22 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	LRIG2	Leucine rich repeats and immunoglobulin like domains 2. (1055 aa)
	SULF2	Extracellular sulfatase. (873 aa)
	SERPINE2	SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	EDN1	Endothelin 1. (194 aa)
	NTRK1	High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa)
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1206 aa)
	ISL1	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
	POU4F1	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
	RNF165	Ring finger protein 165. (350 aa)
	CHD9	Chromodomain helicase DNA binding protein 9. (2820 aa)
	ENSGALP00000048186	Uncharacterized protein. (528 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
	SULF1	Sulfatase 1. (862 aa)
	CHD7	Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
	SLITRK6	SLIT and NTRK like family member 6. (840 aa)
	ENSGALP00000069955	Uncharacterized protein. (496 aa)
	FBXO45	F-box protein 45. (107 aa)
	LOC107050371	Uncharacterized protein. (1015 aa)
	ENSGALP00000072609	Uncharacterized protein. (215 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSGALP00000020756	ENSGALP00000016244	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDNRA	EDN1	ENSGALP00000016244	ENSGALP00000020756	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000048186	LOC107050371	ENSGALP00000048186	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	ENSGALP00000048186	ENSGALP00000069955	ENSGALP00000048186	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSGALP00000069955	LOC107050371	ENSGALP00000069955	ENSGALP00000071652	Uncharacterized protein.	Uncharacterized protein.	0.900
ENSGALP00000072609	SULF1	ENSGALP00000072609	ENSGALP00000054958	Uncharacterized protein.	Sulfatase 1.	0.899
ISL1	NTRK1	ENSGALP00000043151	ENSGALP00000021606	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...]	0.603
ISL1	POU4F1	ENSGALP00000043151	ENSGALP00000046501	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]	0.868
LOC107050371	ENSGALP00000048186	ENSGALP00000071652	ENSGALP00000048186	Uncharacterized protein.	Uncharacterized protein.	0.899
LOC107050371	ENSGALP00000069955	ENSGALP00000071652	ENSGALP00000069955	Uncharacterized protein.	Uncharacterized protein.	0.900
LRIG1	LRIG2	ENSGALP00000035449	ENSGALP00000002658	Leucine rich repeats and immunoglobulin like domains 1.	Leucine rich repeats and immunoglobulin like domains 2.	0.495
LRIG2	LRIG1	ENSGALP00000002658	ENSGALP00000035449	Leucine rich repeats and immunoglobulin like domains 2.	Leucine rich repeats and immunoglobulin like domains 1.	0.495
LRIG2	RET	ENSGALP00000002658	ENSGALP00000060008	Leucine rich repeats and immunoglobulin like domains 2.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.401
NTRK1	ISL1	ENSGALP00000021606	ENSGALP00000043151	High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...]	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.603
NTRK1	POU4F1	ENSGALP00000021606	ENSGALP00000046501	High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...]	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]	0.712
POU4F1	ISL1	ENSGALP00000046501	ENSGALP00000043151	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.868
POU4F1	NTRK1	ENSGALP00000046501	ENSGALP00000021606	POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...]	High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...]	0.712
RET	LRIG2	ENSGALP00000060008	ENSGALP00000002658	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	Leucine rich repeats and immunoglobulin like domains 2.	0.401
SULF1	ENSGALP00000072609	ENSGALP00000054958	ENSGALP00000072609	Sulfatase 1.	Uncharacterized protein.	0.899