(45 nodes) Negative regulation of small molecule metabolic process network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	DDIT4	DNA damage inducible transcript 4. (212 aa)
	SNAI2	Uncharacterized protein. (258 aa)
	SIRT6	Deacetylase sirtuin-type domain-containing protein. (378 aa)
	TSPO2	Translocator protein 2. (190 aa)
	PLEK	Uncharacterized protein. (353 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1238 aa)
	REST	Uncharacterized protein. (339 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (396 aa)
	TSPO	Uncharacterized protein. (516 aa)
	FAM3C	ILEI domain-containing protein. (227 aa)
	SIRT4	Sirtuin 4. (332 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (697 aa)
	SNAI1	Snail like protein. (256 aa)
	GPR50	Melatonin receptor type 1C; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (346 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (350 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (191 aa)
	C1QTNF12	C1q and TNF related 12. (320 aa)
	EP300	E1A binding protein p300. (2450 aa)
	CRY1	Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] (621 aa)
	MTNR1A	Melatonin receptor type 1A; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity). (353 aa)
	PGP	Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. (312 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (761 aa)
	SLC27A4	Solute carrier family 27 member 4. (802 aa)
	PRMT3	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (528 aa)
	BNIP2	BCL2 interacting protein 2. (321 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1719 aa)
	ERLIN1	PHB domain-containing protein. (347 aa)
	ERLIN2	ER lipid raft associated 2. (342 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	MST1	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (704 aa)
	LOC395100	Cryptochrome-like protein. (529 aa)
	LEPR	Uncharacterized protein. (1148 aa)
	PDXP	Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (300 aa)
	SOX9	Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
	PDZD3	PDZ domain containing 3. (531 aa)
	TIGAR	TIGAR. (280 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
	ETFBKMT	Uncharacterized protein. (263 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	PID1	Phosphotyrosine interaction domain-containing 1. (217 aa)
	PPARA	Uncharacterized protein. (468 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL2	ENSGALP00000008899	ENSGALP00000043205	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.628
ADIPOQ	LEPR	ENSGALP00000008899	ENSGALP00000032296	C1q domain-containing protein.	Uncharacterized protein.	0.754
ADIPOQ	PPARA	ENSGALP00000008899	ENSGALP00000053048	C1q domain-containing protein.	Uncharacterized protein.	0.798
ADIPOQ	SIRT1	ENSGALP00000008899	ENSGALP00000004350	C1q domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.681
APPL2	ADIPOQ	ENSGALP00000043205	ENSGALP00000008899	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.628
BRCA1	EP300	ENSGALP00000004383	ENSGALP00000019537	Uncharacterized protein.	E1A binding protein p300.	0.799
BRCA1	SIRT1	ENSGALP00000004383	ENSGALP00000004350	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.465
BRCA1	SIRT6	ENSGALP00000004383	ENSGALP00000062638	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.463
CRY1	MTNR1A	ENSGALP00000020598	ENSGALP00000022058	Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...]	Melatonin receptor type 1A; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).	0.506
CRY1	SIRT1	ENSGALP00000020598	ENSGALP00000004350	Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...]	Deacetylase sirtuin-type domain-containing protein.	0.549
CRY1	TSPO	ENSGALP00000020598	ENSGALP00000068563	Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...]	Uncharacterized protein.	0.449
CRY1	TSPO2	ENSGALP00000020598	ENSGALP00000063223	Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...]	Translocator protein 2.	0.449
DDIT4	EP300	ENSGALP00000055521	ENSGALP00000019537	DNA damage inducible transcript 4.	E1A binding protein p300.	0.521
EP300	BRCA1	ENSGALP00000019537	ENSGALP00000004383	E1A binding protein p300.	Uncharacterized protein.	0.799
EP300	DDIT4	ENSGALP00000019537	ENSGALP00000055521	E1A binding protein p300.	DNA damage inducible transcript 4.	0.521
EP300	PPARA	ENSGALP00000019537	ENSGALP00000053048	E1A binding protein p300.	Uncharacterized protein.	0.605
EP300	SIRT1	ENSGALP00000019537	ENSGALP00000004350	E1A binding protein p300.	Deacetylase sirtuin-type domain-containing protein.	0.750
EP300	SOX9	ENSGALP00000019537	ENSGALP00000037718	E1A binding protein p300.	Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...]	0.476
ERLIN1	ERLIN2	ENSGALP00000005232	ENSGALP00000004879	PHB domain-containing protein.	ER lipid raft associated 2.	0.902
ERLIN2	ERLIN1	ENSGALP00000004879	ENSGALP00000005232	ER lipid raft associated 2.	PHB domain-containing protein.	0.902