
| | GPR161 | G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (535 aa) |
| | CD274 | Uncharacterized protein. (471 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Belongs to the NSG family. (185 aa) |
| | PLA2G5 | Phospholipase A(2). (158 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa) |
| | OPTN | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. (557 aa) |
| | NTRK1 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa) |
| | PHETA2 | PH domain containing endocytic trafficking adaptor 2. (252 aa) |
