STRINGSTRING
LEF1 LEF1 COL1A1 COL1A1 STRA6 STRA6 BBS4 BBS4 MMP2 MMP2 LOC427439 LOC427439 DKK1 DKK1 MKKS MKKS DLX5 DLX5 EDNRA EDNRA TGFBR2 TGFBR2 EP300 EP300 RAB3GAP1 RAB3GAP1 MSX1 MSX1 ZFAND5 ZFAND5 TGFB3 TGFB3 CSRNP1 CSRNP1 ASPH-2 ASPH-2 CHD9 CHD9 ENSGALP00000048186 ENSGALP00000048186 CRISPLD1 CRISPLD1 HOXB3 HOXB3 LOC427025 LOC427025 SRF SRF ALDH1A3 ALDH1A3 CHD7 CHD7 LOC426626 LOC426626 ENSGALP00000069955 ENSGALP00000069955 SGPL1 SGPL1 LOC107050371 LOC107050371 WNT11 WNT11 CRISPLD2 CRISPLD2 ANKRD11 ANKRD11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1HMG box domain-containing protein. (412 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
STRA6Uncharacterized protein. (671 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
LOC427439Nipped-B protein. (2783 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (240 aa)
MKKSUncharacterized protein. (570 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
EP300E1A binding protein p300. (2450 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
ZFAND5Uncharacterized protein. (334 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (469 aa)
ASPH-2Asp-B-Hydro_N domain-containing protein. (350 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
CRISPLD1Cysteine-rich secretory protein LCCL domain-containing 1. (513 aa)
HOXB3Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (399 aa)
LOC427025Nipped-B protein. (2769 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
LOC426626Uncharacterized protein. (228 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
SGPL1Uncharacterized protein. (574 aa)
LOC107050371Uncharacterized protein. (1015 aa)
WNT11Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
CRISPLD2Cysteine rich secretory protein LCCL domain containing 2. (503 aa)
ANKRD11Ankyrin repeat domain 11. (2707 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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