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| | SEMA3DL | Ig-like domain-containing protein. (165 aa) |
| | HOMER3 | Sema domain-containing protein; Belongs to the semaphorin family. (763 aa) |
| | LRRC45 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. (670 aa) |
| | RND2 | Uncharacterized protein. (227 aa) |
| | FRZB | Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa) |
| | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). (558 aa) |
| | NOTCH1 | Uncharacterized protein. (2561 aa) |
| | SEMA6A | Semaphorin-6A isoform4; Belongs to the semaphorin family. (1044 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa) |
| | PROC | Uncharacterized protein. (433 aa) |
| | NPTN | Uncharacterized protein. (397 aa) |
| | C1QBP | Complement C1q binding protein. (214 aa) |
| | SEMA3G | Semaphorin 3G; Belongs to the semaphorin family. (761 aa) |
| | CLDN5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa) |
| | SEMA7A | Sema domain-containing protein; Belongs to the semaphorin family. (636 aa) |
| | PLXNA2 | Plexin A2. (1893 aa) |
| | SKI | Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity). (750 aa) |
| | HES5 | Hairy and enhancer of split 5. (157 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (781 aa) |
| | TTPAL | CRAL-TRIO domain-containing protein. (339 aa) |
| | DLX1 | Homeodomain transcription factor DLX1. (255 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa) |
| | OCM | Parvalbumin, thymic CPV3; Binds two calcium ions. (109 aa) |
| | MAPT | Microtubule-associated protein. (788 aa) |
| | AMIGO1 | Adhesion molecule with Ig like domain 1. (492 aa) |
| | HOXC11 | Homeobox C11. (193 aa) |
| | ENSGALP00000073564 | Uncharacterized protein. (243 aa) |
| | SPART | Spartin. (631 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa) |
| | S1PR2 | Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa) |
| | MAP2 | Microtubule-associated protein. (1955 aa) |
| | ZNF365 | Uncharacterized protein. (403 aa) |
| | PLXNC1 | Plexin C1. (1279 aa) |
| | LIMS2 | LIM zinc finger domain containing 2. (252 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa) |
| | EDNRB2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa) |
| | NF2L | FERM domain-containing protein. (648 aa) |
| | LOC107050371 | Uncharacterized protein. (1015 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | MYF6 | Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. (341 aa) |
| | BHLHE41 | Basic helix-loop-helix family member e41. (440 aa) |
| | MECP2 | Methyl-CpG binding protein 2. (208 aa) |
| | HEYL | Hes related family bHLH transcription factor with YRPW motif like. (319 aa) |
| | ENSGALP00000069955 | Uncharacterized protein. (496 aa) |
| | FAIM | Fas apoptotic inhibitory molecule. (179 aa) |
| | TRAK1 | Trafficking kinesin protein 1. (1048 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (678 aa) |
| | LOC107056280 | Uncharacterized protein. (466 aa) |
| | PLXNA1 | Plexin A1. (1903 aa) |
| | HELT | Helt bHLH transcription factor. (240 aa) |
| | PTHLH | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa) |
| | NTRK2 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa) |
| | CDK5 | Protein kinase domain-containing protein. (522 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (488 aa) |
| | ENSGALP00000068660 | Uncharacterized protein. (221 aa) |
| | PLXND1 | Plexin D1. (1928 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa) |
| | DIP2B | Disco interacting protein 2 homolog B. (1572 aa) |
| | FBXW9 | F-box domain-containing protein. (337 aa) |
| | CDKL5 | Cyclin dependent kinase like 5. (1024 aa) |
| | DAAM1 | Uncharacterized protein. (1100 aa) |
| | HES6 | Hes family bHLH transcription factor 6. (242 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa) |
| | METRN | Meteorin, glial cell differentiation regulator. (294 aa) |
| | SEMA6B | Sema domain-containing protein; Belongs to the semaphorin family. (870 aa) |
| | REST | Uncharacterized protein. (339 aa) |
| | SEMA5A | Semaphorin 5A. (1076 aa) |
| | PLAG1 | Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa) |
| | PLXNB2 | Plexin B2. (1781 aa) |
| | LDLR | Uncharacterized protein. (302 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (826 aa) |
| | PLXNB3 | Sema domain-containing protein. (2202 aa) |
| | SEMA4C | Semaphorin 4C; Belongs to the semaphorin family. (1080 aa) |
| | DBNL | ADF-H domain-containing protein. (124 aa) |
| | SEMA3C | Semaphorin-3C; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (751 aa) |
| | DMTN | AbLIM_anchor domain-containing protein. (687 aa) |
| | SEMA6D | Semaphorin 6D; Belongs to the semaphorin family. (1088 aa) |
| | HES2 | Hes family bHLH transcription factor 2. (99 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (356 aa) |
| | DIXDC1 | DIX domain containing 1. (689 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa) |
| | LOC112530215 | Sema domain-containing protein; Belongs to the semaphorin family. (606 aa) |
| | CAPRIN2 | Caprin family member 2. (1267 aa) |
| | ENSGALP00000064942 | Uncharacterized protein. (152 aa) |
| | ENSGALP00000062901 | Uncharacterized protein. (229 aa) |
| | TNR | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. (1353 aa) |
| | NEFL | Neurofilament light; Belongs to the intermediate filament family. (373 aa) |
| | KIFAP3 | Kinesin associated protein 3. (793 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | ENSGALP00000060974 | LIM zinc-binding domain-containing protein. (209 aa) |
| | ENSGALP00000060823 | Ig-like domain-containing protein. (511 aa) |
| | SEMA6C | Semaphorin 6C; Belongs to the semaphorin family. (837 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa) |
| | IST1 | IST1 factor associated with ESCRT-III. (366 aa) |
| | ENSGALP00000058848 | Uncharacterized protein. (236 aa) |
| | HES4 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). (290 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa) |
| | RNF10 | Ring finger protein 10. (803 aa) |
| | TTPA | Alpha tocopherol transfer protein. (277 aa) |
| | SHTN1 | Shootin 1. (649 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa) |
| | TESK1 | Testis associated actin remodelling kinase 1. (736 aa) |
| | PTPRF | Protein tyrosine phosphatase receptor type F. (1936 aa) |
| | DBN1 | Drebrin; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in synaptic plasticity (By similarity). (652 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (335 aa) |
| | NKX6-1 | NK6 homeobox 1. (272 aa) |
| | PRTG | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. (1187 aa) |
| | CHD7 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa) |
| | SMAD7B | Mothers against decapentaplegic homolog. (388 aa) |
| | RECK | Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (By similarity). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to del [...] (963 aa) |
| | TMEM98 | Transmembrane protein 98. (222 aa) |
| | TNFRSF1B | Uncharacterized protein. (462 aa) |
| | PTPRS | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for norm [...] (1924 aa) |
| | SERPINF1 | SERPIN domain-containing protein; Belongs to the serpin family. (416 aa) |
| | ENSGALP00000055781 | Cullin_Nedd8 domain-containing protein. (146 aa) |
| | SEMA3B | Semaphorin 3B. (608 aa) |
| | TNFRSF8 | TNFR-Cys domain-containing protein. (467 aa) |
| | SPRY4 | Sprouty RTK signaling antagonist 4. (430 aa) |
| | ZNF335 | Uncharacterized protein. (1473 aa) |
| | PTPRZ1 | Protein-tyrosine-phosphatase. (2343 aa) |
| | PRUNE1 | Prune exopolyphosphatase 1. (521 aa) |
| | SEMA5B | Semaphorin 5B. (1150 aa) |
| | FOXG1 | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa) |
| | SRF | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (388 aa) |
| | GRN | Uncharacterized protein. (287 aa) |
| | FBXO22 | FIST_C domain-containing protein. (393 aa) |
| | TIAM2 | Uncharacterized protein. (1705 aa) |
| | BCL11A | Uncharacterized protein. (796 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (392 aa) |
| | SLC7A5 | Large neutral amino acids transporter small subunit 1. (526 aa) |
| | LRP4 | LDL receptor related protein 4. (1911 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa) |
| | TENM4 | Uncharacterized protein. (2766 aa) |
| | LRRK2 | Uncharacterized protein. (2557 aa) |
| | DLX2 | Distal-less homeobox 2. (253 aa) |
| | DHX36 | DEAH-box helicase 36. (987 aa) |
| | ID1 | Helix-loop-helix protein. (118 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1081 aa) |
| | PTPRD | Protein tyrosine phosphatase receptor type D. (1963 aa) |
| | IKBKB | Protein kinase domain-containing protein. (753 aa) |
| | SDC3 | Syndecan-3; Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage [...] (405 aa) |
| | SEMA3E | Semaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity); Belongs to the se [...] (779 aa) |
| | RAPGEF2 | Rap guanine nucleotide exchange factor 2. (1652 aa) |
| | FBXW7 | Uncharacterized protein. (586 aa) |
| | SYT4 | Synaptotagmin 4. (425 aa) |
| | HOXB3 | Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (399 aa) |
| | IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity). (431 aa) |
| | GSX2 | GS homeobox 2. (263 aa) |
| | TNFRSF1A | Uncharacterized protein. (427 aa) |
| | SMO | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa) |
| | ILK | Integrin-linked kinase. (452 aa) |
| | ASCL2 | Achaete-scute family bHLH transcription factor 2. (167 aa) |
| | MTOR | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa) |
| | DAB2 | DAB adaptor protein 2. (715 aa) |
| | DISC1 | DISC1 scaffold protein. (856 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa) |
| | ENSGALP00000048186 | Uncharacterized protein. (528 aa) |
| | LIMS1 | LIM domain-containing protein. (362 aa) |
| | ASCL1 | BHLH domain-containing protein. (219 aa) |
| | OLIG2 | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2820 aa) |
| | LYN | Tyrosine-protein kinase. (491 aa) |
| | POU4F1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa) |
| | SPEN | Spen family transcriptional repressor. (3583 aa) |
| | BAIAP2 | BAI1 associated protein 2. (573 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1594 aa) |
| | HOXA11 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (529 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | SLIT2 | Uncharacterized protein. (1533 aa) |
| | SEMA3F | Sema domain-containing protein; Belongs to the semaphorin family. (838 aa) |
| | WNT2B | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa) |
| | GOLGA4 | Golgin A4. (2285 aa) |
| | CHTOP | Mothers against decapentaplegic homolog. (445 aa) |
| | SIRT2 | Deacetylase sirtuin-type domain-containing protein. (485 aa) |
| | ENSGALP00000044096 | Uncharacterized protein. (239 aa) |
| | NUMB | PID domain-containing protein. (620 aa) |
| | FZD3 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa) |
| | SYNJ1 | Synaptojanin 1. (1536 aa) |
| | MYF5 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa) |
| | ANKRD27 | Uncharacterized protein. (1087 aa) |
| | ISLR2 | Ig-like domain-containing protein. (699 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. (413 aa) |
| | HES6-2 | Uncharacterized protein. (227 aa) |
| | SEMA3A | Semaphorin-3A; Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to neuropilin; Belongs to the semaphorin family. (815 aa) |
| | HES1 | Transcription factor HES-1. (257 aa) |
| | IL34 | Interleukin 34. (178 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | METRNL | Meteorin like, glial cell differentiation regulator. (292 aa) |
| | LOC107057363 | Uncharacterized protein. (197 aa) |
| | OTP | Orthopedia homeobox. (325 aa) |
| | CX3CL1 | SCY domain-containing protein. (496 aa) |
| | SEMA4G | Semaphorin 4G; Belongs to the semaphorin family. (841 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (301 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | ZDHHC21 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa) |
| | TNFSF11 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa) |
| | THY1 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa) |
| | MYOG | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (227 aa) |
| | HAP1 | Uncharacterized protein. (851 aa) |
| | RFLNA | Refilin A. (212 aa) |
| | MYOD1 | Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa) |
| | DAAM2 | Disheveled-associated activator of morphogenesis 2; Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal [...] (1187 aa) |
| | SEMA4D | Semaphorin-4D; Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). (855 aa) |
| | LOC430303 | Uncharacterized protein. (2034 aa) |
| | DCT | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa) |
| | EDNRB | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa) |
| | LOC419390 | Uncharacterized protein. (161 aa) |
| | ISLR | Immunoglobulin superfamily containing leucine rich repeat. (422 aa) |
| | MYOC | Myocilin. (467 aa) |
| | NF2 | FERM domain-containing protein. (595 aa) |
| | DYNLT1 | Dynein light chain Tctex-type 1. (125 aa) |
| | LOC419074 | Uncharacterized protein. (765 aa) |
| | OLFM4 | Olfactomedin-like domain-containing protein. (489 aa) |
| | SLITRK1 | SLIT and NTRK like family member 1. (692 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa) |
| | ITGB1BP1 | PID domain-containing protein. (208 aa) |
| | DSCAM | Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (2034 aa) |
| | CHODL | Chondrolectin. (291 aa) |
| | ADD1 | Aldolase_II domain-containing protein. (736 aa) |
| | HOOK3 | Hook microtubule tethering protein 3. (713 aa) |
| | IL6ST | Glycoprotein 130. (918 aa) |
| | OPRM1 | Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (415 aa) |
| | CAPRIN1 | Cytoplasmic activation-proliferation-associated protein 1. (702 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | NIN | Ninein. (2081 aa) |
| | RUFY3 | RUN and FYVE domain containing 3. (667 aa) |
| | IHH | Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa) |
| | NKX6-2 | Homeobox domain-containing protein. (364 aa) |
| | FERD3L | Fer3 like bHLH transcription factor. (150 aa) |
| | LRP2 | LDL receptor related protein 2. (3187 aa) |
| | HDAC9 | Histone deacetylase 9; Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2- dependent transcription (By similarity). (761 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antige [...] (207 aa) |
| | LRP8 | Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa) |
| | SNW1 | SNW domain containing 1. (538 aa) |
| | AMIGO2 | Ig-like domain-containing protein. (521 aa) |
| | DUSP10 | Uncharacterized protein. (478 aa) |
| | IFRD1 | Uncharacterized protein. (434 aa) |
| | VAX1 | Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa) |
| | FEZF1 | FEZ family zinc finger 1. (438 aa) |
| | NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa) |
| | SPINT1 | Uncharacterized protein. (509 aa) |
| | F2 | Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa) |
| | CIB4 | Uncharacterized protein. (190 aa) |
| | SEMA4B | Semaphorin 4B; Belongs to the semaphorin family. (861 aa) |
| | NEURL1 | Uncharacterized protein. (555 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (582 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1210 aa) |
| | DRD2 | Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa) |
| | CASS4 | Cas scaffold protein family member 4. (838 aa) |
| | RTN4R | Reticulon 4 receptor. (483 aa) |
| | MAP6 | Microtubule-associated protein 6 homolog; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (By similarity). (369 aa) |
| | APOA1 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa) |
| | EEF2K | Eukaryotic elongation factor 2 kinase. (742 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (358 aa) |
| | DNAJB11 | J domain-containing protein. (373 aa) |
| | SEMA3D | Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (761 aa) |
| | RYK | Receptor like tyrosine kinase. (481 aa) |
| | PLXNA4 | Plexin A4. (1892 aa) |
| | JADE2 | Jade family PHD finger 2. (922 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (193 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | ABCC8 | ATP binding cassette subfamily C member 8. (1595 aa) |
| | BNC1 | Basonuclin 1. (759 aa) |
| | PAFAH1B1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | SOX8 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (442 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | VCL | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa) |
| | FBN1 | Fibrillin 1. (2861 aa) |
| | RFLNB | Refilin B. (208 aa) |
| | ULK2 | Unc-51 like autophagy activating kinase 2. (1001 aa) |
| | ASPA | Aspartoacylase. (361 aa) |
| | CUX2 | Homeobox protein cut-like. (1386 aa) |
| | TRPV2 | Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (785 aa) |
