(20 nodes) Neuroepithelial cell differentiation network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	WNT11	Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
	LHX3	LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
	ABL1	Tyrosine-protein kinase. (1111 aa)
	B9D1	B9 domain containing 1. (196 aa)
	BCCIP	Protein BCCIP homolog; Belongs to the BCP1 family. (303 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
	DLX3	Homeobox domain-containing protein. (451 aa)
	FAM20CL	Fam20C domain-containing protein. (139 aa)
	TMEM231	Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (320 aa)
	LHX4	LIM homeobox 4. (533 aa)
	ABL2	Tyrosine-protein kinase. (1159 aa)
	CDH15	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	FAM20C	FAM20C golgi associated secretory pathway kinase. (556 aa)
	OTP	Orthopedia homeobox. (325 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	WNT11B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (386 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
	CDH2	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
	VAX1	Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSGALP00000006154	ENSGALP00000052767	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ABL1	CDH15	ENSGALP00000006154	ENSGALP00000047962	Tyrosine-protein kinase.	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins.	0.533
ABL1	CDH2	ENSGALP00000006154	ENSGALP00000024371	Tyrosine-protein kinase.	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	0.533
ABL2	ABL1	ENSGALP00000052767	ENSGALP00000006154	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
B9D1	TMEM231	ENSGALP00000008160	ENSGALP00000058774	B9 domain containing 1.	Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).	0.984
CDH15	ABL1	ENSGALP00000047962	ENSGALP00000006154	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins.	Tyrosine-protein kinase.	0.533
CDH15	CDH2	ENSGALP00000047962	ENSGALP00000024371	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	0.550
CDH2	ABL1	ENSGALP00000024371	ENSGALP00000006154	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	Tyrosine-protein kinase.	0.533
CDH2	CDH15	ENSGALP00000024371	ENSGALP00000047962	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins.	0.550
CDH2	FAM20C	ENSGALP00000024371	ENSGALP00000043726	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	FAM20C golgi associated secretory pathway kinase.	0.513
CDH2	FGF2	ENSGALP00000024371	ENSGALP00000031519	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family.	0.602
CDH2	FGF8	ENSGALP00000024371	ENSGALP00000032574	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.695
CDH2	WNT11	ENSGALP00000024371	ENSGALP00000001229	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters.	0.401
DLL1	FGF8	ENSGALP00000067155	ENSGALP00000032574	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.537
DLL1	JAG1	ENSGALP00000067155	ENSGALP00000014662	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.689
DLX3	FGF8	ENSGALP00000067082	ENSGALP00000032574	Homeobox domain-containing protein.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.564
FAM20C	CDH2	ENSGALP00000043726	ENSGALP00000024371	FAM20C golgi associated secretory pathway kinase.	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	0.513
FGF2	CDH2	ENSGALP00000031519	ENSGALP00000024371	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family.	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).	0.602
FGF2	FGF8	ENSGALP00000031519	ENSGALP00000032574	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.547
FGF2	JAG1	ENSGALP00000031519	ENSGALP00000014662	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.536