STRINGSTRING
ENSGALP00000072609 ENSGALP00000072609 ANKRD11 ANKRD11 GP1BB GP1BB PTPN6 PTPN6 LOC100857622 LOC100857622 HOXC11 HOXC11 TSKU TSKU SPNS2 SPNS2 MED1 MED1 NOTUM NOTUM HOMER3 HOMER3 SRC SRC IFITM5 IFITM5 NPPC-2 NPPC-2 SULF2 SULF2 SH2B3 SH2B3 P3H1 P3H1 TMEM119 TMEM119 GP9 GP9 FREM1 FREM1 CER1 CER1 PAFAH1B1 PAFAH1B1 SHH SHH AKAP13 AKAP13 LRRK1 LRRK1 FGF4 FGF4 ADAMTS7 ADAMTS7 DDR1 DDR1 ABI1 ABI1 ATP6AP1 ATP6AP1 DLX5 DLX5 IFT80 IFT80 TRIP11 TRIP11 SNX10 SNX10 ITGB6 ITGB6 EPYC EPYC IHH IHH TGFBR2 TGFBR2 EP300 EP300 BMP6 BMP6 PEX7 PEX7 TRIM45 TRIM45 MSX1 MSX1 EVC EVC WHSC1-2 WHSC1-2 RIPPLY2 RIPPLY2 CYP26B1 CYP26B1 IFT172 IFT172 MMP13 MMP13 CHAD CHAD LEPR LEPR PHOSPHO2 PHOSPHO2 FGF8 FGF8 MYOC MYOC BMPR1B BMPR1B SEMA4D SEMA4D SOX9 SOX9 ALPL ALPL TGM2 TGM2 AMER1 AMER1 TNFSF11 TNFSF11 TMEM38B TMEM38B OGN OGN FAM20C FAM20C GLG1 GLG1 ENSGALP00000044025 ENSGALP00000044025 SH3PXD2B SH3PXD2B IMPAD1 IMPAD1 MEF2D MEF2D RAB23 RAB23 HOXA11 HOXA11 SP5 SP5 PITX2 PITX2 EXT2 EXT2 OSTN OSTN FOXN3 FOXN3 ZBTB32 ZBTB32 ANXA2P2 ANXA2P2 CTC1 CTC1 BNC2 BNC2 SMAD1 SMAD1 DDR2 DDR2 FLI1 FLI1 TTC9 TTC9 KIT KIT SDC3 SDC3 PHOSPHO1 PHOSPHO1 MIGA2 MIGA2 MAPK14 MAPK14 SRF SRF FGF18 FGF18 SULF1 SULF1 PTPRC PTPRC BGLAP BGLAP MAPK11 MAPK11 ANXA6 ANXA6 COL1A1 COL1A1 BMPR2 BMPR2 WISP1 WISP1 DHRS3 DHRS3 RPL13 RPL13 MCPH1 MCPH1 ZNF385A ZNF385A VPS33B VPS33B NPPC NPPC FAM20CL FAM20CL ADAMTS12 ADAMTS12 ATG9A ATG9A SLC10A7 SLC10A7 WHSC1 WHSC1 SLC38A10 SLC38A10 MBTPS2 MBTPS2 ZFPM1 ZFPM1 RANBP3L RANBP3L ENSGALP00000068281 ENSGALP00000068281 LRRC17 LRRC17 LOC101750889 LOC101750889 ATG9B ATG9B INPPL1 INPPL1 NAB2 NAB2 PHEX PHEX TMEM107 TMEM107 WASF2 WASF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGALP00000072609Uncharacterized protein. (215 aa)
ANKRD11Ankyrin repeat domain 11. (2707 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (202 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa)
LOC100857622EXPERA domain-containing protein. (218 aa)
HOXC11Homeobox C11. (193 aa)
TSKUTsukushin; Dorsalizing factor involved in the induction of Hensen node. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (369 aa)
SPNS2Sphingolipid transporter 2. (510 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1583 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
HOMER3Sema domain-containing protein; Belongs to the semaphorin family. (763 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
IFITM5Uncharacterized protein. (131 aa)
NPPC-2C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (130 aa)
SULF2Extracellular sulfatase. (873 aa)
SH2B3SH2B adaptor protein 3. (539 aa)
P3H1Prolyl 3-hydroxylase 1; Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts (By similarity); Belongs to the leprecan family. (725 aa)
TMEM119Transmembrane protein 119. (245 aa)
GP9Glycoprotein IX platelet. (208 aa)
FREM1FRAS1 related extracellular matrix 1. (2184 aa)
CER1Cerberus; Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo; Belongs to the DAN family. (272 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
AKAP13Uncharacterized protein. (1341 aa)
LRRK1Leucine rich repeat kinase 1. (1998 aa)
FGF4Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1815 aa)
DDR1Uncharacterized protein. (873 aa)
ABI1Uncharacterized protein. (507 aa)
ATP6AP1Uncharacterized protein. (455 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
IFT80Intraflagellar transport 80. (790 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
SNX10PX domain-containing protein. (201 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
EPYCEpiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (316 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
EP300E1A binding protein p300. (2450 aa)
BMP6Bone morphogenetic protein 6. (434 aa)
PEX7WD_REPEATS_REGION domain-containing protein. (360 aa)
TRIM45Tripartite motif containing 45. (358 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
EVCUncharacterized protein. (984 aa)
WHSC1-2Uncharacterized protein. (592 aa)
RIPPLY2Ripply transcriptional repressor 2. (131 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
IFT172Intraflagellar transport 172. (1749 aa)
MMP13ZnMc domain-containing protein. (530 aa)
CHADUncharacterized protein. (361 aa)
LEPRUncharacterized protein. (1148 aa)
PHOSPHO2Phosphatase, orphan 2. (244 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
MYOCMyocilin. (467 aa)
BMPR1BBone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptiona (By similarity). Positively regulates chondrocyte differentiation. (502 aa)
SEMA4DSemaphorin-4D; Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). (855 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
ALPLAlkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. (519 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. (697 aa)
AMER1APC membrane recruitment protein 1. (1163 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
TMEM38BTransmembrane protein 38B. (287 aa)
OGNMimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (556 aa)
GLG1Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity). Binds fibroblast growth factor (FGF). May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS. (1194 aa)
ENSGALP00000044025Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (617 aa)
SH3PXD2BSH3 and PX domains 2B. (876 aa)
IMPAD1Inositol monophosphatase domain containing 1. (356 aa)
MEF2DMADS-box domain-containing protein. (570 aa)
RAB23Uncharacterized protein. (237 aa)
HOXA11Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa)
SP5Uncharacterized protein. (369 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
EXT2Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (717 aa)
OSTNUncharacterized protein. (148 aa)
FOXN3Forkhead box N3. (532 aa)
ZBTB32Uncharacterized protein. (665 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
CTC1Uncharacterized protein. (1282 aa)
BNC2Basonuclin 2. (1059 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (901 aa)
FLI1Uncharacterized protein. (432 aa)
TTC9Tetratricopeptide repeat domain 9. (208 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
SDC3Syndecan-3; Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage [...] (405 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (268 aa)
MIGA2Mitoguardin 2. (591 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SRFSerum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SULF1Sulfatase 1. (862 aa)
PTPRCUncharacterized protein. (1237 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
MAPK11Mitogen-activated protein kinase. (360 aa)
ANXA6Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity). (782 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
WISP1Uncharacterized protein. (359 aa)
DHRS3Uncharacterized protein. (302 aa)
RPL1360S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (211 aa)
MCPH1Uncharacterized protein. (589 aa)
ZNF385AZinc finger protein 385A. (319 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa)
NPPCC-type natriuretic peptide. (121 aa)
FAM20CLFam20C domain-containing protein. (139 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1580 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa)
SLC10A7Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (355 aa)
WHSC1Uncharacterized protein. (537 aa)
SLC38A10Solute carrier family 38 member 10. (1251 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (494 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1079 aa)
RANBP3LRAN binding protein 3 like. (534 aa)
ENSGALP00000068281ANK_REP_REGION domain-containing protein. (213 aa)
LRRC17p37NB protein. (437 aa)
LOC101750889LRRCT domain-containing protein. (714 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1175 aa)
NAB2NGFI-A binding protein 2. (672 aa)
PHEXUncharacterized protein. (747 aa)
TMEM107Uncharacterized protein. (159 aa)
WASF2WASP family member 2. (528 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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