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| | ENSGALP00000073444 | Uncharacterized protein. (67 aa) |
| | LOC395100 | Cryptochrome-like protein. (529 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (569 aa) |
| | GUCA1A | Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. (199 aa) |
| | FOXK2 | Forkhead box K2. (653 aa) |
| | DM5L | Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa) |
| | C1QTNF12 | C1q and TNF related 12. (320 aa) |
| | SEC14L5 | SEC14 like lipid binding 5. (710 aa) |
| | DGKQ | Diacylglycerol kinase. (904 aa) |
| | H6PD | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (790 aa) |
| | MST1 | Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (704 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | ERLIN2 | ER lipid raft associated 2. (342 aa) |
| | ERLIN1 | PHB domain-containing protein. (347 aa) |
| | MTOR | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (804 aa) |
| | SOGA1 | Suppressor of glucose, autophagy associated 1. (1719 aa) |
| | BNIP2 | BCL2 interacting protein 2. (321 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (528 aa) |
| | PRMT3 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | FOXK1 | Forkhead box K1. (600 aa) |
| | PPTC7 | Protein phosphatase; Belongs to the PP2C family. (249 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (802 aa) |
| | TTC39B | Tetratricopeptide repeat domain 39B. (554 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (501 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | PGP | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. (312 aa) |
| | DUSP12 | Uncharacterized protein. (309 aa) |
| | APOA1 | Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (191 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | EGR1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa) |
| | SNAI1 | Snail like protein. (256 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | GPR50 | Melatonin receptor type 1C; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (346 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (728 aa) |
| | PDK4 | Protein-serine/threonine kinase. (414 aa) |
| | SLC7A11 | Solute carrier family 7 member 11 xCT. (501 aa) |
| | RD3 | Retinal degeneration 3, GUCY2D regulator. (350 aa) |
| | TTC39A | Tetratricopeptide repeat domain 39A. (576 aa) |
| | AK4 | Adenylate kinase 4; Belongs to the adenylate kinase family. (171 aa) |
| | NR1H4 | Farnesoid X receptor. (473 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | CRY1 | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] (621 aa) |
| | SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (309 aa) |
| | BMP6 | Bone morphogenetic protein 6. (434 aa) |
| | CGTL | Uncharacterized protein. (474 aa) |
| | FH | Uncharacterized protein. (507 aa) |
| | PDK1 | Protein-serine/threonine kinase; Belongs to the PDK/BCKDK protein kinase family. (408 aa) |
| | MTNR1A | Melatonin receptor type 1A; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (353 aa) |
| | PTPN2 | Uncharacterized protein. (597 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (560 aa) |
| | ZBTB20 | Zinc finger and BTB domain containing 20. (669 aa) |
| | BEND3 | BEN domain containing 3. (836 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (284 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (803 aa) |
| | ABCG1 | ATP binding cassette subfamily G member 1. (666 aa) |
| | PDK3 | Protein-serine/threonine kinase. (406 aa) |
| | EPHX2 | AB hydrolase-1 domain-containing protein. (596 aa) |
| | CLYBL | Citrate lyase beta like. (330 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (761 aa) |
| | HTR2A | 5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa) |
| | ADORA2B | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa) |
| | GUCA1C | Guanylate cyclase activator 1C. (209 aa) |
| | SIRT7 | Deacetylase sirtuin-type domain-containing protein. (399 aa) |
| | ARV1 | ARV1 homolog, fatty acid homeostasis modulator. (234 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) |
| | LEPR | Uncharacterized protein. (1148 aa) |
| | GCG | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa) |
| | LCMT1 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (411 aa) |
| | PRXL2C | Peroxiredoxin like 2C. (222 aa) |
| | GUCA1B | Guanylyl cyclase-activating protein 2; Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). (307 aa) |
| | APP | BPTI/Kunitz inhibitor domain-containing protein. (751 aa) |
| | PDXP | Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (300 aa) |
| | ENSGALP00000073548 | Uncharacterized protein. (77 aa) |
| | SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) |
| | ARPP19 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family. (112 aa) |
| | PDZD3 | PDZ domain containing 3. (531 aa) |
| | TIGAR | TIGAR. (280 aa) |
| | COX11 | Cytochrome c oxidase copper chaperone COX11. (277 aa) |
| | SREBF1 | BHLH domain-containing protein. (1116 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa) |
| | ETFBKMT | Uncharacterized protein. (263 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) |
| | SLC35B4 | Solute carrier family 35 member B4. (331 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa) |
| | NKX1-1 | NK1 homeobox 1. (369 aa) |
| | NR1H3 | Uncharacterized protein. (519 aa) |
| | ABCG4 | ATP binding cassette subfamily G member 4. (685 aa) |
| | OGT | O-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa) |
| | ZNF692 | Uncharacterized protein. (522 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (579 aa) |
| | MLXIPL | BHLH domain-containing protein. (895 aa) |
| | MID1IP1 | THRSP-like protein. (159 aa) |
| | PID1 | Phosphotyrosine interaction domain-containing 1. (217 aa) |
| | TYSND1 | Trypsin domain containing 1. (493 aa) |
| | GNMT | Methyltransf_25 domain-containing protein. (172 aa) |
| | LPGAT1 | PlsC domain-containing protein. (400 aa) |
| | RORC | RAR related orphan receptor C. (461 aa) |
| | ENSGALP00000049677 | GPS2_interact domain-containing protein. (220 aa) |
| | PMAIP1 | Uncharacterized protein. (54 aa) |
| | IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) |
| | FMO5 | Flavin-containing monooxygenase. (277 aa) |
| | ABCD2 | Uncharacterized protein. (730 aa) |
| | PRRC2C-2 | Flavin-containing monooxygenase. (126 aa) |
| | PPARA | Uncharacterized protein. (468 aa) |
| | FMO3 | Dimethylaniline monooxygenase [N-oxide-forming]. (530 aa) |
| | SESN2 | Uncharacterized protein. (474 aa) |
| | NCOR1 | Uncharacterized protein. (440 aa) |
| | ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase. (234 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa) |
| | PPARGC1A | RRM domain-containing protein. (795 aa) |
| | EIF6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa) |
| | FABP5 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (291 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (212 aa) |
| | LOC430443 | Uncharacterized protein. (197 aa) |
| | SNAI2 | Uncharacterized protein. (258 aa) |
| | SREBF2 | Sterol regulatory element binding transcription factor 2. (1112 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity); Belongs to the NOS family. (1136 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa) |
| | ENSGALP00000059185 | Uncharacterized protein. (1062 aa) |
| | PDK2 | Protein-serine/threonine kinase. (412 aa) |
| | LPCAT3 | Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (501 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (378 aa) |
| | TSPO2 | Translocator protein 2. (190 aa) |
| | CD74 | Invariant chain isoform p41. (286 aa) |
| | CD244 | Ig-like domain-containing protein. (383 aa) |
| | MIDN | Midnolin. (444 aa) |
| | PLEK | Uncharacterized protein. (353 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa) |
| | GIP | GLUCAGON domain-containing protein. (139 aa) |
| | REST | Uncharacterized protein. (339 aa) |
| | DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30. (174 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa) |
| | ENSGALP00000068191 | Uncharacterized protein. (1629 aa) |
| | ACMSD | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (396 aa) |
| | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. (662 aa) |
| | TSPO | Uncharacterized protein. (516 aa) |
| | ENSGALP00000069003 | Ig-like domain-containing protein. (306 aa) |
| | STARD4 | START domain-containing protein. (224 aa) |
| | PODN | Podocan. (632 aa) |
| | FAM3C | ILEI domain-containing protein. (227 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (678 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa) |
| | P2RY6 | P2Y purinoceptor 3; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (328 aa) |
| | FGF1 | Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa) |
| | SCAP | SREBF chaperone. (1316 aa) |
| | GUCA2B | Uncharacterized protein. (110 aa) |
| | DNM1L | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa) |
| | ADCYAP1R1 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (499 aa) |
| | LONP2 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (856 aa) |
| | LACC1 | Uncharacterized protein. (438 aa) |
| | IGFBP4 | IGFBP N-terminal domain-containing protein. (284 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa) |
| | SIRT4 | Sirtuin 4. (332 aa) |
| | RORA | Uncharacterized protein. (524 aa) |
| | ENSGALP00000072532 | Uncharacterized protein. (463 aa) |
| | DAB2 | DAB adaptor protein 2. (715 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (856 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (697 aa) |
| | NCS1 | Neuronal calcium sensor 1. (265 aa) |
| | PPARD | Uncharacterized protein. (545 aa) |
| | NCOR2 | Nuclear receptor corepressor 2. (2464 aa) |
