STRINGSTRING
ZNF277 ZNF277 ANKZF1 ANKZF1 EDN1 EDN1 IMPACT IMPACT SYK SYK FABP1 FABP1 RPS3 RPS3 ANXA1 ANXA1 RIPK1 RIPK1 FXN FXN SMPD3 SMPD3 TNFAIP3 TNFAIP3 RELA RELA CYP1B1 CYP1B1 PARK7 PARK7 TRPA1 TRPA1 CYP1C1 CYP1C1 SIGMAR1 SIGMAR1 CAT CAT IL6 IL6 ENSGALP00000070665 ENSGALP00000070665 OSER1 OSER1 PDCD10 PDCD10 MAPK13 MAPK13 NFE2L2 NFE2L2 SIRT1 SIRT1 SETX SETX AIFM1 AIFM1 AQP1 AQP1 TRPM2 TRPM2 NET1 NET1 ECT2 ECT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF277C2H2-type domain-containing protein. (428 aa)
ANKZF1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (717 aa)
EDN1Endothelin 1. (194 aa)
IMPACTImpact RWD domain protein. (320 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
FABP1Fatty acid-binding protein, liver. (127 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
RIPK1Uncharacterized protein. (682 aa)
FXNFrataxin. (167 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (662 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
PARK7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
TRPA1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1126 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity). (242 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
ENSGALP00000070665Nuclear factor, erythroid 2. (326 aa)
OSER1Uncharacterized protein. (295 aa)
PDCD10Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Belongs to the PDCD10 family. (212 aa)
MAPK13Mitogen-activated protein kinase. (362 aa)
NFE2L2BZIP domain-containing protein. (593 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
SETXSenataxin. (2801 aa)
AIFM1Uncharacterized protein. (689 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
NET1Uncharacterized protein. (540 aa)
ECT2Epithelial cell transforming 2. (914 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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