STRINGSTRING
MLKL MLKL OPN1LW OPN1LW PNPT1 PNPT1 ASIC1 ASIC1 STEAP4 STEAP4 PXDN PXDN HSF4 HSF4 HSF2 HSF2 ENSGALP00000066894 ENSGALP00000066894 HSF1 HSF1 SIGMAR1 SIGMAR1 SLC1A2 SLC1A2 HSF3 HSF3 ENSGALP00000054847 ENSGALP00000054847 PXDNL PXDNL ALOX5AP ALOX5AP RHO RHO CLYBL CLYBL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLKLMixed lineage kinase domain like pseudokinase. (486 aa)
OPN1LWRed-sensitive opsin; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (362 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (896 aa)
ASIC1Acid-sensing ion channel 1; Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. (710 aa)
STEAP4STEAP4 metalloreductase. (472 aa)
PXDNPeroxidasin. (1611 aa)
HSF4HSF_DOMAIN domain-containing protein. (510 aa)
HSF2Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. (596 aa)
ENSGALP00000066894Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (303 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] (343 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity). (242 aa)
SLC1A2Amino acid transporter. (554 aa)
HSF3Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted; Belongs to the HSF family. (551 aa)
ENSGALP00000054847Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (180 aa)
PXDNLUncharacterized protein. (1406 aa)
ALOX5APUncharacterized protein. (161 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (351 aa)
CLYBLCitrate lyase beta like. (330 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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