STRINGSTRING
RAB20 RAB20 ATP4B ATP4B SLC9A2 SLC9A2 RHAG RHAG TMPRSS3 TMPRSS3 ATP6AP1L ATP6AP1L GPR89A GPR89A TMEM175 TMEM175 UPK3A UPK3A RHBG RHBG BCL2 BCL2 EDN1 EDN1 SLC12A8 SLC12A8 SLC4A3 SLC4A3 EDNRA EDNRA ATP6AP1 ATP6AP1 SLC9A8 SLC9A8 CLN6 CLN6 SLC9A5 SLC9A5 LOC422276 LOC422276 RHCG RHCG TM9SF4 TM9SF4 ATP12A ATP12A SCNN1B SCNN1B SLC9A6 SLC9A6 SLC12A1 SLC12A1 SLC9A3 SLC9A3 TCIRG1 TCIRG1 PPT1 PPT1 ATP6V0A2 ATP6V0A2 KCTD7 KCTD7 ATP6V0D1 ATP6V0D1 CLIC4 CLIC4 SCNN1D SCNN1D SLC12A4 SLC12A4 ENSGALP00000067557 ENSGALP00000067557 DMXL1 DMXL1 ENSGALP00000067896 ENSGALP00000067896 LOC107049680 LOC107049680 SLC4A2 SLC4A2 ENSGALP00000070886 ENSGALP00000070886 LACC1 LACC1 SLC9A1 SLC9A1 KCNQ1 KCNQ1 EDNRB2 EDNRB2 ATP1B3 ATP1B3 SLC4A7 SLC4A7 ENSGALP00000073501 ENSGALP00000073501 RNASEK RNASEK SLC1A3 SLC1A3 SCNN1A SCNN1A ATP6V0A1 ATP6V0A1 EXT2 EXT2 SLC12A7 SLC12A7 CA7 CA7 SLC12A9 SLC12A9 SLC4A8 SLC4A8 CFTR CFTR ATP6V0A4 ATP6V0A4 ATP6V0D2 ATP6V0D2 SLC4A5 SLC4A5 LRRK2 LRRK2 AQP11 AQP11 GRN GRN ATP6V1B2 ATP6V1B2 SCNN1G SCNN1G CA2 CA2 ATP1A1 ATP1A1 TMEM106B TMEM106B RHCE RHCE SLC4A9 SLC4A9 VPS33A VPS33A CXorf21 CXorf21 TMEM165 TMEM165 RAB7A RAB7A UBE3A UBE3A LOC101750621 LOC101750621 SLC26A4 SLC26A4 TMEM9 TMEM9 SLC4A1 SLC4A1 SLC9A7 SLC9A7 SLC4A10 SLC4A10 SLC4A4 SLC4A4 SLC12A5 SLC12A5 MC3R MC3R SLC26A6 SLC26A6 SNAPIN SNAPIN SLC9A9 SLC9A9 SLC12A2 SLC12A2 ATP1B1 ATP1B1 ATP6AP2 ATP6AP2 EDNRB EDNRB CHP1 CHP1 SLC26A3 SLC26A3 RAB39A RAB39A
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB20RAB20, member RAS oncogene family. (163 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (299 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (806 aa)
RHAGAmmonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (406 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (470 aa)
ATP6AP1LATPase H+ transporting accessory protein 1 like. (356 aa)
GPR89AGolgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. (455 aa)
TMEM175Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel; Belongs to the TMEM175 family. (501 aa)
UPK3AUroplakin 3A. (264 aa)
RHBGAmmonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (451 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
EDN1Endothelin 1. (194 aa)
SLC12A8AA_permease domain-containing protein. (468 aa)
SLC4A3Anion exchange protein. (1249 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
ATP6AP1Uncharacterized protein. (455 aa)
SLC9A8Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity); Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (645 aa)
CLN6Uncharacterized protein. (317 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (909 aa)
LOC422276Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (668 aa)
RHCGAmmonium transporter Rh type C; Functions as an ammonia transporter. (467 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (668 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1033 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (667 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (866 aa)
SLC12A1Solute carrier family 12 member 1. (1097 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (830 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
PPT1Uncharacterized protein. (300 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
KCTD7BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons. (289 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
CLIC4Chloride intracellular channel 4. (253 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
SLC12A4Solute carrier family 12 member 4. (1160 aa)
ENSGALP00000067557Uncharacterized protein. (239 aa)
DMXL1Dmx like 1. (3057 aa)
ENSGALP00000067896Uncharacterized protein. (105 aa)
LOC107049680ATP-synt_ab domain-containing protein. (721 aa)
SLC4A2Anion exchange protein. (1411 aa)
ENSGALP00000070886AA_permease domain-containing protein. (143 aa)
LACC1Uncharacterized protein. (438 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (850 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
EDNRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known; Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa)
SLC4A7Anion exchange protein. (1243 aa)
ENSGALP00000073501Uncharacterized protein. (458 aa)
RNASEKRibonuclease K. (130 aa)
SLC1A3Amino acid transporter. (543 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. (612 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (863 aa)
EXT2Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (717 aa)
SLC12A7Uncharacterized protein. (1125 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (259 aa)
SLC12A9Uncharacterized protein. (897 aa)
SLC4A8Anion exchange protein. (1068 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (842 aa)
ATP6V0D2V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
SLC4A5Anion exchange protein. (1060 aa)
LRRK2Uncharacterized protein. (2557 aa)
AQP11Aquaporin 11; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
GRNUncharacterized protein. (287 aa)
ATP6V1B2V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (503 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
CA2Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. (260 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. (1021 aa)
TMEM106BUncharacterized protein. (278 aa)
RHCEAmmonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (397 aa)
SLC4A9Anion exchange protein. (929 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
CXorf21Chromosome X open reading frame 21. (289 aa)
TMEM165GDT1 family protein. (322 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
LOC101750621Uncharacterized protein. (332 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (816 aa)
TMEM9Transmembrane protein 9A. (191 aa)
SLC4A1Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride- bicarbonate exch [...] (923 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
SLC4A10Anion exchange protein. (1116 aa)
SLC4A4Anion exchange protein. (1113 aa)
SLC12A5Solute carrier family 12 member 5. (1130 aa)
MC3RMelanocortin 3 receptor. (325 aa)
SLC26A6STAS domain-containing protein. (752 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (642 aa)
SLC12A2Solute carrier family 12 member 2. (1150 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (305 aa)
ATP6AP2Uncharacterized protein. (354 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa)
RAB39ARAB39A, member RAS oncogene family. (216 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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