(10 nodes) interleukin-1-mediated signaling pathway network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EGR1	Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
	TNIP2	CCHC NOA-type domain-containing protein. (521 aa)
	IL1R1	Uncharacterized protein. (554 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1144 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	IKBKB	Protein kinase domain-containing protein. (753 aa)
	IL1RL2	Uncharacterized protein. (584 aa)
	RPS6KA5	Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcrip [...] (803 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IRAK2	Protein kinase domain-containing protein. (725 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR1	IL1B	ENSGALP00000012417	ENSGALP00000050171	Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...]	Interleukin-1; Belongs to the IL-1 family.	0.416
IKBKB	IL1B	ENSGALP00000051668	ENSGALP00000050171	Protein kinase domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.543
IKBKB	TRAF6	ENSGALP00000051668	ENSGALP00000068399	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.875
IL1B	EGR1	ENSGALP00000050171	ENSGALP00000012417	Interleukin-1; Belongs to the IL-1 family.	Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...]	0.416
IL1B	IKBKB	ENSGALP00000050171	ENSGALP00000051668	Interleukin-1; Belongs to the IL-1 family.	Protein kinase domain-containing protein.	0.543
IL1B	IL1R1	ENSGALP00000050171	ENSGALP00000045214	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.993
IL1B	IL1RL2	ENSGALP00000050171	ENSGALP00000054717	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.915
IL1B	IRAK2	ENSGALP00000050171	ENSGALP00000072173	Interleukin-1; Belongs to the IL-1 family.	Protein kinase domain-containing protein.	0.613
IL1B	TRAF6	ENSGALP00000050171	ENSGALP00000068399	Interleukin-1; Belongs to the IL-1 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.875
IL1R1	IL1B	ENSGALP00000045214	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.993
IL1R1	IL1RL2	ENSGALP00000045214	ENSGALP00000054717	Uncharacterized protein.	Uncharacterized protein.	0.554
IL1R1	IRAK2	ENSGALP00000045214	ENSGALP00000072173	Uncharacterized protein.	Protein kinase domain-containing protein.	0.755
IL1R1	TRAF6	ENSGALP00000045214	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.787
IL1RL2	IL1B	ENSGALP00000054717	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.915
IL1RL2	IL1R1	ENSGALP00000054717	ENSGALP00000045214	Uncharacterized protein.	Uncharacterized protein.	0.554
IL1RL2	IRAK2	ENSGALP00000054717	ENSGALP00000072173	Uncharacterized protein.	Protein kinase domain-containing protein.	0.594
IL1RL2	TNIP2	ENSGALP00000054717	ENSGALP00000044555	Uncharacterized protein.	CCHC NOA-type domain-containing protein.	0.605
IL1RL2	TRAF6	ENSGALP00000054717	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.459
IRAK2	IL1B	ENSGALP00000072173	ENSGALP00000050171	Protein kinase domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.613
IRAK2	IL1R1	ENSGALP00000072173	ENSGALP00000045214	Protein kinase domain-containing protein.	Uncharacterized protein.	0.755