(14 nodes) Lens fiber cell differentiation network (Gallus gallus)

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Predicted Interactions

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Your Input:
	TBC1D20	TBC1 domain family member 20. (394 aa)
	PROX1	Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
	FRS2	IRS-type PTB domain-containing protein. (508 aa)
	TDRD7	Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis. (1095 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	NF2	FERM domain-containing protein. (595 aa)
	FZR1	WD_REPEATS_REGION domain-containing protein. (493 aa)
	ATF4	ATF4. (354 aa)
	BFSP1	Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments. (657 aa)
	WNT7B	Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). (353 aa)
	SKIL	c-SKI_SMAD_bind domain-containing protein. (690 aa)
	EPHA2	EPH receptor A2. (1288 aa)
	SIX3	Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
	NF2L	FERM domain-containing protein. (648 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	BCL2	ENSGALP00000037099	ENSGALP00000020984	ATF4.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.548
BCL2	ATF4	ENSGALP00000020984	ENSGALP00000037099	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	ATF4.	0.548
BFSP1	EPHA2	ENSGALP00000038611	ENSGALP00000057639	Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments.	EPH receptor A2.	0.481
BFSP1	TDRD7	ENSGALP00000038611	ENSGALP00000020149	Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments.	Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.	0.672
EPHA2	BFSP1	ENSGALP00000057639	ENSGALP00000038611	EPH receptor A2.	Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments.	0.481
EPHA2	TDRD7	ENSGALP00000057639	ENSGALP00000020149	EPH receptor A2.	Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.	0.501
NF2	NF2L	ENSGALP00000032938	ENSGALP00000071709	FERM domain-containing protein.	FERM domain-containing protein.	0.901
NF2L	NF2	ENSGALP00000071709	ENSGALP00000032938	FERM domain-containing protein.	FERM domain-containing protein.	0.901
TDRD7	BFSP1	ENSGALP00000020149	ENSGALP00000038611	Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.	Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments.	0.672
TDRD7	EPHA2	ENSGALP00000020149	ENSGALP00000057639	Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis.	EPH receptor A2.	0.501